Browsing by Author "Ozkul, Bahattin"
Now showing items 1-12 of 12
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Ameliorating Effect of Propofol on Cisplatin -Induced Liver and Kidney Damage in Rats
Ozkul, Ozlem; Ozkul, Bahattin; Erdogan, Mumin Alper; Erbas, Oytun (Asian Network Scientific Information-Ansinet, 2022)Background and Objective: Cisplatin is among the most frequently used in solid organ cancers. However, it can be dose-limiting, especially due to its side effects on the kidney and liver. This study aims to examine the ... -
Atorvastatin Improves the Propionic Acid- Induced Autism in Rats: The Roles of Sphingosine-1-Phosphate and Anti-inflammatory Action
Durankus, Ferit; Budak, Korkut; Albayrak, Yakup; Sever, Ibrahim H.; Ozkul, Bahattin; Uyanikgil, Yigit; Albayrak, Neslihan (Cureus Inc, 2023)Purpose The aim of this study is to investigate the benefits of atorvastatin on the propionic acid-induced autism model via increasing sphingosine-1-phosphate and anti-inflammatory actions with imaging and brain tissue ... -
Demonstration of ameliorating effect of vardenafil through its anti-inflammatory and neuroprotective properties in autism spectrum disorder induced by propionic acid on rat model
Ozkul, Bahattin; Urfali, Furkan Erturk; Sever, Ibrahim Halil; Bozkurt, Mehmet Fatih; Sogut, Ibrahim; Elgormus, Cagri Serdar; Erbas, Oytun (Taylor & Francis Ltd, 2022)Introduction Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex etiology. In this study, we aimed to determine the ameliorating effects of vardenafil in the ASD rat model induced by propionic acid ... -
Evaluation of Chest CT Findings using the Reporting and Data System of Patients with Suspected COVID-19 Infection
Sever, Ibrahim Halil; Ozkul, Bahattin; Sokmen, Bedriye Koyuncu; Gurcan, Nagihan Ivan (Zamensalamati Publ Co, 2021)Background: The simultaneous interpretation of computed tomography (CT) scans performed on patients with suspected clinical signs of coronavirus disease 2019 (COVID-19) or a history of contact may accelerate patient ... -
Modafinil Improves Autism-like Behavior in Rats by Reducing Neuroinflammation
Bagcioglu, Erman; Solmaz, Volkan; Erbas, Oytun; Ozkul, Bahattin; Cakar, Burak; Uyanikgil, Yigit; Sogut, Ibrahim (Springer, 2023)To evaluate the ameliorating effect of Modafinil on neuroinflammation, behavioral, and histopathological alterations in rats induced by propionic acid (PPA). Thirty male Wistar rats were used in the study, divided into 3 ... -
Prenatal SARS-CoV-2 Spike Protein Exposure Induces Autism-Like Neurobehavioral Changes in Male Neonatal Rats
Erdogan, Mumin Alper; Turk, Miray; Doganay, Gizem Dinler; Sever, Ibrahim Halil; Ozkul, Bahattin; Sogut, Ibrahim; Eroglu, Ebru (Springer, 2023)Recent research on placental, embryo, and brain organoids suggests that the COVID-19 virus may potentially affect embryonic organs, including the brain. Given the established link between SARS-CoV-2 spike protein and ... -
Protective Effects of Ibudilast Against Cisplatin-Induced Hepatotoxicity and Nephrotoxicity Mediated by Prostacyclin Enhancement
Ozkul, Ozlem; Ozkul, Bahattin; Erdogan, Mumin Alper; Erbas, Oytun (Asian Network Scientific Information-Ansinet, 2023)Background and Objective: Cisplatin, a prevalent chemotherapy drug, presents hepatotoxic and nephrotoxic side effects, this study explores ibudilast's potential protective effects against such damage via prostacyclin ... -
Reparative, Neuroprotective and Anti-Neurodegenerative Effects of Granulocyte Colony Stimulating Factor in Radiation-Induced Brain Injury Model
Gurkan, Goekhan; Atasoy, Ozum; Cini, Nilsu; Sever, Ibrahim Halil; Ozkul, Bahattin; Yaprak, Gokhan; Sirin, Cansin (Korean Neurosurgical Soc, 2023)Objective : This animal model aimed to compare the rat group that received brain irradiation and did not receive additional treatment (only saline) and the rat group that underwent brain irradiation and received Granulocyte ... -
Repeated gadoteric acid and gadobutrol exposure causes deterioration of behavior and memory functions in rats: MRI, histopathological and biochemical evidence
Solmaz, Volkan; Ozlece, Hatice Kose; Bozkurt, Mehmet Fatih; Ozkul, Bahattin; Erbas, Oytun (Elsevier, 2021)Gadolinium-based contrast agents (GBCAs) exert effects in different regions of the brain; however, studies on this topic are mostly focused on radiological outcomes of GBCA exposure. This paper is a preliminary attempt to ... -
Short term protective effect of digitoxin in sepsis-induced acute lung injury
Bora, Ejder Saylav; Erdogan, MuMIN Alper; Ozkul, Bahattin; Sever, Ibrahim Halil; Sogut, Ibrahim; Hurdag, Canan; Erbas, Oytun (Tech Science Press, 2022)Purpose: Digitoxin is a cardiac glycoside used in the treatment of heart failure. Inspired by its known antiinflammatory effect, this study aims to investigate the effect of digoxin in a sepsis model and to bring to light ... -
Short term protective effect of digitoxin in sepsis-induced acute lung injury
Bora, Ejder Saylav; Erdogan, MuMIN Alper; Ozkul, Bahattin; Sever, Ibrahim Halil; Sogut, Ibrahim; Hurdag, Canan; Erbas, Oytun (Tech Science Press, 2022)Purpose: Digitoxin is a cardiac glycoside used in the treatment of heart failure. Inspired by its known antiinflammatory effect, this study aims to investigate the effect of digoxin in a sepsis model and to bring to light ...
