Yazar "Onat, Filiz" için listeleme
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Atipamezole, a specific alpha(2A) antagonist, suppresses spike-and-wave discharges and alters Ca2+/calmodulin-dependent protein kinase II in the thalamus of genetic absence epilepsy rats
Objective the role of alpha(2A) adrenergic receptors (alpha(2A)ARs) in absence epilepsy is not well characterized. Therefore, we investigated the outcomes of the specific antagonism of alpha(2A)ARs on the spike-and-wave ... -
The effect of chronic treatment with sodium channel blocker lacosamide on early development of absence seizures in genetic absence epilepsy rats
Carcak, Nihan; Karanfil, Ceren; Akat, Sura; Akman, Ozlem; Onat, Filiz (Elsevier, 2022)Objective: Lacosamide (LCM) is a new generation antiepileptic drug that affects the slow inactivation of voltagegated sodium channels. We studied whether chronic LCM treatment prior to onset of absence seizures was able ... -
Evaluation of GAD67 immunoreactivity in the region of substantia nigra pars reticulata in resistance to development of convulsive seizure in genetic absence epilepsy rats
Gulcebi, Medine; Akman, Ozlem; Carcak, Nihan; Karamahmutoglu, Tugba; Onat, Filiz (KARE PUBL, 2016)OBJECTIVE: Nonconvulsive absence epilepsy and convulsive epilepsy seizures are rarely seen in the same patient. It has been demonstrated that there is a resistance to development of convulsive seizures in genetic absence ... -
The gamma-butyrolactone model of absence epilepsy: acute and chronic effects in wistar rats
Karamahmutoğlu, Tuğba Eryiğit; Çarçak, Nihan; Şahiner, Melike; Akman, Özlem; Snead, O. Carter; Eşkazan, Esat; Onat, Filiz (Türk Epilepsi ile Savaş Derneği, 2013)Objective: We studied the electroencephalographic (EEG) and behavioral changes of the chemical model of generalized absence epilepsy induced by acute and chronic administration of gamma-butrolactone (GBL), a prodrug of ... -
The gamma-butyrolactone model of absence epilepsy: Acute and chronic effects in wistar rats
Karamahmutoğlu, Tuğba Eryiğit; Çarçak, Nihan; Şahiner, Melike; Akman, Özlem; Snead, O. Carter; Eşkazan, Esat; Onat, Filiz (Türk Epilepsi İle Savaş Derneği, 2013)Introduction A pharmacological modeling approach to absence epilepsy requires a reproducible and predictable method that has the EEG and behavioral characteristics of generalized typical absence seizures in humans. The ... -
Genetik absans epilepsili sıçanlarda substansiya nigra ve striatumdaki dopaminerjik nöronların dansitometrik analizi
WAG/Rij ırkı sıçanlar tipik absans epilepsinin iyi tanımlanmış modellerinden biridir. Son yıllarda yapılan çalışmalarda absans epilepside dopaminerjik sistemin bozukluğunun rol oynadığı ileri sürülmektedir. Orta beyin ... -
Pharmacologically induced absence seizures versus kindling in Wistar rats
Carcak, Nihan; Sahiner, Melike; Akman, Ozlem; Idrizoglu, Medine Gulcebi; Cortez, Miguel A.; Snead, O. Carter; Onat, Filiz (Kare Publ, 2020)OBJECTIVE: This study aimed to investigate the effects of gamma-butyrolactone (GBL), a prodrug of gamma-Hydroxybutyric acid-induced absence seizures on the development of kindling in Wistar rats. METHODS: Three groups of ... -
Voltaj bağımlı kalsiyum kanal α-1G altünite ekspresyonunun genetik absans epilepisili sıçanlarda değerlendirilmesi
Akın, Demet; Ketenci, Sema; Sırvancı, Serap; Onat, Filiz (2011)Amaç: T tipi voltaj bağımlı kalsiyum kanalları absans epilepsy etyopatogenezinde önemli rol oynamaktadır. Talamokortikal döngü genetik absans epilepsili sıçanlarda (GAERS) diken-dalga deşarjlarının ortaya çıkmasında önemli ...
