Browsing by Author "Diz-Küçükkaya, Reyhan"
Now showing items 1-17 of 17
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Acquired disorders of platelet function
Diz-Küçükkaya, Reyhan; Lopez, Jose A. (Elsevier & Saunders, 2013)Acquired disorders of platelet function are among the most common hematologic abnormalities, a reflection of the sensitivities of platelets to external and internal perturbations. The clinical challenge in evaluating ... -
ADAMTS-13 gene expression in antiphospholipid syndrome
Hançer, Veysel Sabri; Diz-Küçükkaya, Reyhan; Topal-Sarıkaya, Ayşegül (Galenos Yayınevi, 2011)Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent thrombosis and fetal mortality. Thrombotic microangiopathy (TMA) is an important histological finding in catastrophicAPS (CAPS) and in ... -
Analysis of the complement pathway mutations in atypical hemolytic uremic syndrome (AHUS)
Hançer, V. Sabri; Güvenç, Serkan; Hindilerden, Fehmi; Büyükdoğan, Murat; Diz-Küçükkaya, Reyhan (Elsevier Ltd., 2014)Background: HUS is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs. Typical HUS is triggered by infectious agents ... -
Comparison of KRAS Mutation Tests in Colorectal Cancer Patients
Hançer, Veysel Sabri; Büyükdoğan, Murat; Türkmen, İlknur; Başsüllü, Nuray; Altuğ, Tuncay; Diz-Küçükkaya, Reyhan; Demir, Osman Gökhan (2011)The KRAS pathway and studies evaluating KRAS as a prognostic marker in colorectal cancer are discussed along with advances in KRAS gene mutation testing. Highly sensitive real-time polymerase chain reaction (PCR) methods ... -
Cytotoxic T lymphocyte antigen-4 (CTLA-4) A49G polymorphism and autoimmune blood diseases
Aktürk, Faruk; Hançer, Veysel Sabri; Diz-Küçükkaya, Reyhan (Türk Hematoloji Deerneği, 2010)Objective: The cytotoxic T lymphocyte associated antigen-4 (CTLA-4) is expressed on T lymphocytes, and inhibits the T-cell responses. In animal models, it has been shown that complete CTLA-4 deficiency was lethal due to ... -
Diyaresi olan febril nötropenik hastalarda clostridium difficile toksin A ve B pozitifliği oranları ve epidemiyolojik özelliklerinin değerlendirilmesi
İris, Nur Efe; Demirel, Aslıhan; Koçulu, Safiye; Çevik, Esin; Ordu, Aylin; Diz-Küçükkaya, Reyhan (Türkiye Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Uzmanlık Derneği, 2015)Giriş: Clostridium difficile (C. difficile), antibiyotik ile ilişkili ishallerin en sık nedenidir. Özellikle immünsüpresyon önemli bir risk faktörü olduğu için diyare yakınması olan febril nötropenik hastalarda toksin A ... -
Esansiyel trombositemi ve primer miyelofibroz olgularında TET2 mutasyonu
Turan, Can (İstanbul Bilim Üniversitesi, Tıp Fakültesi., 2012)Amaç: Kronik miyeloid lösemi (KML)-dışı miyeloproliferatif neoplaziler (MPN) başlıca polistemia vera (PV), esansiyel trombositemi (ET) ve primer miyelofibroz (PMF) olarak gruplandırılır. PV eritrosit kitlesinde artış, ET ... -
Febril nötropenik hastaların kan kültürlerinden izole edilen mikroorganizmalar ve antimikrobiyal duyarlılık profili
İris, Nur Efe; Sönmez, Emine; Demirel, Aslıhan; İnan, Neşe; Arısoy, Ayşe; Çevik, Esin; Diz-Küçükkaya, Reyhan (Antibiyotik ve Kemoterapi Derneği, 2014)Febril nötropenik hastalarda başlanan ampirik antibiyotik tedavisinin uygunluğu, hastanın prognozunu belirleyen en önemli faktörlerden biridir. Bu çalışmanın amacı, febril nötropenik hastaların kan kültürlerinde üreyen ... -
Hemophagocytic syndrome associated with immune reconstitution inflammatory syndrome in a patient with AIDS related Burkitt's leukemia/lymphoma.
Kanıtez, Metin; Kapmaz, Mahir; Alpay, Nilüfer; Selcukbiricik, Fatih; Çağatay, Atahan; Diz-Küçükkaya, Reyhan (Hindawi Publishing Corporation, 2014)Highly active antiretroviral therapy (HAART) has markedly decreased human immunodeficiency virus- (HIV-) related mortality and the incidence of opportunistic infections. The dramatic reduction in HIV-1 RNA and increase in ... -
Inherited disorders of platelets membrane glycoprotein disorders
Diz-Küçükkaya, Reyhan; Lopez, Jose A. (WB Saunders, 2013)Platelet membrane glycoproteins play a key role in hemostasis and thrombosis. Although disorders of platelet membrane glycoproteins are rare, their effects on the lives of those affected are very important. Severe deficiencies ... -
Inherited platelet disorders including Glanzmann thrombasthenia and Bernard-Soulier syndrome
Diz-Küçükkaya, Reyhan (American Society of Hematology, 2013)Inherited platelet disorders (IPDs) are a heterogeneous group of diseases affecting platelet production, morphology, and function. The degree of thrombocytopenia and functional abnormality of platelets determines the ... -
Lupus anticoagulant, thrombosis, and death
Diz-Küçükkaya, Reyhan (American Society of Hematology, 2015)A 32-year-old woman was referred to the hematology clinic after she was found to have persistently positive LA tests. In such a case, 3 distinct scenarios may prompt very different responses by the hematologist. In scenario ... -
Miyeloproliferatif neoplazilerde ASXL 1 gen mutasyonlarının klinik seyir ve prognoza etkisi
Uslu, Neslihan (İstanbul Bilim Üniversitesi, Tıp Fakültesi, 2015)Amaç: Kronik miyeloproliferatif neoplaziler (MPN), kemik iliğinde her üç hücre serisinde klonal çoğalmayla karakterize hastalıklar grubunu oluşturur. Bu hastalık grubunda yer alan kronik miyeloid lösemi (KML), ‘Philedelphia ... -
MPL W515L/K mutations in chronic myeloproliferative neoplasms
Akpınar, Timur Selçuk; Hançer, Veysel Sabri; Nalçacı, Meliha; Diz-Küçükkaya, Reyhan (Galenos Yayınevi, 2013)The MPL gene encodes the thrombopoietin receptor. Recently MPL mutations (MPL W515L or MPL W515K) were described in patients with essential thrombocythemia (ET) and primary (idiopathic) myelofibrosis (PMF). The prevalence ... -
Nadir görülen bir trombositopeni nedeni: Siklik trombositopeni
Kurt, Burcu; Altun, Yağız Meriç; Güvenç, Serkan; Uslu, Neslihan; Diz-Küçükkaya, Reyhan (İstanbul Bilim Üniversitesi, Tıp Fakültesi, 2016)Siklik trombositopeni (STP), trombosit sayısında periyodik olarak dalgalanma ile seyreden, tipik olarak trombositopeniyi takip eden rebound trombositoz ile karakterize, nadir görülen bir hastalıktır. İmmün trombositopeni ... -
Quinolone resistance of gram negative bacteria from the patients with malignancies and relationship with prophylaxis
Fluoroquinolones are the most commonly used antibiotics for the treatment and prophylaxis of patients with malignancies. But resistance development is a big problem.With the aim of identifying the epidemiological data about ... -
The relationship between P-Selectin polymorphisms and thrombosis in antiphospholipid syndrome: A pilot case-control study
Alpay, Nilüfer; Hançer, Veysel Sabri; Erer, Burak; İnanç, Murat; Diz-Küçükkaya, Reyhan (Galenos Yayınevi, 2014)Objective: The selectins are cell adhesion molecules that mediate the interactions among leukocytes, activated platelets, and endothelial cells. We aimed to investigate whether P-selectin polymorphisms are associated with ...
