Yazar "Erbas, O." için listeleme
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Adipose-derived mesenchymal stem cells mitigate methotrexate-induced liver cirrhosis (fibrosis) model
Sorgun, O.; Erbas, O. (Verduci Publisher, 2023)OBJECTIVE: Hepatic fibrosis is a severe liver condition characterized by abnormal fibroblast activity, excessive extracellular matrix deposition, inflammation, and structural alterations. Methotrexate (MTX), a pharmaceutical ... -
Anti-inflammatory and antioxidant properties of betaine protect against sepsis-induced acute lung injury: CT and histological evidence
Sorgun, O.; Cakir, A.; Bora, E. S.; Erdogan, M. A.; Uyanikgil, Y.; Erbas, O. (Assoc Bras Divulg Cientifica, 2023)The aim of this research was to determine the anti-inflammatory effect of betaine on sepsis-induced acute respiratory distress syndrome (ARDS) in rats through histopathological examination, radiologic imaging, and biochemical ... -
The Anti-Seizure Effect of Liraglutide on Ptz-Induced Convulsions Through its Anti-Oxidant and Anti-Inflammatory Properties
Erdogan, M.A.; Erdogan, A.; Erbas, O. (Springer, 2022)Epilepsy is a prevalent and frequently devastating neurological disorder defined by recurring spontaneous seizures caused by aberrant electrical activity in the brain. Over ten million people worldwide suffer from ... -
Candesartan protects from cisplatin-induced kidney damage via the GDF-15 pathway
OBJECTIVE: The aim of this study was to explore the protective effect of candesartan against cisplatin-induced kidney damage, with a specific focus on the growth differentiation factor 15 (GDF-15) pathway. MATERIALS AND ... -
Cardio-protective effect of dapagliflozin against doxorubicin induced cardiomyopathy in rats
Belen, E.; Canbolat, I. P.; Yigitturk, G.; Cetinarslan, O.; Akdeniz, C. S.; Karaca, M.; Erbas, O. (Verduci Publisher, 2022)OBJECTIVE: Cancer is the second most common non-communicable disease group in the world and its frequency is increasing. In parallel, side effects of drugs used in cancer treatment are frequently encountered. Doxorubicin ... -
Demonstration of the protective effect of ghrelin in the livers of rats with cisplatin toxicity
Bademci, R.; Erdogan, M. A.; Eroglu, E.; Meral, A.; Erdogan, A.; Atasoy, O.; Erbas, O. (Sage Publications Ltd, 2021)Despite the various and newly developed chemotherapeutic agents in recent years, cisplatin is still used very frequently as a chemotherapeutic agent, even though cisplatin has toxic effects on many organs. The aim of our ... -
Effect of fluid resuscitation on acute lung injury in a rat model of sepsis
Erdogan, A.; Erdogan, M.A.; Kara, A.Y.; Bora, S.; Yigitturk, G.; Erbas, O. (Comenius University in Bratislava, 2021)Aim: Sepsis is a systemic infection reaction and intravascular volume therapy plays a crucial role in it’s treatment. Acute respiratory distress syndrome (ARDS) occurs in the lungs, the most affected organ. This study aimed ... -
The effect of sulfasalazine in pentylenetetrazole-induced seizures in rats
Bora, E. S.; Karaali, R.; Akyol, P. Y.; Yurtsever, G.; Erbas, O. (Assoc Bras Divulg Cientifica, 2021)We aimed to reveal the anti-convulsant effects sulfasalazine and its mechanism in pentylenetetrazole (PTZ)-induced seizures in rats. Forty-eight male Wistar albino rats (200-250 g) were randomly divided into two groups: ... -
The effects of methylene blue and tadalafil in pentylenetetrazole induced convulsion model
Solmaz, V.; Aksoy, D.; Yurtogullari, S.; Semiz, M.; Aydemir, E.; Erbas, O. (Gulhane Medical School, University of Health Sciences, 2016)L-arginine (L-ARG)-nitric oxide (NO)-cGMP (cyclic guanosine monophosphate) cycle has been determined in various studies to be associated with epilepsy. Tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5) and ... -
Effects of trimetazidine on nerve regeneration in a rat sciatic nerve injury model
Karahan, G.; Kaya, H.; Erdogan, M. A.; Yigitturk, G.; Gokyayla, E.; Erbas, O. (Comenius Univ, 2019)AIM: the aim of this study was to evaluate the efficacy of trimetazidine(TMZ) after end-to-end repair in a peripheral nerve injury model. METHOD: We performed end-to-end primary repair of sciatic nerves in rats and showed ... -
Hydroxychloroquine Mitigates Cytokine Storm and Prevents Critical Illness Neuromyopathy in a Rat Sepsis Model
Eygi, E.; Kucuk, O.; Aydemir, S.; Atilgan, M.; Dokuyucu, R.; Erbas, O. (Multidisciplinary Digital Publishing Institute (MDPI), 2024)Background and Objectives: It is known that critical illness and associated neuromuscular problems begin to appear in patients hospitalized in the intensive care unit (ICU) for more than a week. The goal of this study was ... -
The long pentraxin-3 is a useful marker for diagnosis of ovarian torsion: An experimental rat model
Akman, L.; Erbas, O.; Terek, M. C.; Aktug, H.; Taskiran, D.; Askar, N. (TAYLOR & FRANCIS INC, 2016)Pentraxin-3 (PTX3) plays an important role in the primary inflammatory response. We aim to evaluate PTX3 as a diagnostic marker of ovarian torsion in an experimental rat model. In this study, 16 female Sprague Dawley albino ... -
Nephro-protective effect of granulocyte colony-stimulating factor in streptozotocin induced diabetic rats
Erbas, O.; Yapislar, H.; Oltulu, F.; Yavasoglu, A.; Aktug, H.; Taskiran, D. (INFORMA HEALTHCARE, 2014)Diabetic nephropathy is one of the most serious complications of diabetes and the major cause of end-stage renal failure. Consequences of diabetic nephropathy include increased kidney size and glomerular volume, thickening ... -
Oxytocin and cabergoline alleviate ovarian hyperstimulation syndrome (OHSS) by suppressing vascular endothelial growth factor (VEGF) in an experimental model
Hortu, I.; Karadadas, E.; Ozceltik, G.; Tavmergen, E.; Tavmergen Goker, E.N.; Yigitturk, G.; Erbas, O. (Springer Science and Business Media Deutschland GmbH, 2021)Purpose: Ovarian hyperstimulation syndrome (OHSS) is a life-threatening complication of ovarian stimulation in reproductive medicine. Here, we aimed to investigate the role of oxytocin (OT) and cabergoline in the prevention ... -
Oxytocin mitigates peripheral nerve damage via Nrf2 and irisin pathway
Tosyali, H. K.; Bora, E. S.; Cinaroglu, O. S.; Erbas, O. (Verduci Publisher, 2023)OBJECTIVE: Peripheral nerve injuries present challenges in achieving full functional restoration, necessitating effective therapeutic strategies. Oxytocin, known for its neuroprotective and anti-inflammatory properties, ... -
The Protective Effect of Losartan on Diabetic Neuropathy in a Diabetic Rat Model
Cavusoglu, T.; Karadeniz, T.; Cagiltay, E.; Karadeniz, M.; Yigitturk, G.; Acikgoz, E.; Erbas, O. (JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH, 2015)Aim: Involvement of the peripheral and autonomic nervous systems is possibly the most frequent complication of diabetes. Important risk factors included hyperglycemia, dyslipidemia, hypertension, and smoking. Angiotensin ... -
Radiotherapy and high bilirubin may be metformin like effect on lung cancer via possible AMPK pathway modulation
Atasoy, O.; Cini, N.; Erdogan, M. A.; Yaprak, G.; Erbas, O. (Aepress Sro, 2022)PURPOSE: L ife expectancy of cancer patients determine the regimen of treatment. There is no feasible marker that determines the survival other than the stage of the disease or other patients related factors. Bilirubin can ... -
Saccharomyces boulardii Mitigates Fructose-Induced Non-Alcoholic Fatty Liver in Rats
Ulusan, M.; Erdogan, M.A.; Simsek, O.; Gunes, V.; Erbas, O. (Multidisciplinary Digital Publishing Institute (MDPI), 2024)Background and Objectives: Non-alcoholic fatty liver disease (NAFLD) is a growing global health concern closely linked to metabolic disorders, including obesity, insulin resistance, and dyslipidemia. Emerging evidence ... -
Sulfasalazine prevents lung injury due to intra-abdominal sepsis in rats: possible role of Nrf2 and angiopoietin-2
Dibekoglu, C.; Uyanikgil, Y.; Erbas, O. (Assoc Bras Divulg Cientifica, 2023)This study aimed to investigate the effect of sulfasalazine in preventing and treating intra-abdominal sepsis-induced acute respiratory distress syndrome (ARDS) in a rat model. Forty male Wistar albino rats were used. The ...
