Browsing by Author "Akman, Ozlem"
Now showing items 1-12 of 12
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Agmatine has beneficial effect on harmaline-induced essential tremor in rat
Akman, Ozlem; Utkan, Tijen; Aricioglu, Feyza; Gullu, Kemal; Ates, Nurbay; Karson, Ayse (Elsevier Ireland Ltd, 2021)Essential tremor (ET) is one of the most prevalent movement disorders and the most common cause of abnormal tremors. However, it cannot be treated efficiently with the currently available pharmacotherapy options. The ... -
Atipamezole, a specific alpha(2A) antagonist, suppresses spike-and-wave discharges and alters Ca2+/calmodulin-dependent protein kinase II in the thalamus of genetic absence epilepsy rats
Objective the role of alpha(2A) adrenergic receptors (alpha(2A)ARs) in absence epilepsy is not well characterized. Therefore, we investigated the outcomes of the specific antagonism of alpha(2A)ARs on the spike-and-wave ... -
THE EFFECT OF AGMATINE ON SPIKE-AND-WAVE DISCHARGES IN A GENETIC MODEL OF ABSENCE EPILEPSY
Akman, Ozlem; Utkan, Tijen; Aricioglu, Feyza; Ates, Nurbay; Karson, Ayse (Istanbul Univ, Fac Medicine, Publ Off, 2021)Objective: Studies on the actions of exogenous agmatine in experimental models have shown its anti-convulsant effects. However, there are no findings regarding the influence of agmatine on absence epilepsy. Therefore, we ... -
The effect of chronic treatment with sodium channel blocker lacosamide on early development of absence seizures in genetic absence epilepsy rats
Carcak, Nihan; Karanfil, Ceren; Akat, Sura; Akman, Ozlem; Onat, Filiz (Elsevier, 2022)Objective: Lacosamide (LCM) is a new generation antiepileptic drug that affects the slow inactivation of voltagegated sodium channels. We studied whether chronic LCM treatment prior to onset of absence seizures was able ... -
The effect of memantine in harmaline-induced tremor and neurodegeneration
Iseri, Pervin K.; Karson, Ayse; Gullu, Kemal M.; Akman, Ozlem; Kokturk, Sibel; Yardymoglu, Melda; Ates, Nurbay (PERGAMON-ELSEVIER SCIENCE LTD, 2011)Essential tremor (ET) is one of the most common and most disabling movement disorders among adults. The drug treatment of ET remains unsatisfactory. Additional therapies are required for patients with inadequate response ... -
Electroencephalographic differences between WAG/Rij and GAERS rat models of absence epilepsy
Akman, Ozlem; Demiralp, Tamer; Ates, Nurbay; Onat, Filiz Yilmaz (ELSEVIER SCIENCE BV, 2010)The inbred Wistar Albino Glaxo Rats from Rijswijk (WAG/Rij) and the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are well-validated genetic models of absence epilepsy. Although they share similar characteristics ... -
Evaluation of GAD67 immunoreactivity in the region of substantia nigra pars reticulata in resistance to development of convulsive seizure in genetic absence epilepsy rats
Gulcebi, Medine; Akman, Ozlem; Carcak, Nihan; Karamahmutoglu, Tugba; Onat, Filiz (KARE PUBL, 2016)OBJECTIVE: Nonconvulsive absence epilepsy and convulsive epilepsy seizures are rarely seen in the same patient. It has been demonstrated that there is a resistance to development of convulsive seizures in genetic absence ... -
Perirhinal cortical kindling in rats with genetic absence epilepsy
Akman, Ozlem; Karson, Ayse; Aker, Rezzan Gulhan; Ates, Nurbay; Onat, Filiz Yilmaz (ELSEVIER IRELAND LTD, 2010)Two genetic models of absence epilepsy, GAERS and WAG/Rij rat strains, are resistant to progression of partial seizures induced by amygdaloid or hippocampal kindling. Perirhinal cortex is one of the crucial areas for the ... -
Pharmacologically induced absence seizures versus kindling in Wistar rats
Carcak, Nihan; Sahiner, Melike; Akman, Ozlem; Idrizoglu, Medine Gulcebi; Cortez, Miguel A.; Snead, O. Carter; Onat, Filiz (Kare Publ, 2020)OBJECTIVE: This study aimed to investigate the effects of gamma-butyrolactone (GBL), a prodrug of gamma-Hydroxybutyric acid-induced absence seizures on the development of kindling in Wistar rats. METHODS: Three groups of ... -
Proteome Profile of Extratemporal Structures in Amygdala Kindling Mesial Temporal Lobe Epilepsy Rat Model: A Preliminary Study
Yilmaz, Ayca Dilara; Ciftci, Gonul Gurol; Demiralp, Duygu Ozel; Igci, Nasit; Akman, Ozlem; Ates, Nurbay; Karson, Ayse (BENTHAM SCIENCE PUBL LTD, 2016)Background: Mesial temporal lobe epilepsy is the most prevalent type of human epilepsy and its pathogenesis still remains unknown. Structures outside the temporal lobe may also play critical roles in the disease's progress. ... -
The role of the substantia nigra pars reticulata in kindling resistance in rats with genetic absence epilepsy
Akman, Ozlem; Gulcebi, Medine I.; Carcak, Nihan; Ozatman, Sema Ketenci; Eryigit, Tugba; Moshe, Solomon L.; Onat, Filiz Yilmaz (WILEY, 2015)ObjectiveGenetic Absence Epilepsy Rats from Strasbourg (GAERS) show a resistance to secondary generalization of focal limbic seizures evoked by kindling. The substantia nigra pars reticulata (SNR) is involved in the ... -
Sex-specific consequences of early life seizures
Akman, Ozlem; Moshe, Solomon L.; Galanopoulou, Aristea S. (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2014)Seizures are very common in the early periods of life and are often associated with poor neurologic outcome in humans. Animal studies have provided evidence that early life seizures may disrupt neuronal differentiation and ...
