Yazar "Erdogan, Mumin Alper" için listeleme
-
An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment
Taskin, Banu; Erdogan, Mumin Alper; Yigitturk, Gurkan; Alper, Sibel; Erbas, Oytun (Hindawi Ltd, 2021)Purpose. The aim of the study is to examine the possible therapeutic effects of a known cardiac glycoside, digoxin, on a rat model of MTX-induced hepatotoxicity. Methods. The study was conducted on twenty-four male rats. ... -
Granulocyte colony-stimulating factor has a sex-dependent positive effect in the maternal immune activation-induced autism model
Durankus, Ferit; Albayrak, Yakup; Erdogan, Firat; Albayrak, Neslihan; Erdogan, Mumin Alper; Erbas, Oytun (Wiley, 2022)Objective The medical intervention for autism spectrum disorder (ASD) is restricted to ameliorating comorbid situations. Granulocyte colony-stimulating factor (G-CSF) is a growth factor that enhances the proliferation, ... -
The Healing Effect of Digoxin on Peripheral Nerve Damage and Its Relation to IL-17/IL-10
Gurkan, Gokhan; Erdogan, Mumin Alper; Karahan, Gokhan; Kaya, Huseyin; Yigitturk, Gurkan; Kizmazoglu, Ceren; Erbas, Oytun (Turkish Neurosurgical Soc, 2023)AIM: To demonstrate the curative effect of digoxin on peripheral nerve damage with its anti-inflammatory role on interleukin (IL)-17. MATERIAL and METHODS: The study was conducted with 30 male Sprague Dawley albino mature ... -
Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy
Erdogan, Mumin Alper; Yusuf, Dimas; Christy, Joanna; Solmaz, Volkan; Erdogan, Arife; Taskiran, Emin; Erbas, Oytun (BIOMED CENTRAL LTD, 2018)Background: Worldwide, over 10 million individuals suffer from drug-resistant epilepsy. New therapeutic strategies are needed to address this debilitating disease. Inhibition of sodium-glucose linked transporters (SGLTs), ... -
Immunosuppressant Tacrolimus Treatment Delays Acute Seizure Occurrence, Reduces Elevated Oxidative Stress, and Reverses PGF2? Burst in the Brain of PTZ-Treated Rats
Pazarlar, Burcu Azak; Egilmez, Cansu Bilister; Erdogan, Mumin Alper; Erbas, Oytun (Springer/Plenum Publishers, 2023)It is still an urgent need to find alternative and effective therapies to combat epileptic seizures. Tacrolimus as a potent immunosuppressant and calcineurin inhibitor is emerging as promising drug to suppress seizures. ... -
Levodropropizine suppresses seizure activity in rats with pentylenetetrazol-induced epilepsy
Erdogan, Mumin Alper; Yusuf, Dimas; Erdogan, Arife; Erbas, Oytun (ELSEVIER SCIENCE BV, 2019)Background: Millions of individuals worldwide suffer from epilepsy, and up to 25% of patients have seizures that are resistant to currently available antiepileptic drugs. Hence, there continues to be a need for more seizure ... -
N-acetyl cysteine: A new look at its effect on PTZ-induced convulsions
Egilmez, Cansu Bilister; Pazarlar, Burcu Azak; Erdogan, Mumin Alper; Erbas, Oytun (Elsevier, 2023)Introduction/Aim: Epilepsy is widely investigated as a common neurological disease requiring pharmacologically effective agents. N-acetyl cysteine (NAC), has become a remarkable molecule with its role in both antioxidant ... -
Neurobehavioral effects of long-term maternal fructose intake in rat offspring
Erbas, Oytun; Erdogan, Mumin Alper; Khalilnezhad, Asghar; Gurkan, Fulya Tuzcu; Yigitturk, Gurkan; Meral, Ayfer; Taskiran, Dilek (PERGAMON-ELSEVIER SCIENCE LTD, 2018)Background: Previous studies have indicated an association between maternal metabolic conditions and general developmental disturbances of the offspring. Objective: We aimed to investigate the influence of long-term maternal ... -
Neuroprotective effect of dexpanthenol on rotenone-induced Parkinson's disease model in rats
Egilmez, Cansu Bilister; Pazarlar, Burcu Azak; Erdogan, Mumin Alper; Erbas, Oytun (Elsevier Ireland Ltd, 2024)Parkinson's disease (PD) is the second most common and progressive neurodegenerative disease. This experimental study was designed to investigate the neuroprotective effects of dexpanthenol on antioxidant and antiinflammatory ... -
Neuroprotective effects of dexpanthenol on streptozotocin-induced neuronal damage in rats
Erdogan, Mumin Alper; Yigitturk, Gurkan; Erbas, Oytun; Taskiran, Dilek (Taylor & Francis Ltd, 2021)Aim Although the most common age-related neurodegenerative disease defined by memory loss is Alzheimer's disease (AD), only symptomatic therapies are present. A complex pathway for the AD pathogenesis that includes an ... -
The potential effects of anticonvulsant drugs on neuropeptides and neurotrophins in pentylenetetrazol kindled seizures in the rat
Tekgul, Hasan; Simsek, Erdem; Erdogan, Mumin Alper; Yigitturk, Gurkan; Erbas, Oytun; Taskiran, Dilek (Taylor & Francis Ltd, 2020)Purpose: Neuropeptides and neurotrophic factors are thought to be involved in epileptogenesis. This study aims to investigate the potential effects of anticonvulsant drugs on neuropeptides (galanin and neuropeptide Y) and ... -
Prenatal Exposure to COVID-19 mRNA Vaccine BNT162b2 Induces Autism-Like Behaviors in Male Neonatal Rats: Insights into WNT and BDNF Signaling Perturbations
Erdogan, Mumin Alper; Gurbuz, Orkun; Bozkurt, Mehmet Fatih; Erbas, Oytun (Springer/Plenum Publishers, 2024)The COVID-19 pandemic catalyzed the swift development and distribution of mRNA vaccines, including BNT162b2, to address the disease. Concerns have arisen about the potential neurodevelopmental implications of these vaccines, ... -
Prenatal SARS-CoV-2 Spike Protein Exposure Induces Autism-Like Neurobehavioral Changes in Male Neonatal Rats
Erdogan, Mumin Alper; Turk, Miray; Doganay, Gizem Dinler; Sever, Ibrahim Halil; Ozkul, Bahattin; Sogut, Ibrahim; Eroglu, Ebru (Springer, 2023)Recent research on placental, embryo, and brain organoids suggests that the COVID-19 virus may potentially affect embryonic organs, including the brain. Given the established link between SARS-CoV-2 spike protein and ... -
Protective effect of dapagliflozin on colistin-induced renal toxicity
Bora, Ejder Saylav; Erdogan, Mumin Alper; Meral, Ayfer; Karakaya, Zeynep; Erbas, Oytun (Mre Press, 2021)Objectives: Multiple-drug resistance to Gram-negative bacteria has increased significantly in recent years. Colistin is increasingly used as a last line of defense against these bacteria. However, colistin has been associated ... -
Protective Effect of Polyethylene Glycol (PEG) 3350 on a Cisplatin-Induced Rat Model of Neuropathy
Gonullu, Edip; Dagistan, Gozde; Erdogan, Mumin Alper; Erbas, Oytun (Asian Network Scientific Information-Ansinet, 2022)Background and Objective: Peripheral neuropathy is the most important side effect, leading to a decrease in the dose of cisplatin or its complete cessation in the early period. For this purpose, the study aimed to investigate ... -
The Protective Effects of Carvedilol on Diabetic Nephropathy in A Streptozotocin-Induced Diabetic Rat Model
Erdogan, Mumin Alper; Yigitturk, Gurkan; Erbas, Oytun (Wiley, 2019)[No abstract available] -
Protective Effects of Ibudilast Against Cisplatin-Induced Hepatotoxicity and Nephrotoxicity Mediated by Prostacyclin Enhancement
Ozkul, Ozlem; Ozkul, Bahattin; Erdogan, Mumin Alper; Erbas, Oytun (Asian Network Scientific Information-Ansinet, 2023)Background and Objective: Cisplatin, a prevalent chemotherapy drug, presents hepatotoxic and nephrotoxic side effects, this study explores ibudilast's potential protective effects against such damage via prostacyclin ... -
The reducing effect of agomelatine on pentylenetetrazol-induced convulsions
Demirel, Esra Aciman; Erdogan, Mumin Alper; Cinar, Bilge Piri; Erbas, Oytun (Akademiai Kiado Zrt, 2019)Introduction: Agomelatine is a potent MT1 and MT2 melatonin receptor agonist and a 5-HT2C serotonin receptor antagonist. the purpose of this study was to show the convulsion-reducing effect of agomelatine, in both clinical ... -
Research Article Nasal Oxytocin's Anticonvulsant Effects on Pentylenetetrazolinduced Convulsions in Rats
Bora, Ejder Saylav; Erdogan, Mumin Alper; Karaali, Rezan; Cakir, Adem; Erbas, Oytun (Asian Network Scientific Information-Ansinet, 2023)Background and Objective: Neurodegenerative proteins and pro-inflammatory mechanisms may cause epilepsy through excitatory-inhibitory imbalance. Drug resistance is common, therefore this disease requires affordable, ...
