Browsing by Author "Erdogan, Mumin Alper"
Now showing items 1-13 of 13
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Antifibrotic Effect of Lactulose on a Methotrexate-Induced Liver Injury Model
Taskin, Banu; Erdogan, Mumin Alper; Yigitturk, Gurkan; Gunenc, Damla; Erbas, Oytun (HINDAWI LTD, 2017)The most severe side effect of prolonged MTX treatment is hepatotoxicity. The aim of this study is to investigate the effect of lactulose treatment on MTX-induced hepatotoxicity in a rat model. Twenty-four male rats were ... -
Erythropoietin shows gender dependent positive effects on social deficits, learning/memory impairments, neuronal loss and neuroinflammation in the lipopolysaccharide induced rat model of autism
Solmaz, Volkan; Erdogan, Mumin Alper; Alnak, Alper; Meral, Ayfer; Erbas, Oytun (Churchill Livingstone, 2020)We aimed to evaluate the effects of EPO in the lipopolysaccharide (LPS) induced rat model of autism in terms of social deficits, learning and memory impairments, as well as their neurochemical correlates. Sixteen female ... -
Evaluation of long-term effects of artificial sweeteners on rat brain: a biochemical, behavioral, and histological study
Erbas, Oytun; Erdogan, Mumin Alper; Khalilnezhad, Asghar; Solmaz, Volkan; Gurkan, Fulya Tuzcu; Yigitturk, Gurkan; Taskiran, Dilek (WILEY, 2018)The aim of the present study was to compare the effects of artificial sweeteners (aspartame, saccharin, and sucralose) on rat brain. Twenty-four adult male Sprague-Dawley rats were included in the study. The control group ... -
Exenatide, a GLP-1 analog, has healing effects on LPS-induced autism model: Inflammation, oxidative stress, gliosis, cerebral GABA, and serotonin interactions
Solmaz, Volkan; Tekatas, Aslan; Erdogan, Mumin Alper; Erbas, Oytun (Wiley, 2020)Previous studies have established anti-inflammatory, antioxidant, and neuroprotective effects of Exenatide in the central nervous system. Since these mechanisms are thought to have important roles in the pathophysiology ... -
Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy
Erdogan, Mumin Alper; Yusuf, Dimas; Christy, Joanna; Solmaz, Volkan; Erdogan, Arife; Taskiran, Emin; Erbas, Oytun (BIOMED CENTRAL LTD, 2018)Background: Worldwide, over 10 million individuals suffer from drug-resistant epilepsy. New therapeutic strategies are needed to address this debilitating disease. Inhibition of sodium-glucose linked transporters (SGLTs), ... -
Levodropropizine suppresses seizure activity in rats with pentylenetetrazol-induced epilepsy
Erdogan, Mumin Alper; Yusuf, Dimas; Erdogan, Arife; Erbas, Oytun (ELSEVIER SCIENCE BV, 2019)Background: Millions of individuals worldwide suffer from epilepsy, and up to 25% of patients have seizures that are resistant to currently available antiepileptic drugs. Hence, there continues to be a need for more seizure ... -
Neurobehavioral effects of long-term maternal fructose intake in rat offspring
Erbas, Oytun; Erdogan, Mumin Alper; Khalilnezhad, Asghar; Gurkan, Fulya Tuzcu; Yigitturk, Gurkan; Meral, Ayfer; Taskiran, Dilek (PERGAMON-ELSEVIER SCIENCE LTD, 2018)Background: Previous studies have indicated an association between maternal metabolic conditions and general developmental disturbances of the offspring. Objective: We aimed to investigate the influence of long-term maternal ... -
The potential effects of anticonvulsant drugs on neuropeptides and neurotrophins in pentylenetetrazol kindled seizures in the rat
Tekgul, Hasan; Simsek, Erdem; Erdogan, Mumin Alper; Yigitturk, Gurkan; Erbas, Oytun; Taskiran, Dilek (Taylor & Francis Ltd, 2020)Purpose: Neuropeptides and neurotrophic factors are thought to be involved in epileptogenesis. This study aims to investigate the potential effects of anticonvulsant drugs on neuropeptides (galanin and neuropeptide Y) and ... -
The Protective Effects of Carvedilol on Diabetic Nephropathy in A Streptozotocin-Induced Diabetic Rat Model
Erdogan, Mumin Alper; Yigitturk, Gurkan; Erbas, Oytun (Wiley, 2019)[No abstract available] -
The reducing effect of agomelatine on pentylenetetrazol-induced convulsions
Demirel, Esra Aciman; Erdogan, Mumin Alper; Cinar, Bilge Piri; Erbas, Oytun (Akademiai Kiado Zrt, 2019)Introduction: Agomelatine is a potent MT1 and MT2 melatonin receptor agonist and a 5-HT2C serotonin receptor antagonist. the purpose of this study was to show the convulsion-reducing effect of agomelatine, in both clinical ... -
The Effects of Lipid Emulsion, Magnesium Sulphate and Metoprolol in Amitriptyline-Induced Cardiovascular Toxicity in Rats
Bora, Saylav; Erdogan, Mumin Alper; Yigitturk, Gurkan; Erbas, Oytun; Parlak, Ismet (HUMANA PRESS INC, 2018)The aim of this study was to evaluate the effects of metoprolol, lipid emulsion and MgSO4 which can be recommended for prevention of long QT that is one of the lethal consequences of amitriptyline intoxication. Thirty ... -
Therapeutic effects of vitamin D on acetic acid-induced colitis in rats
Bademci, Refik; Erdogan, Mumin Alper; Kara, Ali Yucel; Yigitturk, Gurkan; Erbas, Oytun (Acta Cirurgica Brasileira, 2020)Purpose: To analyze the effect of calcitriol treatment on acute colitis in an experimental rat model. Methods: A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups: control group (n:8), ...
