Browsing by Author "Erbas, Oytun"
Now showing items 1-20 of 62
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Accumulation of alpha-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers
Solmaz, Volkan; Ozlece, Hatice Kose; Eroglu, Huseyin Avni; Aktug, Huseyin; Erbas, Oytun; Taskiran, Dilek (HINDAWI PUBLISHING CORP, 2017)Objective. The present study was conducted to evaluate the relationship between plasma oxidative stress markers such as malondialdehyde (MDA) and glutathione (GSH), inflammatory marker pentraxin-3 (PTX3), and cerebellar ... -
The Ameliorative Effects of Ascorbic Acid on Critical Illness Polyneuropathy in Rodent Sepsis Model
Sunnetci Silistre, Eda; Erbas, Oytun (Georg Thieme Verlag Kg, 2020)Although the exact pathophysiology of critical illness polyneuropathy (CIP) is still unknown, there are several hypotheses, some of which are increased inflammation and oxidative stress. We used rodent sepsis model in which ... -
Antifibrotic Effect of Lactulose on a Methotrexate-Induced Liver Injury Model
Taskin, Banu; Erdogan, Mumin Alper; Yigitturk, Gurkan; Gunenc, Damla; Erbas, Oytun (HINDAWI LTD, 2017)The most severe side effect of prolonged MTX treatment is hepatotoxicity. The aim of this study is to investigate the effect of lactulose treatment on MTX-induced hepatotoxicity in a rat model. Twenty-four male rats were ... -
Antipsychotic Like Effects of Atorvastatin and Melatonin in a Psychosis Model in Rats
Solmaz, Volkan; Delibas, Dursun Hakan; Inanir, Sema; Erbas, Oytun (YERKURE TANITIM & YAYINCILIK HIZMETLERI A S, 2015)Objective: In recent years besides dopaminergic imbalance exhibition of other possible mechanisms like inflammation and serotonergic abnormalities have pointed out the need for new antipsychotic drugs. In this study our ... -
Antipsychotic-Like Effect of Agomelatine in a Rodent Model
Erbas, Oytun; Elikucuk, Betul; Solmaz, Volkan; Akseki, Huseyin Serdar; Semiz, Murat (YERKURE TANITIM & YAYINCILIK HIZMETLERI A S, 2015)Antipsychotic-like effect of agomelatine in a rodent model Objective: Agomelatine is a naphthalene bioisostere of melatonin. Melatonin is involved in several neurophysiological systems; nevertheless, data about the ... -
Atorvastatin has therapeutic potential for the fatty liver-induced memory dysfunction in rats, likely via its antioxidant and anti-inflammatory properties
Solmaz, Volkan; Atasoy, Ozum; Erbas, Oytun (Taylor & Francis Ltd, 2020)This study aimed to evaluate the memory function in a rat model of fatty liver and to investigate the effects of statins on fatty liver, neuronal inflammation, oxidative stress and memory. in this study, 24 male rats were ... -
Beneficial effects of agomelatine in experimental model of sepsis-related acute kidney injury
Basol, Nursah; Erbas, Oytun; Cavusoglu, Turker; Meral, Ayfer; Ates, Utku (TURKISH ASSOC TRAUMA EMERGENCY SURGERY, 2016)BACKGROUND: Sepsis-related acute kidney injury (AKI) is a serious complication of sepsis. Problems persist regarding early diagnosis and treatment of AKI. The aim of the present study was to evaluate the efficacy of ... -
Beneficial Effects of Ibuprofen on Pentylenetetrazol-induced Convulsion
Durankus, Ferit; Senkal, Evrim; Sunnetci, Eda; Albayrak, Yakup; Beyazyuz, Murat; Atasoy, Ozum; Erbas, Oytun (Springer/Plenum Publishers, 2020)Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used as an anti-inflammatory, anti-pyretic, and analgesic. Although some studies have focused on the anti-inflammatory and anti-pyretic properties ... -
Comparison of the Effects of Extracorporeal Irradiation and Liquid Nitrogen on Nerve Recovery in a Rat Model
Kaya, Huseyin; Sabah, Dundar; Kececi, Burcin; Kucuk, Levent; Erbas, Oytun; Oltulu, Fatih; Taskiran, DilekAim of the study: Biologic reconstruction using tumor-bearing bone autografts devitalized by liquid nitrogen or extracorporeal irradiation (oncological sterilization) is a safe and effective method in musculoskeletal ... -
Effect of platelet-rich plasma on reconstruction with nerve autografts
Teymur, Hakan; Tiftikcioglu, Yigit Ozer; Cavusoglu, Turker; Tiftikcioglu, Bedile Irem; Erbas, Oytun; Yigitturk, Gurkan; Uyanikgil, Yigit (ELSEVIER TAIWAN, 2017)Despite advances in understanding of peripheral nerve injuries and regeneration and advances in surgical techniques, successful outcomes cannot be guaranteed after reconstructive surgery. Platelet-rich plasma (PRP) has ... -
Effects of Methylene Blue on Ovarian Torsion - Detorsion Injury in a Rat Model
Ilgen, Orkun; Hortu, Ismet; Ozceltik, Gokay; Yigitturk, Gurkan; Erbas, Oytun; Karadadas, Nedim (Elsevier Science Inc, 2020)Study Objectives -
Erythropoietin shows gender dependent positive effects on social deficits, learning/memory impairments, neuronal loss and neuroinflammation in the lipopolysaccharide induced rat model of autism
Solmaz, Volkan; Erdogan, Mumin Alper; Alnak, Alper; Meral, Ayfer; Erbas, Oytun (Churchill Livingstone, 2020)We aimed to evaluate the effects of EPO in the lipopolysaccharide (LPS) induced rat model of autism in terms of social deficits, learning and memory impairments, as well as their neurochemical correlates. Sixteen female ... -
Evaluation of long-term effects of artificial sweeteners on rat brain: a biochemical, behavioral, and histological study
Erbas, Oytun; Erdogan, Mumin Alper; Khalilnezhad, Asghar; Solmaz, Volkan; Gurkan, Fulya Tuzcu; Yigitturk, Gurkan; Taskiran, Dilek (WILEY, 2018)The aim of the present study was to compare the effects of artificial sweeteners (aspartame, saccharin, and sucralose) on rat brain. Twenty-four adult male Sprague-Dawley rats were included in the study. The control group ... -
Exenatide preserves trabecular bone microarchitecture in experimental ovariectomized rat model
Eminov, Elmin; Hortu, Ismet; Akman, Levent; Erbas, Oytun; Yavasoglu, Altug; Cirpan, Teksin (SPRINGER HEIDELBERG, 2018)Purpose The aim of this study is to investigate effects of exenatide (Glucagon-Like Peptide Agonist) replacement on bone mineral density (BMD) and microarchitecture in a surgical menopause-induced osteoporosis model in ... -
Exenatide reduces TNF-alpha expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats
Solmaz, Volkan; Cinar, Bilge Piri; Yigitturk, Gurkan; Cavusoglu, Turker; Taskiran, Dilek; Erbas, Oytun (ELSEVIER SCIENCE BV, 2015)Recent studies suggest a possible link between type 2 diabetes and Alzheimer's disease (AD). Glucoganlike peptide 1 (GLP-1) facilitates insulin release from pancreas under hyperglycemic conditions. In addition to its ... -
Exenatide, a GLP-1 analog, has healing effects on LPS-induced autism model: Inflammation, oxidative stress, gliosis, cerebral GABA, and serotonin interactions
Solmaz, Volkan; Tekatas, Aslan; Erdogan, Mumin Alper; Erbas, Oytun (Wiley, 2020)Previous studies have established anti-inflammatory, antioxidant, and neuroprotective effects of Exenatide in the central nervous system. Since these mechanisms are thought to have important roles in the pathophysiology ... -
Exogenously administered adenosine attenuates renal damage in streptozotocin-induced diabetic rats
Taskiran, Emin; Erbas, Oytun; Yigitturk, Gurkan; Meral, Ayfer; Akar, Harun; Taskiran, Dilek (TAYLOR & FRANCIS LTD, 2016)Background: Diabetic nephropathy (DNP) is one of the most serious complications of diabetes mellitus (DM). In the present study, we investigated the potential of adenosine as a therapeutic candidate for preventing DNP.Methods: ... -
Granulocyte colony-stimulating factor provides protection against cardiovascular autonomic neuropathy in streptozotocin-induced diabetes in rats
Erbas, Oytun; Solmaz, Volkan; Taskiran, Dilek (ELSEVIER IRELAND LTD, 2015)Aims: Cardiovascular autonomic neuropathy (CAN) is a relatively common and detrimental complication of diabetes mellitus (DM). Dysregulation of neuropeptides, such as calcitonin gene-related peptide (CGRP) and vasoactive ... -
Güçlü antikosidan kurkuminin sisplatinin neden olduğu karaciğer ve böbrek hasarında önemli etkileri
Amaç: Sisplatin (CIS) sıklıkla kullanılan oldukça güçlü bir anti kanser ajandır. Sisplatinin toksik etkileri kullanımını sınırlandırmaktadır. Sunulan bu deneysel çalışmada, sisplatinin nefrotoksik ve hepatotoksik yan ... -
Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy
Erdogan, Mumin Alper; Yusuf, Dimas; Christy, Joanna; Solmaz, Volkan; Erdogan, Arife; Taskiran, Emin; Erbas, Oytun (BIOMED CENTRAL LTD, 2018)Background: Worldwide, over 10 million individuals suffer from drug-resistant epilepsy. New therapeutic strategies are needed to address this debilitating disease. Inhibition of sodium-glucose linked transporters (SGLTs), ...
