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Amelioration of propionic acid-induced autism spectrum disorder in rats through dapagliflozin: The role of IGF-1/IGFBP-3 and the Nrf2 antioxidant pathway
Erdogan, Mumin Alper; Nesil, Pemra; Altuntas, Ilknur; Sirin, Cansin; Uyanikgil, Yigit; Erbas, Oytun (Pergamon-Elsevier Science Ltd, 2024)The biological effects of dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, reveal its antioxidant and anti-inflammatory properties, suggesting therapeutic benefits beyond glycemic control. This study ... -
Effects of vitrification solution supplemented with platelet-rich plasma in rat ovarian tissue cryopreservation
Gokhan, Aylin; Cavusoglu, Tuerker; Kilic, Kubilay Dogan; Sirin, Cansin; Tomruk, Canberk; Yigitturk, Guerkan; Erbas, Oytun (Tubitak Scientific & Technological Research Council Turkey, 2023)Background/aim: The subject of this study was to investigate the utility of platelet-rich plasma (PRP) in the cryopreservation process to reduce cryodamage and increase tissue viability.Materials and methods: Twenty-one ... -
Preventive effect of trimetazidine against ischemia-reperfusion injury in rat epigastric island flaps: an experimental study
Akdemir, Ovunc; Tatar, Burak Ergun; Gokhan, Aylin; Sirin, Cansin; Cavusoglu, Turker; Erbas, Oytun; Lineaweaver, WilliamBackground For plastic surgery, ischemia-reperfusion (I-R) injury is a critical problem that results in partial or total flap necrosis. Trimetazidine (TMZ) is a drug used in the treatment of angina pectoris. This study ... -
Reparative, Neuroprotective and Anti-Neurodegenerative Effects of Granulocyte Colony Stimulating Factor in Radiation-Induced Brain Injury Model
Gurkan, Goekhan; Atasoy, Ozum; Cini, Nilsu; Sever, Ibrahim Halil; Ozkul, Bahattin; Yaprak, Gokhan; Sirin, Cansin (Korean Neurosurgical Soc, 2023)Objective : This animal model aimed to compare the rat group that received brain irradiation and did not receive additional treatment (only saline) and the rat group that underwent brain irradiation and received Granulocyte ...