http://hdl.handle.net/11446/1325 TR-Dizin Indexed Publications Collection 2026-04-16T20:27:10Z http://hdl.handle.net/11446/5445 The effects of herbal cream and silymarin on liver in carbon tetrachloride-treated animals Kandil, Asli; Kilic, Aysu; Gurel Gurevin, Ebru; Sogut, Ibrahim; Ustunova, Savas; Eren, Seyma; Caner, Metin Many medical or pharmaceutical plants have been widely used for the treatment of the liver injury. Silymarin is now used as a food-supporting material for the liver as a patented product. Herbal cream has antiinflammatory and antioxidant effects on wound healing in a hemorrhoid model. This study aimed to evaluate the effects of herbal cream and silymarin on the liver in carbon tetrachloride (CCl4)-treated animals. Male Wistar rats were divided into seven groups as Intact control, Control, Herbal cream (0.5 ml, intrarectal), Silymarin (70 mg/kg, intrarectal), CCl4 (2 ml/kg, intraperitoneal), CCl4+Herbal cream (0.5 ml herbal cream for 21 days, 3 weeks after administration of CCl4) and CCl4+Silymarin (70 mg/kg silymarin for 21 days, 3 weeks after administration of CCl4). Herbal cream reduced damage and leukocyte distribution induced by CCl4 and increased catalase. There was no significant change in superoxide dismutase (SOD) and glutathione peroxidase (GPx). The levels of SOD, catalase, and GPx in the liver increased significantly in the group treated only with herbal cream. These results point out that herbal cream may have antioxidant properties in the liver and a role in preventing liver damage. As a result, it has been detected that herbal cream is not a toxic agent and recovers liver damage with antioxidant properties. 2025-01-01T00:00:00Z http://hdl.handle.net/11446/5433 Association of Different Doses of Curcumin with Preadipocyte to Adipocyte Differentiation Cetinalp, Pinar; Değirmencioğlu, Sevgin; Tanrikulu Küçük, Sevda; Seyithanoǧlu, Muhammed; Öner-Iyidoǧan, Yildiz; Koçak, Hikmet Objective: Human adipose tissue participates in fat storage and immune response. Curcumin (CUR) decreases adipocyte differentiation by inhibiting inflammatory cytokines and by activating anti-inflammatory cytokines. In this study, we aimed to determine the suppressor effects of different doses of CUR (0.5 µM, 5 µM, 10 µM, 20 µM, 50 µM) on preadipocyte-adipocyte differentiation and its anti-inflammatory role in adipocytes. Methods: Differentiation of cells was performed using Oil Red O. The mRNA expression levels of adiponectin, C/EBPα, COX-2, IL-6, leptin, NFκB1, PPARγ, SIRT-1, TNF-α, TRPV1, UCP2, VEGF-A, VEGF-RI, and VEGF-RII were evaluated in preadipocyte and adipocytes. Results: CUR decreased the differentiation of preadipocytes-adipocytes and the release of proinflammatory cytokines by regulating the expression of C/EBPα and PPARγ gene expressions. Conclusion: CUR inhibited adipogenic transcription factors and adipocyte differentiation at all concentrations. The anti-inflammatory effect was greatest at 50 µM. © 2025 Elsevier B.V., All rights reserved. 2025-01-01T00:00:00Z http://hdl.handle.net/11446/5418 Lowering propionic acid levels by regulating gut microbiota with ursodeoxycholic acid appears to regress autism symptoms: an animal study Karkaş, Levent; Solmaz, Volkan; Bağcıoğlu, Erman; Özkul, Bahattin; Söğüt, İbrahim; Uyanikgil, Yiğit; Erbai, Oytun Aims: Patients with autism have altered gut microbiata, including higher frequency of bacteroidetes and clostridiales that produce of propionic acid (PPA) –a compound that is established as an autism-inducing agent. We hypothesized that lowering the PPA levels by regulating gut microbiata with ursodeoxycholic acid (UDCA) can regress the autism symptoms. The aim of this study is to examine the potential ameliorating effects of UDCA on a PPA-induced rat model of autism. Methods: Thirty male Wistar albino rats were divided into three groups: controls, PPA-induced (5 days of intraperitoneal 250 mg/kg/day dosage) autism model receiving oral saline, and PPA-induced autism model receiving oral UDCA (100 mg/kg/day). Oral treatments were applied for 15 days. At the end of the 15th day, all rats underwent behavioral tests and MR spectroscopy. At the end of the study, all animals were sacrificed and brain tissue / blood samples were collected for histopathological and biochemical analyses. Results: Sociability test, open field test and passive avoidance learning tests were impaired, similar to the autism behavioral pattern, in PPA recipients; however, results were closer to normal patterns in the PPA+UDCA group. Biochemically, MDA, TNF-alpha, IL-2, IL-17, NF-kB, lactate, NGF and NRF2 levels in brain tissues showed significant differences between controls and the PPA+Saline group, and between the PPA+Saline group and the PPA+UDCA group (p< 0.05, for all). Histopathology showed that PPA injection caused increased glial activity, neural body degeneration, decreased neural count and dysmorphic changes in hippocampal and cerebellar tissues (p<0.01, for all). UDCA treatment significantly ameliorated these changes. Conclusion: UDCA administration has ameliorating effects on PPA-induced autism-like behavioral, biochemical and histopathological changes in rats. 2023-01-01T00:00:00Z http://hdl.handle.net/11446/5419 SAĞLIK BİLİMLERİ ÖĞRENCİLERİNİN NOMOFOBİ DÜZEYLERİNİN BELİRLENMESİNE YÖNELİK BİR ÖLÇEK GELİŞTİRME ÇALIŞMASI Kabul, Enes; Temizer, Ali Mesut; Karagöz, Yalçın Bu çalışmanın temel amacı, akıllı telefon bağımlılığının ileri aşaması olan nomofobi ölçeğinin geliştirilmesidir. Çalışmanın alt amacı olarak ise farklılık analizleri yapılmıştır. Çalışma nicel araştırma yöntemi temel alınarak yürütülmüştür. Bu doğrultuda Bolu ve İstanbul’da eğitimine devam eden 395 üniversite öğrencisine 22 maddelik ölçek formu uygulanmıştır. Katılımcılardan elde edilen veriler SPSS ve AMOS programlarından yararlanılarak değerlendirilmiştir. Açıklayıcı faktör analizi sonucunda oluşturulan 22 maddelik ölçeğin 3 boyutlu (Negatif Etki, Endişe ve Duygusal Bağ) bir yapıya sahip olduğu görülmüştür. Daha sonra yapısal eşitlik modellemesi yardımıyla doğrulayıcı faktör analizi yapılmış, elde edilen uyum indeksi değerlerinin iyi uyum gösterdikleri belirlenerek model uyumunun sağlandığı görülmüştür. Sonuç olarak geliştirilen nomofobi ölçeğinin geçerli ve güvenilir bir ölçek olduğu görülmüştür. 2025-01-01T00:00:00Z