Browsing by Author "Sogut, Ibrahim"
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Anti-Inflammatory Effects of Melatonin in Rats with Induced Type 2 Diabetes Mellitus
Yapislar, Hande; Haciosmanoglu, Ebru; Sarioglu, Turkan; Degirmencioglu, Sevgin; Sogut, Ibrahim; Poteser, Michael; Ekmekcioglu, Cem (Mdpi, 2022)Introduction: Insulin resistance is associated with a pro-inflammatory state increasing the risk for complications in patients with type 2 diabetes mellitus (T2DM). In addition to its chronobiotic effects, the pineal hormone ... -
The antioxidant and antiapoptotic effect of boric acid on hepatoxicity in chronic alcohol-fed rats
Sogut, Ibrahim; Paltun, Sila Ozlem; Tuncdemir, Matem; Ersoz, Melike; Hurdag, Canan (CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS, 2018)The harmful use of alcohol is a worldwide problem involving all ages. This study aims to investigate chronic alcohol exposure related hepatotoxicity on the rat liver and possible hepatoprotective effects of boric acid. ... -
Biological assays on the effects of Acra3 peptide from Turkish scorpion Androctonus crassicauda venom on a mouse brain tumor cell line (BC3H1) and production of specific monoclonal antibodies
Caliskan, Figen; Ergene, Emel; Sogut, Ibrahim; Hatipoglu, Ibrahim; Basalp, Aynur; Sivas, Hulya; Kanbak, Gungor (PERGAMON-ELSEVIER SCIENCE LTD, 2013)Constitutes of the venom scorpion are a rich source of low molecular mass peptides which are toxic to various organisms, including man. Androctonus crassicauda is one of the scorpions from the Southeastern Anatolia of ... -
The Comparative Effects of Inulin and Bacillus clausii on LPS-Induced Endotoxemic Rat Liver
Sogut, Ibrahim; Kar, Fatih; Tanrikulu-Kucuk, Sevda; Gozden, Tarik Talha; Can, Sumeyye Asena; Kandil, Asli (Taylor & Francis Inc, 2022)Background This paper sought to investigate the modifies of inulin and Bacillus clausii on the lipopolysaccharides (LPS) inducing oxidative stress signaling pathway in the endotoxemic rat model. Methods Wistar albino male ... -
Demonstration of ameliorating effect of vardenafil through its anti-inflammatory and neuroprotective properties in autism spectrum disorder induced by propionic acid on rat model
Ozkul, Bahattin; Urfali, Furkan Erturk; Sever, Ibrahim Halil; Bozkurt, Mehmet Fatih; Sogut, Ibrahim; Elgormus, Cagri Serdar; Erbas, Oytun (Taylor & Francis Ltd, 2022)Introduction Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex etiology. In this study, we aimed to determine the ameliorating effects of vardenafil in the ASD rat model induced by propionic acid ... -
Dietary curcumin and capsaicin: Relationship with hepatic oxidative stress and apoptosis in rats fed a high fat diet
Tannkulu-Kucuk, Sevda; Basaran-Kucukgergin, Canan; Sogut, Ibrahim; Tuncdemir, Matem; Dogru-Abbasoglu, Semra; Seyithanoglu, Muhammed; Oner-Iyidogan, Yidiz (Wroclaw Medical Univ, 2019)Background. Apoptosis plays a major role in fatty liver disease. High-fat diets are related to the onset of fatty liver disease and hepatic oxidant-antioxidant imbalance. Curcumin and capsaicin are somewhat beneficial in ... -
Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome
Sogut, Ibrahim; Oglakci, Aysegul; Kartkaya, Kazim; Ol, Kevser Kusat; Sogut, Melis Savasan; Kanbak, Gungor; Inal, Mine Erden (SPANDIDOS PUBL LTD, 2015)To the best of our knowledge, this is the first study concerning the effect of boric acid (BA) administration on fetal alcohol syndrome (FAS). In this study, the aim was to investigate prenatal alcohol-induced oxidative ... -
Effect of chronic alcohol consumption on myocardial apoptosis in the rat model of isoproterenol-induced myocardial injury and investigation on the cardioprotective role of calpain inhibitor 1
Oglakci-Ilhan, Aysegul; Kusat-Ol, Kevser; Uzuner, Kubilay; Uysal, Onur; Sogut, Ibrahim; Yucel, Ferruh; Kanbak, Gungor (Taylor & Francis Ltd, 2021)We investigated the presence of myocardial apoptosis on isoproterenol (ISO)-induced myocardial injury (MI) after long-term high dose alcohol consumption and examined the antiapoptotic role of calpain inhibitor 1. Male ... -
Effect of fulvic acid on gastric mucosa damage caused by chronic water avoidance stress
Gurel, Sezen Gizem; Sogut, Ibrahim; Hurdag, Canan; Gurel, Ali; Tutar, Ahmet; Cikler-Dulger, Esra (Taylor & Francis Ltd, 2021)We investigated the antioxidant and anti-ulcerogenic effects of fulvic acid (FA) on oxidative damage caused by water avoidance stress (WAS) in rat gastrointestinal mucosa. Three experimental groups were established: control ... -
The Effects of Fulvic Acid Against Water Avoidance Stress- Induced Damage of Rat Colon Mucosa
Cikler, Esra; Sogut, Ibrahim; Aydogan, Sezen Gizem; Kirmizikan, Seda; Hurdag, Canan (Marmara Univ, Inst Health Sciences, 2023)Objective: Chronic stress plays an important role in the etiology of many inflammatory diseases. Reactive oxygen species (ROS), a source of free radicals, act as signaling molecules in the progression of stress-related ... -
Erythrocytic Reduced/Oxidized Glutathione and Serum Thiol/Disulfide Homeostasis in Patients with Opioid Use Disorder
Sahin, Esra Kabadayi; Senat, Almila; Sogut, Ibrahim; Duymaz, Tomris; Erel, Ozcan (Aves, 2023)Background: This study aimed to evaluate oxidative damage by measuring erythrocytic reduced/oxidized glutathione as an intracellular thiol pool and serum thiol/disulfide homeostasis as an extracellular thiol pool in patients ... -
Evaluation of Atherosclerotic Risk by Oxidative Contributors in Alcohol Use Disorder
Senat, Almila; Kabadayi-Sahin, Esra; Sogut, Ibrahim; Duymaz, Tomris; Erel, Ozcan (Korean Coll Neuropsychopharmacology, 2023)Objective: Alcohol Use Disorder (AUD) is a condition described as the inability to control or stop alcohol consumption. The patients with AUD have an increased risk of developing atherosclerosis-related diseases. The present ... -
Evaluation of Oxidative Stress and Thiol-Disulfide Parameters According to the Body Mass Index in Adult Individuals
Sogut, Ibrahim; Aydin, Almila Senat; Gokmen, Emel Saglam; Atak, Palmet Gun; Erel, Ozcan; DeGrigo, Uzay Gormus (AVES, 2018)Objective: In this study, the parameters of oxidative stress markers and thiol-disulfide homeostasis as a novel biomarker were evaluated in experimental groups of adult individuals, which were formed according to the body ... -
Evaluation of Thiol/Disulfide Homeostasis and Other Oxidative Stress Markers in Patients Undergoing Hemodialysis
Sogut, Ibrahim; Senat, Almila; Ilhan, Aysegul Oglakci; Sezen, Adem; Erel, Ozcan (Aves, 2021)Objective: To investigate the potential role of thiol/disulphide homeostasis as a novel biomarker of oxidative stress in patients with diabetes and undergoing hemodialysis (HD) and its correlation with other oxidative ... -
In Vivo Assessment of the Effect of Hexagonal Boron Nitride Nanoparticles on Biochemical, Histopathological, Oxidant and Antioxidant Status
Kar, Fatih; Hacioglu, Ceyhan; Goncu, Yapincak; Sogut, Ibrahim; Senturk, Hakan; Donmez, Dilek Burukoglu; Ay, NuranThe aim of our study is to investigate the dose-dependent biological system effect of hexagonal boron nitride (hBN) nanoparticles, which is directly produced nanoscale, in vivo. Wistar albino rats (n = 80) weighing 200-250 ... -
An Investigation into the Protective Effects of Various Doses of Boric Acid on Liver, Kidney, and Brain Tissue Damage Caused by High Levels of Acute Alcohol Consumption
Ilhan, Aysegul Oglakci; Can, Betul; Kar, Fatih; Gundogdu, Ayse Cakir; Sogut, Ibrahim; Kanbak, Gungor (Springernature, 2023)Acute high-dose alcohol consumption can lead to oxidative stress, which can cause harm to organs. In this study we aim to determine whether administering boric acid (BA) can protect certain organs (liver, kidney, and brain) ... -
Modafinil Improves Autism-like Behavior in Rats by Reducing Neuroinflammation
Bagcioglu, Erman; Solmaz, Volkan; Erbas, Oytun; Ozkul, Bahattin; Cakar, Burak; Uyanikgil, Yigit; Sogut, Ibrahim (Springer, 2023)To evaluate the ameliorating effect of Modafinil on neuroinflammation, behavioral, and histopathological alterations in rats induced by propionic acid (PPA). Thirty male Wistar rats were used in the study, divided into 3 ... -
Prenatal alcohol-induced neuroapoptosis in rat brain cerebral cortex: protective effect of folic acid and betaine
Sogut, Ibrahim; Uysal, Onur; Oglakci, Aysegul; Yucel, Ferruh; Kartkaya, Kazim; Kanbak, Gungor (SPRINGER, 2017)Purpose Alcohol consumption in pregnancy may cause fetal alcohol syndrome (FAS) in the infant. This study aims to investigate prenatal alcohol exposure related neuroapoptosis on the cerebral cortex tissues of newborn rats ... -
Prenatal SARS-CoV-2 Spike Protein Exposure Induces Autism-Like Neurobehavioral Changes in Male Neonatal Rats
Erdogan, Mumin Alper; Turk, Miray; Doganay, Gizem Dinler; Sever, Ibrahim Halil; Ozkul, Bahattin; Sogut, Ibrahim; Eroglu, Ebru (Springer, 2023)Recent research on placental, embryo, and brain organoids suggests that the COVID-19 virus may potentially affect embryonic organs, including the brain. Given the established link between SARS-CoV-2 spike protein and ...
