Yazar "Erbas, Oytun" için listeleme
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Granulocyte colony-stimulating factor provides protection against cardiovascular autonomic neuropathy in streptozotocin-induced diabetes in rats
Erbas, Oytun; Solmaz, Volkan; Taskiran, Dilek (ELSEVIER IRELAND LTD, 2015)Aims: Cardiovascular autonomic neuropathy (CAN) is a relatively common and detrimental complication of diabetes mellitus (DM). Dysregulation of neuropeptides, such as calcitonin gene-related peptide (CGRP) and vasoactive ... -
The Healing Effect of Digoxin on Peripheral Nerve Damage and Its Relation to IL-17/IL-10
Gurkan, Gokhan; Erdogan, Mumin Alper; Karahan, Gokhan; Kaya, Huseyin; Yigitturk, Gurkan; Kizmazoglu, Ceren; Erbas, Oytun (Turkish Neurosurgical Soc, 2023)AIM: To demonstrate the curative effect of digoxin on peripheral nerve damage with its anti-inflammatory role on interleukin (IL)-17. MATERIAL and METHODS: The study was conducted with 30 male Sprague Dawley albino mature ... -
Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy
Erdogan, Mumin Alper; Yusuf, Dimas; Christy, Joanna; Solmaz, Volkan; Erdogan, Arife; Taskiran, Emin; Erbas, Oytun (BIOMED CENTRAL LTD, 2018)Background: Worldwide, over 10 million individuals suffer from drug-resistant epilepsy. New therapeutic strategies are needed to address this debilitating disease. Inhibition of sodium-glucose linked transporters (SGLTs), ... -
Histone deacetylase inhibitor givinostat has ameliorative effect in the colitis model
Dibekoglu, Cengiz; Erbas, Oytun (Acta Cirurgica Brasileira, 2022)Purpose: To investigate the effect of givinostat treatment in acetic acid-induced ulcerative colitis model in rats. Methods: Thirty male Wistar albino rats were used. Rats were randomly divided into three equal groups, and ... -
Immunosuppressant Tacrolimus Treatment Delays Acute Seizure Occurrence, Reduces Elevated Oxidative Stress, and Reverses PGF2? Burst in the Brain of PTZ-Treated Rats
Pazarlar, Burcu Azak; Egilmez, Cansu Bilister; Erdogan, Mumin Alper; Erbas, Oytun (Springer/Plenum Publishers, 2023)It is still an urgent need to find alternative and effective therapies to combat epileptic seizures. Tacrolimus as a potent immunosuppressant and calcineurin inhibitor is emerging as promising drug to suppress seizures. ... -
Inhibitor effect of paricalcitol in rat model of pentylenetetrazol-induced seizures
Uyanikgil, Yigit; Solmaz, Volkan; Cavusoglu, Tuerker; Cinar, Bilge Piri; Cetin, Emel Oeykue; Sur, Halil YAnlmaz; Erbas, Oytun (SPRINGER, 2016)Vitamin D has various systemic effects on bone metabolism, modulation of the immune system, stabilization of the cell membrane, oxidative stress, inflammation, apoptosis, and various other hormones. Differing from active ... -
The investigation of therapeutic potential of oxytocin and liraglutide on vincristine-induced neuropathy in rats
Erdogan, Mumin A.; Taskiran, Emin; Yigitturk, Gurkan; Erbas, Oytun; Taskiran, Dilek (Wiley, 2020)The aim of this study was to assess the therapeutic potential of oxytocin and liraglutide (LIR), a GLP-1 analogue, in a rat model of vincristine-induced neuropathy. Rats were injected with vincristine (VCR) at a dose of 4 ... -
Levodropropizine suppresses seizure activity in rats with pentylenetetrazol-induced epilepsy
Erdogan, Mumin Alper; Yusuf, Dimas; Erdogan, Arife; Erbas, Oytun (ELSEVIER SCIENCE BV, 2019)Background: Millions of individuals worldwide suffer from epilepsy, and up to 25% of patients have seizures that are resistant to currently available antiepileptic drugs. Hence, there continues to be a need for more seizure ... -
Losartan ameliorates ovarian ischaemia/reperfusion injury in rats: an experimental study
Hortu, Ismet; Ilgen, Orkun; Sahin, Cagdas; Akdemir, Ali; Yigitturk, Gurkan; Erbas, Oytun (Taylor & Francis Inc, 2020)This study aimed to investigate the protective and antioxidant role of losartan in ovarian ischaemia and ischaemia/reperfusion injury in an experimental ovarian torsion model. Thirty adult female rats were used. Rats were ... -
Medroxyprogesterone acetate improves propionic acid-induced autism rat model and magnetic resonance spectroscopic correlation
Bozkurt, Mehmet Fatih; Bhayal, Muhammad Nasir; Severe, Ibrahim Halil; Ozku, Bahattin; Erbas, Oytun (Bangladesh Pharmacological Soc, 2022)The protective effect of medroxyprogesterone acetate on propionic acid induced autism in rats was evaluated. For this purpose, 30 rats were divided into three groups. The significant difference in the levels of IL-17 ... -
Modafinil Improves Autism-like Behavior in Rats by Reducing Neuroinflammation
Bagcioglu, Erman; Solmaz, Volkan; Erbas, Oytun; Ozkul, Bahattin; Cakar, Burak; Uyanikgil, Yigit; Sogut, Ibrahim (Springer, 2023)To evaluate the ameliorating effect of Modafinil on neuroinflammation, behavioral, and histopathological alterations in rats induced by propionic acid (PPA). Thirty male Wistar rats were used in the study, divided into 3 ... -
N-acetyl cysteine: A new look at its effect on PTZ-induced convulsions
Egilmez, Cansu Bilister; Pazarlar, Burcu Azak; Erdogan, Mumin Alper; Erbas, Oytun (Elsevier, 2023)Introduction/Aim: Epilepsy is widely investigated as a common neurological disease requiring pharmacologically effective agents. N-acetyl cysteine (NAC), has become a remarkable molecule with its role in both antioxidant ... -
NEPHROPROTECTIVE EFFECT OF ADENOSINE IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Taskiran, Emin; Erbas, Oytun; Yigitturk, Gurkan; Taskiran, Dilek; Akar, Harun (OXFORD UNIV PRESS, 2016)… -
The neuro-restorative effect of adipose-derived mesenchymal stem cell transplantation on a mouse model of diabetic neuropathy
Yigitturk, Gurkan; Erbas, Oytun; Karabay Yavasoglu, Nefise Ulku; Acikgoz, Eda; Buhur, Aylin; Gokhan, Aylin; Gurel, Cevik (Taylor & Francis Ltd, 2021)Diabetic neuropathy (DN) is the most common degenerative complication associated with Diabetes Mellitus. Despite widespread awareness about DN, the only effective treatments are blood glucose control and pain management. ... -
Neurobehavioral effects of long-term maternal fructose intake in rat offspring
Erbas, Oytun; Erdogan, Mumin Alper; Khalilnezhad, Asghar; Gurkan, Fulya Tuzcu; Yigitturk, Gurkan; Meral, Ayfer; Taskiran, Dilek (PERGAMON-ELSEVIER SCIENCE LTD, 2018)Background: Previous studies have indicated an association between maternal metabolic conditions and general developmental disturbances of the offspring. Objective: We aimed to investigate the influence of long-term maternal ... -
Neuroprotective effect of dexpanthenol on rotenone-induced Parkinson's disease model in rats
Egilmez, Cansu Bilister; Pazarlar, Burcu Azak; Erdogan, Mumin Alper; Erbas, Oytun (Elsevier Ireland Ltd, 2024)Parkinson's disease (PD) is the second most common and progressive neurodegenerative disease. This experimental study was designed to investigate the neuroprotective effects of dexpanthenol on antioxidant and antiinflammatory ... -
Neuroprotective effects of chronic administration of levetiracetam in a rat model of diabetic neuropathy
Erbas, Oytun; Oltulu, Fatih; Yilmaz, Mustafa; Yavasoglu, Altug; Taskiran, Dilek (ELSEVIER IRELAND LTD, 2016)Objective: Diabetic neuropathy (DNP) is a frequent and serious complication of diabetes mellitus (DM) that leads to progressive and length-dependent loss of peripheral nerve axons. The purpose of the present study is to ... -
Neuroprotective effects of dexpanthenol on streptozotocin-induced neuronal damage in rats
Erdogan, Mumin Alper; Yigitturk, Gurkan; Erbas, Oytun; Taskiran, Dilek (Taylor & Francis Ltd, 2021)Aim Although the most common age-related neurodegenerative disease defined by memory loss is Alzheimer's disease (AD), only symptomatic therapies are present. A complex pathway for the AD pathogenesis that includes an ...