Browsing by Author "Yigitturk, Gurkan"
Now showing items 1-20 of 37
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Antifibrotic Effect of Lactulose on a Methotrexate-Induced Liver Injury Model
Taskin, Banu; Erdogan, Mumin Alper; Yigitturk, Gurkan; Gunenc, Damla; Erbas, Oytun (HINDAWI LTD, 2017)The most severe side effect of prolonged MTX treatment is hepatotoxicity. The aim of this study is to investigate the effect of lactulose treatment on MTX-induced hepatotoxicity in a rat model. Twenty-four male rats were ... -
The antioxidant role of agomelatine and gallic acid on oxidative stress in STZ induced type I diabetic rat testes
Yigitturk, Gurkan; Acara, Ahmet Cagdas; Erbas, Oytun; Oltulu, Fatih; Yavasoglu, Nefise Ulku Karabay; Uysal, Aysegul; Yavasoglu, Altug (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017)Diabetes is a multisystem disorder and its effects are observed on the reproductive system. One of the main causes of testicular tissue damage is diabetes-induced overproduction of reactive oxygen species and glycated end ... -
Dexpanthenol reduces fibrosis and aids repair following nerve laceration and neurorrhaphy
Karahan, Gokhan; Kaya, Huseyin; Eyceyurt, Recep Selcuk; Erdogan, Mumin Alper; Yigitturk, Gurkan; Erbas, Oytun (Spandidos Publ Ltd, 2021)The aim of the present study was to investigate the effect of dexpanthenol on nerve healing following neurorrhaphy in lacerated peripheral nerves. A total of 30 mature Sprague Dawley rats were used. Surgical sciatic nerve ... -
Digoxin Exhibits Neuroprotective Properties in a Rat Model of Dementia
Erdogan, Mumin Alper; Kirazlar, Mehmet; Yigitturk, Gurkan; Erbas, Oytun (Springer/Plenum Publishers, 2021)Alzheimer's disease (AD) is by far the most common cause of cognitive impairment in older adults. Current treatments are entirely focused on the symptoms of AD. A complex etiology for AD has been proposed recently, in which ... -
Digoxin Exhibits Neuroprotective Properties in a Rat Model of Dementia
Erdogan, Mumin Alper; Kirazlar, Mehmet; Yigitturk, Gurkan; Erbas, Oytun (Springer/Plenum Publishers, 2022)Alzheimer's disease (AD) is by far the most common cause of cognitive impairment in older adults. Current treatments are entirely focused on the symptoms of AD. A complex etiology for AD has been proposed recently, in which ... -
Effect of platelet-rich plasma on reconstruction with nerve autografts
Teymur, Hakan; Tiftikcioglu, Yigit Ozer; Cavusoglu, Turker; Tiftikcioglu, Bedile Irem; Erbas, Oytun; Yigitturk, Gurkan; Uyanikgil, Yigit (ELSEVIER TAIWAN, 2017)Despite advances in understanding of peripheral nerve injuries and regeneration and advances in surgical techniques, successful outcomes cannot be guaranteed after reconstructive surgery. Platelet-rich plasma (PRP) has ... -
The Effects of Lipid Emulsion, Magnesium Sulphate and Metoprolol in Amitriptyline-Induced Cardiovascular Toxicity in Rats
Bora, Saylav; Erdogan, Mumin Alper; Yigitturk, Gurkan; Erbas, Oytun; Parlak, Ismet (HUMANA PRESS INC, 2018)The aim of this study was to evaluate the effects of metoprolol, lipid emulsion and MgSO4 which can be recommended for prevention of long QT that is one of the lethal consequences of amitriptyline intoxication. Thirty ... -
Effects of Methylene Blue on Ovarian Torsion - Detorsion Injury in a Rat Model
Ilgen, Orkun; Hortu, Ismet; Ozceltik, Gokay; Yigitturk, Gurkan; Erbas, Oytun; Karadadas, Nedim (Elsevier Science Inc, 2020)Study Objectives -
The efficacy of Aesculus hippocastanum seeds on diabetic nephropathy in a streptozotocin-induced diabetic rat model
Elmas, Onur; Erbas, Oytun; Yigitturk, Gurkan (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2016)Cytokines, such as transforming growth factor (TGF)-beta 1, and increased oxidative stress are considered to be responsible for the development of diabetic nephropathy. We hypothesized that Aesculus hippocastanum (AH) seeds ... -
Evaluation of long-term effects of artificial sweeteners on rat brain: a biochemical, behavioral, and histological study
Erbas, Oytun; Erdogan, Mumin Alper; Khalilnezhad, Asghar; Solmaz, Volkan; Gurkan, Fulya Tuzcu; Yigitturk, Gurkan; Taskiran, Dilek (WILEY, 2018)The aim of the present study was to compare the effects of artificial sweeteners (aspartame, saccharin, and sucralose) on rat brain. Twenty-four adult male Sprague-Dawley rats were included in the study. The control group ... -
Exenatide reduces TNF-alpha expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats
Solmaz, Volkan; Cinar, Bilge Piri; Yigitturk, Gurkan; Cavusoglu, Turker; Taskiran, Dilek; Erbas, Oytun (ELSEVIER SCIENCE BV, 2015)Recent studies suggest a possible link between type 2 diabetes and Alzheimer's disease (AD). Glucoganlike peptide 1 (GLP-1) facilitates insulin release from pancreas under hyperglycemic conditions. In addition to its ... -
Exogenously administered adenosine attenuates renal damage in streptozotocin-induced diabetic rats
Taskiran, Emin; Erbas, Oytun; Yigitturk, Gurkan; Meral, Ayfer; Akar, Harun; Taskiran, Dilek (TAYLOR & FRANCIS LTD, 2016)Background: Diabetic nephropathy (DNP) is one of the most serious complications of diabetes mellitus (DM). In the present study, we investigated the potential of adenosine as a therapeutic candidate for preventing DNP.Methods: ... -
An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment
Taskin, Banu; Erdogan, Mumin Alper; Yigitturk, Gurkan; Alper, Sibel; Erbas, Oytun (Hindawi Ltd, 2021)Purpose. The aim of the study is to examine the possible therapeutic effects of a known cardiac glycoside, digoxin, on a rat model of MTX-induced hepatotoxicity. Methods. The study was conducted on twenty-four male rats. ... -
The Healing Effect of Digoxin on Peripheral Nerve Damage and Its Relation to IL-17/IL-10
Gurkan, Gokhan; Erdogan, Mumin Alper; Karahan, Gokhan; Kaya, Huseyin; Yigitturk, Gurkan; Kizmazoglu, Ceren; Erbas, Oytun (Turkish Neurosurgical Soc, 2023)AIM: To demonstrate the curative effect of digoxin on peripheral nerve damage with its anti-inflammatory role on interleukin (IL)-17. MATERIAL and METHODS: The study was conducted with 30 male Sprague Dawley albino mature ... -
How Safe is the Use of Intrathecal Fluorescein? An Experimental Study
Camlar, Mahmut; Turk, Caglar; Oltulu, Fatih; Oren, Merve; Buhur, Aylin; Yigitturk, Gurkan; Gazioglu, Nurperi (TURKISH NEUROSURGICAL SOC, 2019)AIM: To investigate the effects of fluorescein-sodium on neural tissues. MATERIAL and METHODS: Twenty-one Wistar rats were randomly divided into three experimental groups: control (group 1) and fluorescein-sodium groups ... -
The investigation of therapeutic potential of oxytocin and liraglutide on vincristine-induced neuropathy in rats
Erdogan, Mumin A.; Taskiran, Emin; Yigitturk, Gurkan; Erbas, Oytun; Taskiran, Dilek (Wiley, 2020)The aim of this study was to assess the therapeutic potential of oxytocin and liraglutide (LIR), a GLP-1 analogue, in a rat model of vincristine-induced neuropathy. Rats were injected with vincristine (VCR) at a dose of 4 ... -
Losartan ameliorates ovarian ischaemia/reperfusion injury in rats: an experimental study
Hortu, Ismet; Ilgen, Orkun; Sahin, Cagdas; Akdemir, Ali; Yigitturk, Gurkan; Erbas, Oytun (Taylor & Francis Inc, 2020)This study aimed to investigate the protective and antioxidant role of losartan in ovarian ischaemia and ischaemia/reperfusion injury in an experimental ovarian torsion model. Thirty adult female rats were used. Rats were ... -
NEPHROPROTECTIVE EFFECT OF ADENOSINE IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Taskiran, Emin; Erbas, Oytun; Yigitturk, Gurkan; Taskiran, Dilek; Akar, Harun (OXFORD UNIV PRESS, 2016)… -
The neuro-restorative effect of adipose-derived mesenchymal stem cell transplantation on a mouse model of diabetic neuropathy
Yigitturk, Gurkan; Erbas, Oytun; Karabay Yavasoglu, Nefise Ulku; Acikgoz, Eda; Buhur, Aylin; Gokhan, Aylin; Gurel, Cevik (Taylor & Francis Ltd, 2021)Diabetic neuropathy (DN) is the most common degenerative complication associated with Diabetes Mellitus. Despite widespread awareness about DN, the only effective treatments are blood glucose control and pain management. ...
