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Therapeutic effect of sunitinib on diabetes mellitus related ovarian injury: an experimental rat model study
(INFORMA HEALTHCARE, 2015)
The aim of our study is to investigate the effect of sunitinib on diabetes mellitus related-ovarian injury and fibrosis in rat models. An experimental diabetes mellitus model was created in 16 rats, and eight rats with ...
Accumulation of alpha-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers
(HINDAWI PUBLISHING CORP, 2017)
Objective. The present study was conducted to evaluate the relationship between plasma oxidative stress markers such as malondialdehyde (MDA) and glutathione (GSH), inflammatory marker pentraxin-3 (PTX3), and cerebellar ...
Neurobehavioral effects of long-term maternal fructose intake in rat offspring
(PERGAMON-ELSEVIER SCIENCE LTD, 2018)
Background: Previous studies have indicated an association between maternal metabolic conditions and general developmental disturbances of the offspring. Objective: We aimed to investigate the influence of long-term maternal ...
Octreotide protects ovary against ischemia-reperfusion injury in rats: Evaluation of histological and biochemical parameters
(WILEY-BLACKWELL, 2015)
AimThis study investigated the efficacy of octreotide for prevention of ischemia-reperfusion injury in rat ovary. MethodsThirty-two adult female rats were included. Rats were divided into five groups: in the sham group, ...
The effects of diltiazem and metoprolol in QTc prolongation due to amitriptyline intoxication
(SAGE PUBLICATIONS LTD, 2016)
Background and objective: Amitriptyline, a frequently used tricyclic antidepressant agent, has powerful cardiotoxic effects especially in high doses. Serum and urine levels of amitriptyline dosages are not correlated with ...
Granulocyte colony-stimulating factor provides protection against cardiovascular autonomic neuropathy in streptozotocin-induced diabetes in rats
(ELSEVIER IRELAND LTD, 2015)
Aims: Cardiovascular autonomic neuropathy (CAN) is a relatively common and detrimental complication of diabetes mellitus (DM). Dysregulation of neuropeptides, such as calcitonin gene-related peptide (CGRP) and vasoactive ...
The antioxidant role of agomelatine and gallic acid on oxidative stress in STZ induced type I diabetic rat testes
(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017)
Diabetes is a multisystem disorder and its effects are observed on the reproductive system. One of the main causes of testicular tissue damage is diabetes-induced overproduction of reactive oxygen species and glycated end ...
Neuroprotective effects of erythropoietin on Alzheimer's dementia model in rats
(WROCLAW MEDICAL UNIV, 2017)
Background. Although Alzheimer's disease (AD) is the most common age-related neurodegenerative disease and characterized by memory impairment, only symptomatic treatments are available. Objectives. Because recombinant human ...
Neuroprotective effects of chronic administration of levetiracetam in a rat model of diabetic neuropathy
(ELSEVIER IRELAND LTD, 2016)
Objective: Diabetic neuropathy (DNP) is a frequent and serious complication of diabetes mellitus (DM) that leads to progressive and length-dependent loss of peripheral nerve axons. The purpose of the present study is to ...
Levodropropizine suppresses seizure activity in rats with pentylenetetrazol-induced epilepsy
(ELSEVIER SCIENCE BV, 2019)
Background: Millions of individuals worldwide suffer from epilepsy, and up to 25% of patients have seizures that are resistant to currently available antiepileptic drugs. Hence, there continues to be a need for more seizure ...