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Choline chloride shows gender-dependent positive effects on social deficits, learning/memory impairments, neuronal loss and neuroinflammation in the lipopolysaccharide-induced rat model of autism
Egilmez, Cansu Bilister; Pazarlar, Burcu Azak; Erdogan, Mumin Alper; Uyanikgil, Yigit; Erbas, Oytun (Wiley, 2024)The neuroprotective effects of choline chloride, an essential nutrient, a precursor for the acetylcholine and synthesis of membrane phospholipids, have been associated with neurological and neurodegenerative diseases. Its ... -
Immunosuppressant Tacrolimus Treatment Delays Acute Seizure Occurrence, Reduces Elevated Oxidative Stress, and Reverses PGF2? Burst in the Brain of PTZ-Treated Rats
Pazarlar, Burcu Azak; Egilmez, Cansu Bilister; Erdogan, Mumin Alper; Erbas, Oytun (Springer/Plenum Publishers, 2023)It is still an urgent need to find alternative and effective therapies to combat epileptic seizures. Tacrolimus as a potent immunosuppressant and calcineurin inhibitor is emerging as promising drug to suppress seizures. ... -
N-acetyl cysteine: A new look at its effect on PTZ-induced convulsions
Egilmez, Cansu Bilister; Pazarlar, Burcu Azak; Erdogan, Mumin Alper; Erbas, Oytun (Elsevier, 2023)Introduction/Aim: Epilepsy is widely investigated as a common neurological disease requiring pharmacologically effective agents. N-acetyl cysteine (NAC), has become a remarkable molecule with its role in both antioxidant ... -
Neuroprotective effect of dexpanthenol on rotenone-induced Parkinson's disease model in rats
Egilmez, Cansu Bilister; Pazarlar, Burcu Azak; Erdogan, Mumin Alper; Erbas, Oytun (Elsevier Ireland Ltd, 2024)Parkinson's disease (PD) is the second most common and progressive neurodegenerative disease. This experimental study was designed to investigate the neuroprotective effects of dexpanthenol on antioxidant and antiinflammatory ...
