Browsing by Author "Erbas, Oytun"

Accumulation of alpha-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers

Solmaz, Volkan; Ozlece, Hatice Kose; Eroglu, Huseyin Avni; Aktug, Huseyin; Erbas, Oytun; Taskiran, Dilek (HINDAWI PUBLISHING CORP, 2017)

Objective. The present study was conducted to evaluate the relationship between plasma oxidative stress markers such as malondialdehyde (MDA) and glutathione (GSH), inflammatory marker pentraxin-3 (PTX3), and cerebellar ...

The Ameliorative Effects of Ascorbic Acid on Critical Illness Polyneuropathy in Rodent Sepsis Model

Sunnetci Silistre, Eda; Erbas, Oytun (Georg Thieme Verlag Kg, 2020)

Although the exact pathophysiology of critical illness polyneuropathy (CIP) is still unknown, there are several hypotheses, some of which are increased inflammation and oxidative stress. We used rodent sepsis model in which ...

Antifibrotic Effect of Lactulose on a Methotrexate-Induced Liver Injury Model

Taskin, Banu; Erdogan, Mumin Alper; Yigitturk, Gurkan; Gunenc, Damla; Erbas, Oytun (HINDAWI LTD, 2017)

The most severe side effect of prolonged MTX treatment is hepatotoxicity. The aim of this study is to investigate the effect of lactulose treatment on MTX-induced hepatotoxicity in a rat model. Twenty-four male rats were ...

Antifibrotic preventive effect of polyethylene glycol (PEG) 3350 in methotrexate-induced hepatoxicity model

Acar, Huseyin; Sorgun, Omay; Yurtseve, Guner; Bora, Ejder Saylav; Erbas, Oytun (Acta Cirurgica Brasileira, 2022)

Purpose: Liver damage caused by drugs and other chemicals accounts for about 5% of all cases. Methotrexate (MTX), a folic acid analogue, is a first-line synthetic antimetabolite agent routinely used in the treatment of ...

The antioxidant role of agomelatine and gallic acid on oxidative stress in STZ induced type I diabetic rat testes

Yigitturk, Gurkan; Acara, Ahmet Cagdas; Erbas, Oytun; Oltulu, Fatih; Yavasoglu, Nefise Ulku Karabay; Uysal, Aysegul; Yavasoglu, Altug (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017)

Diabetes is a multisystem disorder and its effects are observed on the reproductive system. One of the main causes of testicular tissue damage is diabetes-induced overproduction of reactive oxygen species and glycated end ...

Antipsychotic Like Effects of Atorvastatin and Melatonin in a Psychosis Model in Rats

Solmaz, Volkan; Delibas, Dursun Hakan; Inanir, Sema; Erbas, Oytun (YERKURE TANITIM & YAYINCILIK HIZMETLERI A S, 2015)

Objective: In recent years besides dopaminergic imbalance exhibition of other possible mechanisms like inflammation and serotonergic abnormalities have pointed out the need for new antipsychotic drugs. In this study our ...

Atorvastatin has therapeutic potential for the fatty liver-induced memory dysfunction in rats, likely via its antioxidant and anti-inflammatory properties

Solmaz, Volkan; Atasoy, Ozum; Erbas, Oytun (Taylor & Francis Ltd, 2020)

This study aimed to evaluate the memory function in a rat model of fatty liver and to investigate the effects of statins on fatty liver, neuronal inflammation, oxidative stress and memory. in this study, 24 male rats were ...

Beneficial effects of agomelatine in experimental model of sepsis-related acute kidney injury

Basol, Nursah; Erbas, Oytun; Cavusoglu, Turker; Meral, Ayfer; Ates, Utku (TURKISH ASSOC TRAUMA EMERGENCY SURGERY, 2016)

BACKGROUND: Sepsis-related acute kidney injury (AKI) is a serious complication of sepsis. Problems persist regarding early diagnosis and treatment of AKI. The aim of the present study was to evaluate the efficacy of ...

Beneficial Effects of Ibuprofen on Pentylenetetrazol-induced Convulsion

Durankus, Ferit; Senkal, Evrim; Sunnetci, Eda; Albayrak, Yakup; Beyazyuz, Murat; Atasoy, Ozum; Erbas, Oytun (Springer/Plenum Publishers, 2020)

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used as an anti-inflammatory, anti-pyretic, and analgesic. Although some studies have focused on the anti-inflammatory and anti-pyretic properties ...

Comparison of the Effects of Extracorporeal Irradiation and Liquid Nitrogen on Nerve Recovery in a Rat Model

Kaya, Huseyin; Sabah, Dundar; Kececi, Burcin; Kucuk, Levent; Erbas, Oytun; Oltulu, Fatih; Taskiran, Dilek

Aim of the study: Biologic reconstruction using tumor-bearing bone autografts devitalized by liquid nitrogen or extracorporeal irradiation (oncological sterilization) is a safe and effective method in musculoskeletal ...

Demonstration of ameliorating effect of vardenafil through its anti-inflammatory and neuroprotective properties in autism spectrum disorder induced by propionic acid on rat model

Ozkul, Bahattin; Urfali, Furkan Erturk; Sever, Ibrahim Halil; Bozkurt, Mehmet Fatih; Sogut, Ibrahim; Elgormus, Cagri Serdar; Erbas, Oytun (Taylor & Francis Ltd, 2022)

Introduction Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex etiology. In this study, we aimed to determine the ameliorating effects of vardenafil in the ASD rat model induced by propionic acid ...

Dexpanthenol reduces fibrosis and aids repair following nerve laceration and neurorrhaphy

Karahan, Gokhan; Kaya, Huseyin; Eyceyurt, Recep Selcuk; Erdogan, Mumin Alper; Yigitturk, Gurkan; Erbas, Oytun (Spandidos Publ Ltd, 2021)

The aim of the present study was to investigate the effect of dexpanthenol on nerve healing following neurorrhaphy in lacerated peripheral nerves. A total of 30 mature Sprague Dawley rats were used. Surgical sciatic nerve ...

The diagnostic utility of scintigraphy in esophageal burn: a rat model

Ciftci, Oznur Dilek; Gul, Serdar Savas; Aciksari, Kurtulus; Maman, Adem; Cavusoglu, Turker; Bademci, Refik; Erbas, Oytun (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2016)

Background: Corrosive esophageal injury due to accidental ingestion is a serious clinical problem in children particularly in developing countries. The present study was conducted to evaluate the diagnostic utility of ...

Digoxin Exhibits Neuroprotective Properties in a Rat Model of Dementia

Erdogan, Mumin Alper; Kirazlar, Mehmet; Yigitturk, Gurkan; Erbas, Oytun (Springer/Plenum Publishers, 2021)

Alzheimer's disease (AD) is by far the most common cause of cognitive impairment in older adults. Current treatments are entirely focused on the symptoms of AD. A complex etiology for AD has been proposed recently, in which ...

Effect of Lipid Emulsion on the Improvement of Renal Damage in Colist-in-Induced Nephrotoxicity

Senkal, Naci; Atasoy, Ozum; Caparali, Emine Bilge; Erdogan, Mumin Alper; Erbas, Oytun (Bentham Science Publ, 2021)

Background: Colistin utilization has gradually increased worldwide with the rising of multidrug-resistant (MDR) gram-negative bacilli despite its nephrotoxicity. Lipid emulsion (LE) is widely used for the toxic overdose ...

The effect of Madopar on absence-like seizures in WAG/Rij rats

Al-Kaleel, Ali; Erbas, Oytun; Aygun, Hatice (Nencki Inst Experimental Biology, 2022)

The aim of this study was to investigate the effect of Madopar on the absence seizures and the anxiety-like behavior (assessed using the open field test) in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. Twenty-eight male ...

Effect of platelet-rich plasma on reconstruction with nerve autografts

Teymur, Hakan; Tiftikcioglu, Yigit Ozer; Cavusoglu, Turker; Tiftikcioglu, Bedile Irem; Erbas, Oytun; Yigitturk, Gurkan; Uyanikgil, Yigit (ELSEVIER TAIWAN, 2017)

Despite advances in understanding of peripheral nerve injuries and regeneration and advances in surgical techniques, successful outcomes cannot be guaranteed after reconstructive surgery. Platelet-rich plasma (PRP) has ...

The effects of diltiazem and metoprolol in QTc prolongation due to amitriptyline intoxication

Basol, Nursah; Erbas, Oytun (SAGE PUBLICATIONS LTD, 2016)

Background and objective: Amitriptyline, a frequently used tricyclic antidepressant agent, has powerful cardiotoxic effects especially in high doses. Serum and urine levels of amitriptyline dosages are not correlated with ...

The Effects of Lipid Emulsion, Magnesium Sulphate and Metoprolol in Amitriptyline-Induced Cardiovascular Toxicity in Rats

Bora, Saylav; Erdogan, Mumin Alper; Yigitturk, Gurkan; Erbas, Oytun; Parlak, Ismet (HUMANA PRESS INC, 2018)

The aim of this study was to evaluate the effects of metoprolol, lipid emulsion and MgSO4 which can be recommended for prevention of long QT that is one of the lethal consequences of amitriptyline intoxication. Thirty ...

Effects of Methylene Blue on Ovarian Torsion - Detorsion Injury in a Rat Model

Ilgen, Orkun; Hortu, Ismet; Ozceltik, Gokay; Yigitturk, Gurkan; Erbas, Oytun; Karadadas, Nedim (Elsevier Science Inc, 2020)

Study Objectives