Yazar "Uyanikgil, Yigit" için listeleme
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Administration of low dose intranasal ketamine exerts a neuroprotective effect on whole brain irradiation injury model in wistar rats
Yaprak, Gokhan; Cini, Nilsu; Atasoy, Ozum Buke; Uyanikgil, Yigit; Erdogan, Mumin Alper; Erbas, Oytun (Springer, 2024)Exposure to ionizing radiation leads to oxidative stress and neuroinflammation, resulting in neurocognitive impairments. Adverse effects are also associated with glutamate-induced excitotoxicity due to alterations in the ... -
Amelioration of propionic acid-induced autism spectrum disorder in rats through dapagliflozin: The role of IGF-1/IGFBP-3 and the Nrf2 antioxidant pathway
Erdogan, Mumin Alper; Nesil, Pemra; Altuntas, Ilknur; Sirin, Cansin; Uyanikgil, Yigit; Erbas, Oytun (Pergamon-Elsevier Science Ltd, 2024)The biological effects of dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, reveal its antioxidant and anti-inflammatory properties, suggesting therapeutic benefits beyond glycemic control. This study ... -
Amelioration of propionic acid-induced autism-like behaviors in rats by fenofibrate: A focus on reduction of brain galectin-3 levels
Erdogan, Mumin Alper; Akbulut, Mine Ceren; Altuntas, Ilknur; Tomruk, Canberk; Uyanikgil, Yigit; Erbas, Oytun (Wiley, 2024)IntroductionAutism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions and repetitive behaviors. This study examines the effects of fenofibrate on a propionic acid ... -
Atorvastatin Improves the Propionic Acid- Induced Autism in Rats: The Roles of Sphingosine-1-Phosphate and Anti-inflammatory Action
Durankus, Ferit; Budak, Korkut; Albayrak, Yakup; Sever, Ibrahim H.; Ozkul, Bahattin; Uyanikgil, Yigit; Albayrak, Neslihan (Cureus Inc, 2023)Purpose The aim of this study is to investigate the benefits of atorvastatin on the propionic acid-induced autism model via increasing sphingosine-1-phosphate and anti-inflammatory actions with imaging and brain tissue ... -
Caffeine mitigates tamoxifen-induced fatty liver in Wistar rats
Sezgin, Yasin; Bora, Ejder Saylav; Arda, Duygu Burcu; Uyanikgil, Yigit; Erbas, Oytun (Acta Cirurgica Brasileira, 2024)Purpose: Tamoxifen, a widely used drug for breast cancer treatment, is associated with adverse effects on the liver, including the development of fatty liver. This study aimed to investigate the potential protective effect ... -
Choline chloride shows gender-dependent positive effects on social deficits, learning/memory impairments, neuronal loss and neuroinflammation in the lipopolysaccharide-induced rat model of autism
Egilmez, Cansu Bilister; Pazarlar, Burcu Azak; Erdogan, Mumin Alper; Uyanikgil, Yigit; Erbas, Oytun (Wiley, 2024)The neuroprotective effects of choline chloride, an essential nutrient, a precursor for the acetylcholine and synthesis of membrane phospholipids, have been associated with neurological and neurodegenerative diseases. Its ... -
Effect of platelet-rich plasma on reconstruction with nerve autografts
Teymur, Hakan; Tiftikcioglu, Yigit Ozer; Cavusoglu, Turker; Tiftikcioglu, Bedile Irem; Erbas, Oytun; Yigitturk, Gurkan; Uyanikgil, Yigit (ELSEVIER TAIWAN, 2017)Despite advances in understanding of peripheral nerve injuries and regeneration and advances in surgical techniques, successful outcomes cannot be guaranteed after reconstructive surgery. Platelet-rich plasma (PRP) has ... -
Inhibitor effect of paricalcitol in rat model of pentylenetetrazol-induced seizures
Uyanikgil, Yigit; Solmaz, Volkan; Cavusoglu, Tuerker; Cinar, Bilge Piri; Cetin, Emel Oeykue; Sur, Halil YAnlmaz; Erbas, Oytun (SPRINGER, 2016)Vitamin D has various systemic effects on bone metabolism, modulation of the immune system, stabilization of the cell membrane, oxidative stress, inflammation, apoptosis, and various other hormones. Differing from active ... -
Modafinil Improves Autism-like Behavior in Rats by Reducing Neuroinflammation
Bagcioglu, Erman; Solmaz, Volkan; Erbas, Oytun; Ozkul, Bahattin; Cakar, Burak; Uyanikgil, Yigit; Sogut, Ibrahim (Springer, 2023)To evaluate the ameliorating effect of Modafinil on neuroinflammation, behavioral, and histopathological alterations in rats induced by propionic acid (PPA). Thirty male Wistar rats were used in the study, divided into 3 ... -
Oxytocin: A Shield against Radiation-Induced Lung Injury in Rats
Kayali, Ahmet; Arda, Duygu Burcu; Bora, Ejder Saylav; Uyanikgil, Yigit; Atasoy, Ozum; Erbas, Oytun (Mdpi, 2024)Background: Radiation-induced lung injury (RILI), a serious side effect of thoracic radiotherapy, can lead to acute radiation pneumonitis (RP) and chronic pulmonary fibrosis (PF). Despite various interventions, no effective ... -
Rebaudioside A inhibits pentylenetetrazol-induced convulsions in rats
Uyanikgil, Yigit; Cavusoglu, Turker; Balcioglu, Huseyin A.; Gurgul, Serkan; Solmaz, Volkan; Ozlece, Hatice K.; Erbas, Oytun (ELSEVIER TAIWAN, 2016)The safety of patients with epilepsy consuming sweetening agents, which is becoming increasingly prevalent for various reasons, is a topic that should be emphasized as sensitively as it is for other diseases. Patients with ... -
Therapeutic effects of pentoxifylline in propionic acid-induced autism symptoms in rat models: A behavioral, biochemical, and histopathological study
Erdogan, Mumin Alper; Tunc, Kerem Can; Dastan, Ali Imran; Tomruk, Canberk; Uyanikgil, Yigit; Erbas, Oytun (Wiley, 2024)Objective: The role of propionic acid (PPA) in eliciting behaviors analogous to autism in rat models is a documented phenomenon. This study examines the therapeutic implications of pentoxifylline-an agent traditionally ...
