Yazar "Solmaz, Volkan" için listeleme
-
Accumulation of alpha-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers
Solmaz, Volkan; Ozlece, Hatice Kose; Eroglu, Huseyin Avni; Aktug, Huseyin; Erbas, Oytun; Taskiran, Dilek (HINDAWI PUBLISHING CORP, 2017)Objective. The present study was conducted to evaluate the relationship between plasma oxidative stress markers such as malondialdehyde (MDA) and glutathione (GSH), inflammatory marker pentraxin-3 (PTX3), and cerebellar ... -
Antipsychotic Like Effects of Atorvastatin and Melatonin in a Psychosis Model in Rats
Solmaz, Volkan; Delibas, Dursun Hakan; Inanir, Sema; Erbas, Oytun (YERKURE TANITIM & YAYINCILIK HIZMETLERI A S, 2015)Objective: In recent years besides dopaminergic imbalance exhibition of other possible mechanisms like inflammation and serotonergic abnormalities have pointed out the need for new antipsychotic drugs. In this study our ... -
Antipsychotic-like effect of agomelatine in a rodent model
Erbaş, Oytun; Eliküçük, Betül; Solmaz, Volkan; Akseki, Hüseyin Serdar; Semiz, Murat (Yerküre Tanıtım ve Yayıncılık Hizmetleri, 2015)Objective: Agomelatine is a naphthalene bioisostere of melatonin. Melatonin is involved in several neurophysiological systems; nevertheless, data about the relationship between melatonin and psychosis such as schizophrenia ... -
Atorvastatin has therapeutic potential for the fatty liver-induced memory dysfunction in rats, likely via its antioxidant and anti-inflammatory properties
Solmaz, Volkan; Atasoy, Ozum; Erbas, Oytun (Taylor & Francis Ltd, 2020)This study aimed to evaluate the memory function in a rat model of fatty liver and to investigate the effects of statins on fatty liver, neuronal inflammation, oxidative stress and memory. in this study, 24 male rats were ... -
Beneficial effects of ambroxol hydrochloride on pentylenetetrazol-induced convulsion model in rats
In present experimental study, we purposed to research if ambroxol would have beneficial acute effects on PTZ-induced convulsions by EEG records. 48 rats were ran?domly divided into two groups; group A for EEG recordings ... -
Erythropoietin shows gender dependent positive effects on social deficits, learning/memory impairments, neuronal loss and neuroinflammation in the lipopolysaccharide induced rat model of autism
Solmaz, Volkan; Erdogan, Mumin Alper; Alnak, Alper; Meral, Ayfer; Erbas, Oytun (Churchill Livingstone, 2020)We aimed to evaluate the effects of EPO in the lipopolysaccharide (LPS) induced rat model of autism in terms of social deficits, learning and memory impairments, as well as their neurochemical correlates. Sixteen female ... -
Evaluation of long-term effects of artificial sweeteners on rat brain: a biochemical, behavioral, and histological study
Erbas, Oytun; Erdogan, Mumin Alper; Khalilnezhad, Asghar; Solmaz, Volkan; Gurkan, Fulya Tuzcu; Yigitturk, Gurkan; Taskiran, Dilek (WILEY, 2018)The aim of the present study was to compare the effects of artificial sweeteners (aspartame, saccharin, and sucralose) on rat brain. Twenty-four adult male Sprague-Dawley rats were included in the study. The control group ... -
The evaluation of the therapeutic effect of memantine in sepsis induced critical illness polyneuropathy
Solmaz, Volkan; Piri Çınar, Bilge; Uyanıkgil, Yiğit; Çavuşoğlu, Türker; Peker, Gönül; Erbaş, Oytun (İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi Psikiyatri Kliniği, 2015)Objectives: The purpose of our study is to investigate the effects of the different dosage of memantine for the treatment of Critical Illness Polyneuropathy (CIP) in rats that have surgically induced sepsis, by using ... -
Exenatide reduces TNF-alpha expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats
Solmaz, Volkan; Cinar, Bilge Piri; Yigitturk, Gurkan; Cavusoglu, Turker; Taskiran, Dilek; Erbas, Oytun (ELSEVIER SCIENCE BV, 2015)Recent studies suggest a possible link between type 2 diabetes and Alzheimer's disease (AD). Glucoganlike peptide 1 (GLP-1) facilitates insulin release from pancreas under hyperglycemic conditions. In addition to its ... -
Exenatide, a GLP-1 analog, has healing effects on LPS-induced autism model: Inflammation, oxidative stress, gliosis, cerebral GABA, and serotonin interactions
Solmaz, Volkan; Tekatas, Aslan; Erdogan, Mumin Alper; Erbas, Oytun (Wiley, 2020)Previous studies have established anti-inflammatory, antioxidant, and neuroprotective effects of Exenatide in the central nervous system. Since these mechanisms are thought to have important roles in the pathophysiology ... -
Exposure to hypertonic solutions during pregnancy induces autism-like behaviors via the NFAT-5 pathway in offspring in a rat model
Senkal, Evrim; Bagcioglu, Erman; Eryigit, Umut; Erbas, Oytun; Solmaz, Volkan (Pergamon-Elsevier Science Ltd, 2021)Objectives: to investigate the effects of hyperosmolar state (HS) on immune response and inflammation via the NFAT5 pathway and examine whether immune-mediated conditions trigger autism-like behavior in offspring. Methods: ... -
Granulocyte colony-stimulating factor provides protection against cardiovascular autonomic neuropathy in streptozotocin-induced diabetes in rats
Erbas, Oytun; Solmaz, Volkan; Taskiran, Dilek (ELSEVIER IRELAND LTD, 2015)Aims: Cardiovascular autonomic neuropathy (CAN) is a relatively common and detrimental complication of diabetes mellitus (DM). Dysregulation of neuropeptides, such as calcitonin gene-related peptide (CGRP) and vasoactive ... -
Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy
Erdogan, Mumin Alper; Yusuf, Dimas; Christy, Joanna; Solmaz, Volkan; Erdogan, Arife; Taskiran, Emin; Erbas, Oytun (BIOMED CENTRAL LTD, 2018)Background: Worldwide, over 10 million individuals suffer from drug-resistant epilepsy. New therapeutic strategies are needed to address this debilitating disease. Inhibition of sodium-glucose linked transporters (SGLTs), ... -
Inhibitor effect of paricalcitol in rat model of pentylenetetrazol-induced seizures
Uyanikgil, Yigit; Solmaz, Volkan; Cavusoglu, Tuerker; Cinar, Bilge Piri; Cetin, Emel Oeykue; Sur, Halil YAnlmaz; Erbas, Oytun (SPRINGER, 2016)Vitamin D has various systemic effects on bone metabolism, modulation of the immune system, stabilization of the cell membrane, oxidative stress, inflammation, apoptosis, and various other hormones. Differing from active ... -
Mirtazapin ve paroksetin kullanımına bağlı gelişen huzursuz bacak sendromu
Solmaz, Volkan; Eser, Enes; Erbaş, Oytun (İstanbul Bilim Üniversitesi, Tıp Fakültesi, 2016)Huzursuz bacak sendromu (HBS) etyopatogenezi net olarak bilinmeyen, son yıllarda sıklığı giderek artan ve uyku düzenini ciddi şekilde etkileyerek yaşam kalitesini bozan bir hastalıktır. Bu yazıda, antidepresan ilaçların ... -
Modafinil Improves Autism-like Behavior in Rats by Reducing Neuroinflammation
Bagcioglu, Erman; Solmaz, Volkan; Erbas, Oytun; Ozkul, Bahattin; Cakar, Burak; Uyanikgil, Yigit; Sogut, Ibrahim (Springer, 2023)To evaluate the ameliorating effect of Modafinil on neuroinflammation, behavioral, and histopathological alterations in rats induced by propionic acid (PPA). Thirty male Wistar rats were used in the study, divided into 3 ... -
Montelukast inhibits pentylenetetrazol-induced seizures in rats.
Çevik, Betül; Solmaz, Volkan; Aksoy, Dürdane; Erbaş, Oytun (Medical Science International, 2015)Background: Montelukast is an antiinflammatory drug with an antioxidant property. In this study, we aimed to reveal whether montelukast has a preventive effect against seizures and post-seizure oxidative stress in ... -
Neuroprotective Effects of Eexenatide in a Rotenone-Induced Rat Model of Parkinson's Disease
Aksoy, Durdane; Solmaz, Volkan; Cavusoglu, Turker; Meral, Ayfer; Ates, Utku; Erbas, Oytun (ELSEVIER SCIENCE INC, 2017)Backround: Several studies suggest an association between Parkinson's disease (PD) and type 2 diabetes mellitus; these 2 diseases are both known to affect the common molecular pathways. As a synthetic agonist for the ... -
Neuroprotective effects of erythropoietin on Alzheimer's dementia model in rats
Cevik, Betul; Solmaz, Volkan; Yigitturk, Gurkan; Cavusoglu, Turker; Peker, Gonul; Erbas, Oytun (WROCLAW MEDICAL UNIV, 2017)Background. Although Alzheimer's disease (AD) is the most common age-related neurodegenerative disease and characterized by memory impairment, only symptomatic treatments are available. Objectives. Because recombinant human ... -
Neuroprotective effects of octreotide on diabetic neuropathy in rats
Solmaz, Volkan; Cinar, Bilge Piri; Yigitturk, Gurkan; Ozlece, Hatice Kose; Eroglu, Huseyin Avni; Tekatas, Aslan; Taskiran, Dilek (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017)The purpose of the present study is to investigate the possible healing effects of octreotide (OCT) on motor performance, electrophysiological and histopathological findings of diabetic neuropathy in a rat model of diabetes ...
