Yazar "Erbas, Oytun" için listeleme
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The effect of Madopar on absence-like seizures in WAG/Rij rats
Al-Kaleel, Ali; Erbas, Oytun; Aygun, Hatice (Nencki Inst Experimental Biology, 2022)The aim of this study was to investigate the effect of Madopar on the absence seizures and the anxiety-like behavior (assessed using the open field test) in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. Twenty-eight male ... -
Effect of platelet-rich plasma on reconstruction with nerve autografts
Teymur, Hakan; Tiftikcioglu, Yigit Ozer; Cavusoglu, Turker; Tiftikcioglu, Bedile Irem; Erbas, Oytun; Yigitturk, Gurkan; Uyanikgil, Yigit (ELSEVIER TAIWAN, 2017)Despite advances in understanding of peripheral nerve injuries and regeneration and advances in surgical techniques, successful outcomes cannot be guaranteed after reconstructive surgery. Platelet-rich plasma (PRP) has ... -
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions
Erdogan, Arife; Erdogan, Mumin Alper; Gurgul, Serkan; Erbas, Oytun (Springer/Plenum Publishers, 2023)Epilepsy is a disease which affects between 1 and 2% of the population, and a large proportion of these people do not react to currently available anticonvulsant medications, indicating the need for further research into ... -
The effects of diltiazem and metoprolol in QTc prolongation due to amitriptyline intoxication
Basol, Nursah; Erbas, Oytun (SAGE PUBLICATIONS LTD, 2016)Background and objective: Amitriptyline, a frequently used tricyclic antidepressant agent, has powerful cardiotoxic effects especially in high doses. Serum and urine levels of amitriptyline dosages are not correlated with ... -
The Effects of Lipid Emulsion, Magnesium Sulphate and Metoprolol in Amitriptyline-Induced Cardiovascular Toxicity in Rats
Bora, Saylav; Erdogan, Mumin Alper; Yigitturk, Gurkan; Erbas, Oytun; Parlak, Ismet (HUMANA PRESS INC, 2018)The aim of this study was to evaluate the effects of metoprolol, lipid emulsion and MgSO4 which can be recommended for prevention of long QT that is one of the lethal consequences of amitriptyline intoxication. Thirty ... -
Effects of Methylene Blue on Ovarian Torsion - Detorsion Injury in a Rat Model
Ilgen, Orkun; Hortu, Ismet; Ozceltik, Gokay; Yigitturk, Gurkan; Erbas, Oytun; Karadadas, Nedim (Elsevier Science Inc, 2020)Study Objectives -
Effects of prenatal testosterone exposure on the development of autism-like behaviours in offspring of Wistar rats
Erdogan, Mumin Alper; Bozkurt, Mehmet Fatih; Erbas, Oytun (Wiley, 2023)BackgroundA neurodevelopmental disease, autism spectrum disorder (ASD) occurs in males three times more commonly than girls. Higher prenatal testosterone exposure may result in autistic-like behaviour in boys, according ... -
Effects of the Calcium Channel Blocker Otilonium Bromide on Seizure Activity in Rats With Pentylenetetrazole-Induced Convulsions
Erdogan, Arife; Erdogan, Mumin Alper; Atasoy, Ozum; Erbas, Oytun (Springer/Plenum Publishers, 2021)Millions of people suffer from drug-resistant epilepsy. New therapeutic approaches for removing this life-affecting disease are required. The activation of T-type calcium channels (TTCC) is one of the epileptogenesis ... -
Effects of the Prenatal Administration of Tetanus Toxoid on the Sociability and Explorative Behaviors of Rat Offspring: A Preliminary Study
Sunnetci, Eda; Durankus, Ferit; Albayrak, Yakup; Erdogan, Mumin Alper; Atasoy, Ozum; Erbas, Oytun (Korean Coll Neuropsychopharmacology, 2021)Objective: Autism spectrum disorder (ASD) is a severely disabling psychiatric disease characterized by impairments in communication and social skills. Although efforts have been made to explore the etiology of ASD, its ... -
Effects of vitrification solution supplemented with platelet-rich plasma in rat ovarian tissue cryopreservation
Gokhan, Aylin; Cavusoglu, Tuerker; Kilic, Kubilay Dogan; Sirin, Cansin; Tomruk, Canberk; Yigitturk, Guerkan; Erbas, Oytun (Tubitak Scientific & Technological Research Council Turkey, 2023)Background/aim: The subject of this study was to investigate the utility of platelet-rich plasma (PRP) in the cryopreservation process to reduce cryodamage and increase tissue viability.Materials and methods: Twenty-one ... -
The efficacy of Aesculus hippocastanum seeds on diabetic nephropathy in a streptozotocin-induced diabetic rat model
Elmas, Onur; Erbas, Oytun; Yigitturk, Gurkan (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2016)Cytokines, such as transforming growth factor (TGF)-beta 1, and increased oxidative stress are considered to be responsible for the development of diabetic nephropathy. We hypothesized that Aesculus hippocastanum (AH) seeds ... -
Erythropoietin shows gender dependent positive effects on social deficits, learning/memory impairments, neuronal loss and neuroinflammation in the lipopolysaccharide induced rat model of autism
Solmaz, Volkan; Erdogan, Mumin Alper; Alnak, Alper; Meral, Ayfer; Erbas, Oytun (Churchill Livingstone, 2020)We aimed to evaluate the effects of EPO in the lipopolysaccharide (LPS) induced rat model of autism in terms of social deficits, learning and memory impairments, as well as their neurochemical correlates. Sixteen female ... -
Evaluation of long-term effects of artificial sweeteners on rat brain: a biochemical, behavioral, and histological study
Erbas, Oytun; Erdogan, Mumin Alper; Khalilnezhad, Asghar; Solmaz, Volkan; Gurkan, Fulya Tuzcu; Yigitturk, Gurkan; Taskiran, Dilek (WILEY, 2018)The aim of the present study was to compare the effects of artificial sweeteners (aspartame, saccharin, and sucralose) on rat brain. Twenty-four adult male Sprague-Dawley rats were included in the study. The control group ... -
Exenatide preserves trabecular bone microarchitecture in experimental ovariectomized rat model
Eminov, Elmin; Hortu, Ismet; Akman, Levent; Erbas, Oytun; Yavasoglu, Altug; Cirpan, Teksin (SPRINGER HEIDELBERG, 2018)Purpose The aim of this study is to investigate effects of exenatide (Glucagon-Like Peptide Agonist) replacement on bone mineral density (BMD) and microarchitecture in a surgical menopause-induced osteoporosis model in ... -
Exenatide reduces TNF-alpha expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats
Solmaz, Volkan; Cinar, Bilge Piri; Yigitturk, Gurkan; Cavusoglu, Turker; Taskiran, Dilek; Erbas, Oytun (ELSEVIER SCIENCE BV, 2015)Recent studies suggest a possible link between type 2 diabetes and Alzheimer's disease (AD). Glucoganlike peptide 1 (GLP-1) facilitates insulin release from pancreas under hyperglycemic conditions. In addition to its ... -
Exenatide, a GLP-1 analog, has healing effects on LPS-induced autism model: Inflammation, oxidative stress, gliosis, cerebral GABA, and serotonin interactions
Solmaz, Volkan; Tekatas, Aslan; Erdogan, Mumin Alper; Erbas, Oytun (Wiley, 2020)Previous studies have established anti-inflammatory, antioxidant, and neuroprotective effects of Exenatide in the central nervous system. Since these mechanisms are thought to have important roles in the pathophysiology ... -
Exogenously administered adenosine attenuates renal damage in streptozotocin-induced diabetic rats
Taskiran, Emin; Erbas, Oytun; Yigitturk, Gurkan; Meral, Ayfer; Akar, Harun; Taskiran, Dilek (TAYLOR & FRANCIS LTD, 2016)Background: Diabetic nephropathy (DNP) is one of the most serious complications of diabetes mellitus (DM). In the present study, we investigated the potential of adenosine as a therapeutic candidate for preventing DNP.Methods: ... -
An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment
Taskin, Banu; Erdogan, Mumin Alper; Yigitturk, Gurkan; Alper, Sibel; Erbas, Oytun (Hindawi Ltd, 2021)Purpose. The aim of the study is to examine the possible therapeutic effects of a known cardiac glycoside, digoxin, on a rat model of MTX-induced hepatotoxicity. Methods. The study was conducted on twenty-four male rats. ... -
Exposure to hypertonic solutions during pregnancy induces autism-like behaviors via the NFAT-5 pathway in offspring in a rat model
Senkal, Evrim; Bagcioglu, Erman; Eryigit, Umut; Erbas, Oytun; Solmaz, Volkan (Pergamon-Elsevier Science Ltd, 2021)Objectives: to investigate the effects of hyperosmolar state (HS) on immune response and inflammation via the NFAT5 pathway and examine whether immune-mediated conditions trigger autism-like behavior in offspring. Methods: ... -
Granulocyte colony-stimulating factor has a sex-dependent positive effect in the maternal immune activation-induced autism model
Durankus, Ferit; Albayrak, Yakup; Erdogan, Firat; Albayrak, Neslihan; Erdogan, Mumin Alper; Erbas, Oytun (Wiley, 2022)Objective The medical intervention for autism spectrum disorder (ASD) is restricted to ameliorating comorbid situations. Granulocyte colony-stimulating factor (G-CSF) is a growth factor that enhances the proliferation, ...