Yazar "Erbas, Oytun" için listeleme
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Accumulation of alpha-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers
Solmaz, Volkan; Ozlece, Hatice Kose; Eroglu, Huseyin Avni; Aktug, Huseyin; Erbas, Oytun; Taskiran, Dilek (HINDAWI PUBLISHING CORP, 2017)Objective. The present study was conducted to evaluate the relationship between plasma oxidative stress markers such as malondialdehyde (MDA) and glutathione (GSH), inflammatory marker pentraxin-3 (PTX3), and cerebellar ... -
Administration of low dose intranasal ketamine exerts a neuroprotective effect on whole brain irradiation injury model in wistar rats
Yaprak, Gokhan; Cini, Nilsu; Atasoy, Ozum Buke; Uyanikgil, Yigit; Erdogan, Mumin Alper; Erbas, Oytun (Springer, 2024)Exposure to ionizing radiation leads to oxidative stress and neuroinflammation, resulting in neurocognitive impairments. Adverse effects are also associated with glutamate-induced excitotoxicity due to alterations in the ... -
Ameliorating Effect of Propofol on Cisplatin -Induced Liver and Kidney Damage in Rats
Ozkul, Ozlem; Ozkul, Bahattin; Erdogan, Mumin Alper; Erbas, Oytun (Asian Network Scientific Information-Ansinet, 2022)Background and Objective: Cisplatin is among the most frequently used in solid organ cancers. However, it can be dose-limiting, especially due to its side effects on the kidney and liver. This study aims to examine the ... -
Amelioration of propionic acid-induced autism spectrum disorder in rats through dapagliflozin: The role of IGF-1/IGFBP-3 and the Nrf2 antioxidant pathway
Erdogan, Mumin Alper; Nesil, Pemra; Altuntas, Ilknur; Sirin, Cansin; Uyanikgil, Yigit; Erbas, Oytun (Pergamon-Elsevier Science Ltd, 2024)The biological effects of dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, reveal its antioxidant and anti-inflammatory properties, suggesting therapeutic benefits beyond glycemic control. This study ... -
Amelioration of propionic acid-induced autism-like behaviors in rats by fenofibrate: A focus on reduction of brain galectin-3 levels
Erdogan, Mumin Alper; Akbulut, Mine Ceren; Altuntas, Ilknur; Tomruk, Canberk; Uyanikgil, Yigit; Erbas, Oytun (Wiley, 2024)IntroductionAutism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions and repetitive behaviors. This study examines the effects of fenofibrate on a propionic acid ... -
The Ameliorative Effects of Ascorbic Acid on Critical Illness Polyneuropathy in Rodent Sepsis Model
Sunnetci Silistre, Eda; Erbas, Oytun (Georg Thieme Verlag Kg, 2020)Although the exact pathophysiology of critical illness polyneuropathy (CIP) is still unknown, there are several hypotheses, some of which are increased inflammation and oxidative stress. We used rodent sepsis model in which ... -
Antifibrotic Effect of Lactulose on a Methotrexate-Induced Liver Injury Model
Taskin, Banu; Erdogan, Mumin Alper; Yigitturk, Gurkan; Gunenc, Damla; Erbas, Oytun (HINDAWI LTD, 2017)The most severe side effect of prolonged MTX treatment is hepatotoxicity. The aim of this study is to investigate the effect of lactulose treatment on MTX-induced hepatotoxicity in a rat model. Twenty-four male rats were ... -
Antifibrotic preventive effect of polyethylene glycol (PEG) 3350 in methotrexate-induced hepatoxicity model
Acar, Huseyin; Sorgun, Omay; Yurtseve, Guner; Bora, Ejder Saylav; Erbas, Oytun (Acta Cirurgica Brasileira, 2022)Purpose: Liver damage caused by drugs and other chemicals accounts for about 5% of all cases. Methotrexate (MTX), a folic acid analogue, is a first-line synthetic antimetabolite agent routinely used in the treatment of ... -
The antioxidant role of agomelatine and gallic acid on oxidative stress in STZ induced type I diabetic rat testes
Yigitturk, Gurkan; Acara, Ahmet Cagdas; Erbas, Oytun; Oltulu, Fatih; Yavasoglu, Nefise Ulku Karabay; Uysal, Aysegul; Yavasoglu, Altug (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017)Diabetes is a multisystem disorder and its effects are observed on the reproductive system. One of the main causes of testicular tissue damage is diabetes-induced overproduction of reactive oxygen species and glycated end ... -
Antipsychotic Like Effects of Atorvastatin and Melatonin in a Psychosis Model in Rats
Solmaz, Volkan; Delibas, Dursun Hakan; Inanir, Sema; Erbas, Oytun (YERKURE TANITIM & YAYINCILIK HIZMETLERI A S, 2015)Objective: In recent years besides dopaminergic imbalance exhibition of other possible mechanisms like inflammation and serotonergic abnormalities have pointed out the need for new antipsychotic drugs. In this study our ... -
Atorvastatin has therapeutic potential for the fatty liver-induced memory dysfunction in rats, likely via its antioxidant and anti-inflammatory properties
Solmaz, Volkan; Atasoy, Ozum; Erbas, Oytun (Taylor & Francis Ltd, 2020)This study aimed to evaluate the memory function in a rat model of fatty liver and to investigate the effects of statins on fatty liver, neuronal inflammation, oxidative stress and memory. in this study, 24 male rats were ... -
Autophagy and anti-inflammation ameliorate diabetic neuropathy with Rilmenidine
Yalcin, Mehmet Burak; Bora, Ejder Saylav; Cakir, Adem; Akbulut, Sabiye; Erbas, Oytun (Acta Cirurgica Brasileira, 2023)Purpose: To evaluate the neuroprotective effects of Rilmenidine on diabetic peripheral neuropathy (DPN) in a rat model of diabetes induced by streptozotocin (STZ). Methods: STZ (60 mg/kg) was administered to adult ... -
Beneficial effects of agomelatine in experimental model of sepsis-related acute kidney injury
Basol, Nursah; Erbas, Oytun; Cavusoglu, Turker; Meral, Ayfer; Ates, Utku (TURKISH ASSOC TRAUMA EMERGENCY SURGERY, 2016)BACKGROUND: Sepsis-related acute kidney injury (AKI) is a serious complication of sepsis. Problems persist regarding early diagnosis and treatment of AKI. The aim of the present study was to evaluate the efficacy of ... -
Beneficial Effects of Ibuprofen on Pentylenetetrazol-induced Convulsion
Durankus, Ferit; Senkal, Evrim; Sunnetci, Eda; Albayrak, Yakup; Beyazyuz, Murat; Atasoy, Ozum; Erbas, Oytun (Springer/Plenum Publishers, 2020)Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used as an anti-inflammatory, anti-pyretic, and analgesic. Although some studies have focused on the anti-inflammatory and anti-pyretic properties ... -
Beneficial effects of IVIG treatment on experimental-induced
Ozdemir, Savas; Erbas, Oytun (Mexican Acad Surgery, 2024)Objective: Estrogen (E2) plays a significant role in postmenopausal osteoporosis, and its deficiency is related to chronic lowgrade inflammation. Intravenous immunoglobulin (IVIG) is composed of immunoglobulins derived ... -
Caffeine mitigates tamoxifen-induced fatty liver in Wistar rats
Sezgin, Yasin; Bora, Ejder Saylav; Arda, Duygu Burcu; Uyanikgil, Yigit; Erbas, Oytun (Acta Cirurgica Brasileira, 2024)Purpose: Tamoxifen, a widely used drug for breast cancer treatment, is associated with adverse effects on the liver, including the development of fatty liver. This study aimed to investigate the potential protective effect ... -
Choline chloride shows gender-dependent positive effects on social deficits, learning/memory impairments, neuronal loss and neuroinflammation in the lipopolysaccharide-induced rat model of autism
Egilmez, Cansu Bilister; Pazarlar, Burcu Azak; Erdogan, Mumin Alper; Uyanikgil, Yigit; Erbas, Oytun (Wiley, 2024)The neuroprotective effects of choline chloride, an essential nutrient, a precursor for the acetylcholine and synthesis of membrane phospholipids, have been associated with neurological and neurodegenerative diseases. Its ... -
Comparison of the Effects of Extracorporeal Irradiation and Liquid Nitrogen on Nerve Recovery in a Rat Model
Kaya, Huseyin; Sabah, Dundar; Kececi, Burcin; Kucuk, Levent; Erbas, Oytun; Oltulu, Fatih; Taskiran, DilekAim of the study: Biologic reconstruction using tumor-bearing bone autografts devitalized by liquid nitrogen or extracorporeal irradiation (oncological sterilization) is a safe and effective method in musculoskeletal ... -
Demonstration of ameliorating effect of vardenafil through its anti-inflammatory and neuroprotective properties in autism spectrum disorder induced by propionic acid on rat model
Ozkul, Bahattin; Urfali, Furkan Erturk; Sever, Ibrahim Halil; Bozkurt, Mehmet Fatih; Sogut, Ibrahim; Elgormus, Cagri Serdar; Erbas, Oytun (Taylor & Francis Ltd, 2022)Introduction Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex etiology. In this study, we aimed to determine the ameliorating effects of vardenafil in the ASD rat model induced by propionic acid ... -
Demonstration of the protective effect of propofol in rat model of cisplatin-induced neuropathy
Gonullu, Edip; Dagistan, Gozde; Erkin, Yuksel; Erdogan, Mumin Alper; Erbas, Oytun (Aepress Sro, 2023)Cisplatin is commonly used in the treatment of lung, genitourinary, and gastrointestinal cancers. Peripheral neuropathy is the most important side effect, leading to a decrease in the dose of cisplatin or its complete ...
