Yazar "Bora, Ejder Saylav" için listeleme
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Antifibrotic preventive effect of polyethylene glycol (PEG) 3350 in methotrexate-induced hepatoxicity model
Acar, Huseyin; Sorgun, Omay; Yurtseve, Guner; Bora, Ejder Saylav; Erbas, Oytun (Acta Cirurgica Brasileira, 2022)Purpose: Liver damage caused by drugs and other chemicals accounts for about 5% of all cases. Methotrexate (MTX), a folic acid analogue, is a first-line synthetic antimetabolite agent routinely used in the treatment of ... -
Autophagy and anti-inflammation ameliorate diabetic neuropathy with Rilmenidine
Yalcin, Mehmet Burak; Bora, Ejder Saylav; Cakir, Adem; Akbulut, Sabiye; Erbas, Oytun (Acta Cirurgica Brasileira, 2023)Purpose: To evaluate the neuroprotective effects of Rilmenidine on diabetic peripheral neuropathy (DPN) in a rat model of diabetes induced by streptozotocin (STZ). Methods: STZ (60 mg/kg) was administered to adult ... -
Caffeine mitigates tamoxifen-induced fatty liver in Wistar rats
Sezgin, Yasin; Bora, Ejder Saylav; Arda, Duygu Burcu; Uyanikgil, Yigit; Erbas, Oytun (Acta Cirurgica Brasileira, 2024)Purpose: Tamoxifen, a widely used drug for breast cancer treatment, is associated with adverse effects on the liver, including the development of fatty liver. This study aimed to investigate the potential protective effect ... -
Demonstration of the Protective Effect of Vinpocetine in Diabetic Cardiomyopathy
Erciyes, Demet; Bora, Ejder Saylav; Tekindal, Mustafa Agah; Erbas, Oytun (Mdpi, 2024)Background: Diabetic cardiomyopathy (DCM) poses a significant risk for heart failure in individuals with diabetes, yet its underlying mechanisms remain incompletely understood. Elevated blood sugar levels initiate harmful ... -
The Effect of Adipose-Derived Mesenchymal Stem Cells on Peripheral Nerve Damage in a Rodent Model
Yalcin, Mehmet Burak; Bora, Ejder Saylav; Erdogan, Muemin Alper; Cakir, Adem; Erbas, Oytun (Mdpi, 2023)Peripheral nerve damage is a significant clinical problem with limited therapeutic options. Adipose-derived mesenchymal stem cells (ADSCs) have emerged as a promising therapeutic approach due to their regenerative potential. ... -
Effect of celecoxib on intra-abdominal sepsis-induced lung injury in rats
Dibekoğlu, Cengiz; Bora, Ejder Saylav; Eroğlu, Ebru; Yurtsever, Guner; Uyanikgil, Yiğit; Erbaş, Oytun (2023)Objectives: This experimental study investigated the preventive effects of Celecoxib, a selective COX-2 inhibitor, on lung injury induced by intra-abdominal sepsis in rats. The study assessed Celecoxib's potential to ... -
Exploring the Protective Effects of Astragaloside IV against Cisplatin-Induced Kidney Injury in Rats
Arda, Duygu Burcu; Bora, Ejder Saylav; Yilmaz, Gokhan; Topal, Firdes; Erbas, Oytun (Asian Network Scientific Information-Ansinet, 2024)Background and Objective: Cisplatin, a widely used chemotherapeutic agent, is associated with significant nephrotoxicity, leading to Acute Kidney Injury (AKI). Astragaloside IV (AS-IV), a compound derived from Radix ... -
Intranasal Insulin Eases Autism in Rats via GDF-15 and Anti-Inflammatory Pathways
Arda, Duygu Burcu; Tunc, Kerem Can; Bozkurt, Mehmet Fatih; Bora, Ejder Saylav; Cigel, Ayse; Erbas, Oytun (Mdpi, 2024)In rat models, it is well-documented that chronic administration of propionic acid (PPA) leads to autism-like behaviors. Although the intranasal (IN) insulin approach is predominantly recognized for its effects on food ... -
Oxytocin: A Shield against Radiation-Induced Lung Injury in Rats
Kayali, Ahmet; Arda, Duygu Burcu; Bora, Ejder Saylav; Uyanikgil, Yigit; Atasoy, Ozum; Erbas, Oytun (Mdpi, 2024)Background: Radiation-induced lung injury (RILI), a serious side effect of thoracic radiotherapy, can lead to acute radiation pneumonitis (RP) and chronic pulmonary fibrosis (PF). Despite various interventions, no effective ... -
Protective effect of dapagliflozin on colistin-induced renal toxicity
Bora, Ejder Saylav; Erdogan, Mumin Alper; Meral, Ayfer; Karakaya, Zeynep; Erbas, Oytun (Mre Press, 2021)Objectives: Multiple-drug resistance to Gram-negative bacteria has increased significantly in recent years. Colistin is increasingly used as a last line of defense against these bacteria. However, colistin has been associated ... -
Research Article Nasal Oxytocin's Anticonvulsant Effects on Pentylenetetrazolinduced Convulsions in Rats
Bora, Ejder Saylav; Erdogan, Mumin Alper; Karaali, Rezan; Cakir, Adem; Erbas, Oytun (Asian Network Scientific Information-Ansinet, 2023)Background and Objective: Neurodegenerative proteins and pro-inflammatory mechanisms may cause epilepsy through excitatory-inhibitory imbalance. Drug resistance is common, therefore this disease requires affordable, ... -
Roxadustat protects rats from cisplatin-induced acute kidney injury
Arikan, Cuneyt; Bora, Ejder Saylav; Arda, Duygu Burcu; Erbas, Oytun (Pharmacotherapy Group, 2024)Purpose: To investigate the potential protective effect of roxadustat against cisplatin-induced acute kidney injury (AKI) by evaluating biochemical markers, inflammatory parameters, renal function tests, and histopathological ... -
Short term protective effect of digitoxin in sepsis-induced acute lung injury
Bora, Ejder Saylav; Erdogan, MuMIN Alper; Ozkul, Bahattin; Sever, Ibrahim Halil; Sogut, Ibrahim; Hurdag, Canan; Erbas, Oytun (Tech Science Press, 2022)Purpose: Digitoxin is a cardiac glycoside used in the treatment of heart failure. Inspired by its known antiinflammatory effect, this study aims to investigate the effect of digoxin in a sepsis model and to bring to light ...
