Browsing by Author "İsbir, Turgay"
Now showing items 1-9 of 9
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Association between FAS and FASL genetic variants and risk of primary brain tumor
Dalan, Altay Burak; Timirci-Kahraman, Özlem; Turan, Saime; Kafadar, Ali Metin; Yaylım, İlhan; Ergen, Arzu; İsbir, Turgay (Informahealthcare, 2014)The purpose of this study was to investigate whether functional polymorphisms of apoptosis pathway genes FAS and FASL are associated with the development of primary brain tumors. The study constituted 83 patients with ... -
Cox-2 gene polymorphism and IL-6 levels in coronary artery disease
Ol, K.K.; Ağaçhan, Bedia; Görmüş, Uzay; Toptaş, Bahar; İsbir, Turgay (Funpec-Editora, 2011)Coronary artery disease is one of the leading causes of mortality and diabetes mellitus is one of its main risk factors due to microvascular and macrovascular complications, such as atherosclerosis. Atherosclerosis is now ... -
DNA repair based therapy in oncology and neurodegeneration
İsbir, Turgay; Görmüş, Uzay; Timirci-Kahraman, Özlem; Ergen, Arzu; Dalan, Altay Burak; Güleç-Yılmaz, Seda; Atasoy, Hande (InTech, 2015)This book edition is intended to provide a concise summary for select topics in DNA repair, a field that is ever-expanding in complexity and biologic significance. The topics reviewed ranged from fundamental mechanisms of ... -
DNA repair, cancer and cancer therapy- the current state of art
İsbir, Turgay; Demircan, Berna; Kıraç, Deniz; Dalan, Burak; Görmüş, Uzay (InTech, 2011)Over the past decades, great advances have been made in understanding the cellular DNA repair pathways. At the same time, a wealth of descriptive knowledge of human diseases has been accumulated. Now, the basic research ... -
Expression levels of elastin and related genes in human varicose veins
Görmüş, Uzay; Timirci-Kahraman, Özlem; Ergen, Arzu; Kunt, A. T.; İsbir, Selim; Dalan, A. Burak; İsbir, Turgay (2014)Among the suspected reasons for varicose vein formation are changes in the quantity and content of the elastin protein; however, comprehensive investigations about elastin assembly in varicose vein formation are yet ... -
Fas-1377 A/G polymorphism in lung cancer
Görmüş, Uzay; Ergen, Arzu; Yaylım-Eraltan, İlhan; Yılmaz, Hülya; Turna, Akif; Bozkurt, Nilüfer; İsbir, Turgay (International Institute of Anticancer Research, 2007)Background: Reduced expression of Fas and/or increased expression of FasL is known to exist in some cancer types including lung cancer, so the Fas/FasL system may play a role in the course of cancer. Lack of cell surface ... -
Fas-1377A/G and fasL-844 T/C gene polymorphisms and epithelial ovarian cancer
Görmüş, Uzay; Ergen, Arzu; Yılmaz, Hülya; Dalan, Burak; Berkman, Sinan; İsbir, Turgay (International Institute of Anticancer Research, 2007)BACKGROUND: The Fas receptor is known to be widely expressed in various tissues and FasL is highly expressed on cells of the immune system and also on cells of immune-privileged areas such as the eyes and brain. Ovarian ... -
Leptin and leptin receptor polymorphisms are related to body mass index in a Turkish population
Görmüş, Uzay; Timirci-Kahraman, Özlem; Toptaş, Bahar; İsbir, Turgay; Çiftçi, Çavlan; Berkkan, Hasan Hakan; Karatay, Mutia Canan (TUBİTAK, 2014)Background/aim: Leptin is a hormone that is known to be related to weight gain and obesity. The soluble leptin receptor has been found in plasma as an important determinant of leptin sensitivity. In this study, our goal ... -
MMP2 gene polymorphisms and MMP2 mRNA levels in patients with superficial varices of lower extremities
Görmüş, Uzay; Timirci Kahraman, Özlem; İsbir, Selim; Tekeli, Atike; İsbir, Turgay (The International Institute of Anticancer Research, 2011)Background: Although superficial varices of the lower extremities are common and with high morbidity, their etiology has not been elucidated yet. Previously, it was thought that venous hypertension was responsible for such ...