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The antioxidant and antiapoptotic effect of boric acid on hepatoxicity in chronic alcohol-fed rats
Sogut, Ibrahim; Paltun, Sila Ozlem; Tuncdemir, Matem; Ersoz, Melike; Hurdag, Canan (CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS, 2018)The harmful use of alcohol is a worldwide problem involving all ages. This study aims to investigate chronic alcohol exposure related hepatotoxicity on the rat liver and possible hepatoprotective effects of boric acid. ... -
Comparative evaluation of hesperetin loaded nanoparticles for anticancer activity against C6 glioma cancer cells
Ersoz, Melike; Erdemir, Aysegul; Duranoglu, Dilek; Uzunoglu, Deniz; Arasoglu, Tulin; Derman, Serap; Mansuroglu, Banu (TAYLOR & FRANCIS LTD, 2019)The aim of this study was to evaluate anti-cancer properties of hesperetin (Hsp) and hesperetin-loaded poly(lactic-co-glycolic acid) nanoparticles (HspNPs) for glioblastoma treatment. Nanoparticles prepared by single ... -
Cytotoxic and apoptotic effects of ethanolic propolis extract on C6 glioma cells
Coskun, Zeynep M.; Ersoz, Melike; Gecili, Melike; Ozden, Aytek; Acar, Aynur (Wiley, 2020)Propolis is a natural resinous substance obtained from beehives, and emerging evidence supports that it has antitumor, antiinflammatory, antioxidant, and antimicrobial activities. the aim of the study is to examine the ... -
Effects of boric-acid-applied green tea on the expressions of heat shock proteins in MCF-7 cells
Ersoz, Melike; Kacar, Ayse Karatug; Sezekler, Isil; Coskun, Zeynep Mine (CUKUROVA UNIV, FAC MEDICINE, 2019)Purpose: The study aims to examine the effects of boric acid at different concentrations applied to green tea on heat shock protein (HSP) 70 and HSP 90 in MCF-7 cells. Materials and Methods: Boric acid in sodium tetraborate ... -
Effects of gallic acid on expressions of MMP-2 and MMP-9 through the pathway of p38/JNK in C6 glioma cells
Yaka, Ebru Bellioglu; Yazici, Zeynep Mine Coskun; Ersoz, Melike; Gulsoy, Nagihan (Univ Karachi, 2023)In our study, the effects of gallic acid (GA), a natural therapeutic agent, on oxidative stress biomarkers and MMP-2 and MMP-9 expressions via the p38/JNK pathway in C6 glioma cells were investigated. The toxicity of GA ... -
Investigation of the biochemical and apoptotic changes in breast cancer cells treated with leaf extract from tea (Camellia sinensis L.) grown with added boric acid
Sezekler, Isil; Ersoz, Melike; Turan, Murat Ali; Coskun, Zeynep Mine (Univ Karachi, 2020)Tea obtained from the leaves of Camellia sinensis L., a medicinal plant, is a widely popular beverage. Deficiency in boron, a micronutrient for C. sinensis, affects the growth as well as the quality of tea. the aim of this ... -
Quercetin-loaded nanoparticles enhance cytotoxicity and antioxidant activity on C6 glioma cells
Ersoz, Melike; Erdemir, Aysegul; Derman, Serap; Arasoglu, Tulin; Mansuroglu, Banu (Taylor & Francis Ltd, 2020)Quercetin (Qu) is a natural flavonoid present in many commonly consumed food items. the dietary phytochemical quercetin prevents tumor proliferation and is a potent therapeutic cancer agent. the purpose of this study was ... -
Screening of Antimicrobial Activity and Cytotoxic Effects of Two Cladonia Species
Acikgoz, Birkan; Karalti, Iskender; Ersoz, Melike; Coskun, Zeynep M.; Cobanoglu, Gulsah; Sesal, Cenk (VERLAG Z NATURFORSCH, 2013)The present study explores the antimicrobial activity and cytotoxic effects in culture assays of two fruticose soil lichens, Cladonia rangiformis Hoffm. and Cladonia convoluta (Lamkey) Cout., to contribute to possible ...
