Konu "GAERS" için listeleme
Toplam kayıt 10, listelenen: 1-10
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Atipamezole, a specific alpha(2A) antagonist, suppresses spike-and-wave discharges and alters Ca2+/calmodulin-dependent protein kinase II in the thalamus of genetic absence epilepsy rats
Objective the role of alpha(2A) adrenergic receptors (alpha(2A)ARs) in absence epilepsy is not well characterized. Therefore, we investigated the outcomes of the specific antagonism of alpha(2A)ARs on the spike-and-wave ... -
The effect of chronic treatment with sodium channel blocker lacosamide on early development of absence seizures in genetic absence epilepsy rats
(Elsevier, 2022)Objective: Lacosamide (LCM) is a new generation antiepileptic drug that affects the slow inactivation of voltagegated sodium channels. We studied whether chronic LCM treatment prior to onset of absence seizures was able ... -
Electroencephalographic differences between WAG/Rij and GAERS rat models of absence epilepsy
(ELSEVIER SCIENCE BV, 2010)The inbred Wistar Albino Glaxo Rats from Rijswijk (WAG/Rij) and the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are well-validated genetic models of absence epilepsy. Although they share similar characteristics ... -
Electroencephalographic differences between WAG/Rij and GAERS rat models of absence epilepsy
(Elsevier Inc, 2010)The inbred Wistar Albino Glaxo Rats from Rijswijk (WAG/Rij) and the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are well-validated genetic models of absence epilepsy. Although they share similar characteristics ... -
Evaluation of GAD67 immunoreactivity in the region of substantia nigra pars reticulata in resistance to development of convulsive seizure in genetic absence epilepsy rats
(KARE PUBL, 2016)OBJECTIVE: Nonconvulsive absence epilepsy and convulsive epilepsy seizures are rarely seen in the same patient. It has been demonstrated that there is a resistance to development of convulsive seizures in genetic absence ... -
Genetik absans epilepsi sıçan modelindeki kindling direncinde substansiya nigra'nın rolü
(Bilimsel Tıp, 2010)“Genetic Absence Epilepsy Rats from Strasbourg (GAERS)” ırkı sıçanlar tipik absans epilepsinin iyi tanımlanmış modellerinden biridir. Son yıllarda yapılan çalışmalarda, bu ırkın amigdale, hippokampal ve peririnal kortikal ... -
Perirhinal cortical kindling in rats with genetic absence epilepsy
(Elsevier Inc, 2010)Two genetic models of absence epilepsy, GAERS and WAG/Rij rat strains, are resistant to progression of partial seizures induced by amygdaloid or hippocampal kindling. Perirhinal cortex is one of the crucial areas for the ... -
Perirhinal cortical kindling in rats with genetic absence epilepsy
(ELSEVIER IRELAND LTD, 2010)Two genetic models of absence epilepsy, GAERS and WAG/Rij rat strains, are resistant to progression of partial seizures induced by amygdaloid or hippocampal kindling. Perirhinal cortex is one of the crucial areas for the ... -
Prolongation of absence seizures and changes in serotonergic and dopaminergic neurotransmission by nigrostriatal pathway degeneration in genetic absence epilepsy rats
(Pergamon-Elsevier Science Ltd, 2022)Objective: Basal ganglia structures play an important role in the pathophysiology of absence epilepsy, known as remote control of absence seizures. We examined the role of the nigrostriatal dopaminergic pathway in absence ... -
The role of the substantia nigra pars reticulata in kindling resistance in rats with genetic absence epilepsy
(WILEY, 2015)ObjectiveGenetic Absence Epilepsy Rats from Strasbourg (GAERS) show a resistance to secondary generalization of focal limbic seizures evoked by kindling. The substantia nigra pars reticulata (SNR) is involved in the ...