Fen Edebiyat Fakültesi Makaleleri Koleksiyonunu içerir http://hdl.handle.net/11446/247 2026-04-18T09:29:46Z 2026-04-18T09:29:46Z Krespi Boothby, Margörit Rita Hill, Jonathan Holcombe, Christopher Clark, Louise Fisher, Jean Salmon, Peter http://hdl.handle.net/11446/1211 2020-11-15T12:33:19Z 2010-01-01T00:00:00Z

HAD ve GSA-12?nin meme kanseri hastalarında psikiyatrik hastalanmayı belirlemedeki gücü Krespi Boothby, Margörit Rita; Hill, Jonathan; Holcombe, Christopher; Clark, Louise; Fisher, Jean; Salmon, Peter Amaç: Doktor ve hemşirelerin, meme kanseri hastalarına hastalığın getirdiği güçlüklerle başa çıkabilmelerinde yardım edebilmeleri için, bu hastalardaki psikolojik problemlerin ileriye yönelik (proaktif) olarak belirlenmesi gerekmektedir. Duygusal problemlerin ileriye yönelik olarak belirlenmesi için olası bir yol taramadır. Kaynakların sınırlılığı nedeniyle çok sayıda hasta ile görüşme yapmak güç olduğundan, tarama sırasında psikiyatrik görüşmeler yerine kendini bildirim ölçeklerinden yararlanmak faydalı olabilir. Bu tür iki ölçek: Hastane Anksiyete ve Depresyon (HAD) ölçeği ve Genel Sağlık Anketi-12?dir (GSA-12).; Objective: Psychological problems should be identified in breast cancer patients proactively if doctors and nurses are to help them cope with the challenges imposed by their illness. Screening is one possible way to identify emotional problems proactively. Self-report questionnaires can be useful alternatives to carrying out psychiatric interviews during screening, because interviewing a large number of patients can be impractical due to limited resources. Two such measures are the Hospital Anxiety and Depression Scale (HADS) and the General Health Questionnaire-12 (GHQ-12). İstanbul Bilim Üniversitesi, Fen Edebiyat Fakültesi

2010-01-01T00:00:00Z Coşkun, Zeynep Mine Bolkent, Sema http://hdl.handle.net/11446/993 2020-11-15T12:29:19Z 2016-01-01T00:00:00Z

Evaluation of Δ(9)-tetrahydrocannabinol metabolites and oxidative stress in type 2 diabetic rats. Coşkun, Zeynep Mine; Bolkent, Sema Objectives: The object of the study is to examine the effects of Δ9-tetrahydrocannabinol (THC) against oxidative stress in the blood and excretion of THC metabolites in urine of type 2 diabetic rats. Materials and Methods: The control (n=8), THC control (n=6), diabetes (n=8) and diabetes + THC (n=7) groups were created. Type 2 diabetes was induced by nicotinamide (NA, 85 mg/kg) + streptozotocin (STZ, 65 mg/kg). THC was administered intraperitoneally for seven days. The glutathione (GSH) level in erythrocytes and malondialdehyde (MDA) level, superoxide dismutase (SOD) and catalase (CAT) enzyme activities in plasma were measured. THC metabolites were analyzed in urine. İstanbul Bilim Üniversitesi, Fen Edebiyat Fakültesi.

2016-01-01T00:00:00Z Coşkun, Zeynep Mine Bolkent, Sema http://hdl.handle.net/11446/761 2021-06-10T13:22:27Z 2014-01-01T00:00:00Z

Oxidative stress and cannabinoid receptor expression in type-2 diabetic rat pancreas following treatment with Δ9-THC Coşkun, Zeynep Mine; Bolkent, Sema The objectives of study were (a) to determine alteration of feeding, glucose level and oxidative stress and (b) to investigate expression and localization of cannabinoid receptors in type-2 diabetic rat pancreas treated with Δ9-tetrahydrocannabinol (Δ9-THC). Rats were randomly divided into four groups: control, Δ9-THC, diabetes and diabetes + Δ9-THC groups. Diabetic rats were treated with a single dose of nicotinamide (85 mg/kg) 15 min before injection of streptozotocin (65 mg/kg). Δ9-THC was administered intraperitoneally at 3 mg/kg/day for 7 days. Body weights and blood glucose level of rats in all groups were measured on days 0, 7, 14 and 21. On day 15 after the Δ9-THC injections, pancreatic tissues were removed. Blood glucose levels and body weights of diabetic rats treated with Δ9-THC did not show statistically significant changes when compared with the diabetic animals on days 7, 14 and 21. Treatment with Δ9-THC significantly increased pancreas glutathione levels, enzyme activities of superoxide dismutase and catalase in diabetes compared with non-treatment diabetes group. The cannabinoid 1 receptor was found in islets, whereas the cannabinoid 2 receptor was found in pancreatic ducts. Their localization in cells was both nuclear and cytoplasmic. We can suggest that Δ9-THC may be an important agent for the treatment of oxidative damages induced by diabetes. However, it must be supported with anti-hyperglycaemic agents. Furthermore, the present study for the first time emphasizes that Δ9-THC may improve pancreatic cells via cannabinoid receptors in diabetes. İstanbul Bilim Üniversitesi, Fen Edebiyat Fakültesi.

2014-01-01T00:00:00Z