PubMed İndeksli Yayınlar Koleksiyonu
http://hdl.handle.net/11446/3523
PubMed Indexed Publications Collection
2024-03-29T05:05:58Z
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Effects of Long-term Administration of Inhaled Lavender During Hemodialysis on Patients’ Invasive Pain, Anxiety, and Comfort During Cannulation: A Single-blind Randomized Controlled Trial
http://hdl.handle.net/11446/4914
Effects of Long-term Administration of Inhaled Lavender During Hemodialysis on Patients’ Invasive Pain, Anxiety, and Comfort During Cannulation: A Single-blind Randomized Controlled Trial
Ozen N.; Sayilan A.A.; Ok E.; Sayilan S.; Ozen V.; Sousa C.N.; Ovayolu O.
Context • Although a number of studies have shown that lavender administered via inhalation can decrease the invasive pain and anxiety experienced by hemodialysis (HD) patients during cannulation, the evaluation has mostly been on the short-term effectiveness of lavender oil. Also, no study has evaluated the effects of lavender on comfort level. Objective • The study aimed to investigate the long-term effectiveness of lavender oil, when administered via an inhaler during HD sessions, on a patient’s experience of invasive pain, anxiety, and comfort during access to the fistula. Design • The research team designed a prospective, single-blind, randomized, controlled clinical trial. Setting • The study took place in an HD unit of a public hospital in Kirklareli, Turkey. Participants • Participants were 24 patients receiving HD in the unit between January and March 2021. Intervention • Participants were randomly assigned to the intervention or control group. Pure lavender essence was diluted with sweet almond oil at a ratio of 1:10. Before the cannulation procedure at 12 HD sessions, three drops of a 1:10 mixture were placed on sterile gauze and held at a distance of about 10 cm from the participant’s nose to ensure its inhalation before the fistula puncture with the needle. No extra procedure was performed for the control group. Outcome Measures • Participants completed a visual analogue scale (VAS) right after puncture of the fistula during each HD session. The STAI and HD Comfort Scale were scored at baseline prior to the first HD session and postintervention at the twelfth HD session. Results • The VAS (P <.001) and state anxiety scores (P =.027) were significantly lower in the intervention group than in the control group at all time points, except at baseline. The comfort scale in the intervention group was significantly higher than that in the control group (P <.05) Conclusions • Lavender aromatherapy could be a good option for reducing the pain, anxiety, and discomfort level of HD patients. © 2023, InnoVision Communications. All rights reserved.
2023-01-01T00:00:00Z
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Evaluation of Resting-State Functional Magnetic Resonance Imaging Findings of Patients with Social Anxiety Disorder
http://hdl.handle.net/11446/4907
Evaluation of Resting-State Functional Magnetic Resonance Imaging Findings of Patients with Social Anxiety Disorder
Ergül C.; Yildiz Ç.U.; Kurt E.; Kiçİk A.; Tükel R.
Objective: The most prominent functional magnetic resonance imaging findings of social anxiety disorder are increased activity in emotional regulation areas (amygdala, insula, hippocampus, dorsal anterior cingulate cortex) and fear circuit and altered activity in the prefrontal cortex. This study aims to investigate network abnormalities during resting state. Method: Resting-state functional magnetic resonance images of 21 drug-free patients with social anxiety disorder and 21 healthy controls (matched according to age, gender, and years of education) were recorded. Resting-state functional connectivity networks were obtained with independent component analysis and were compared by using the voxel-based t-test between the two groups. Results: Patients with social anxiety disorder displayed decreased intrinsic functional connectivity in the anterior component of the salience network (left orbitofrontal cortex) and increased intrinsic functional connectivity in the posterior component of the salience network (left supramarginal gyrus). Conclusion: Most of the studies about social anxiety disorder mainly focused on the fear circuit and emotional regulation areas by using anxietyprovoking tasks or by using seed-based analysis of functional connectivity. By applying a whole-brain independent component analysis, we found altered functional connectivity in the salience network, but no significant difference was found in the fear circuit areas. Our results suggest that abnormal connectivity in the salience network might play a crucial role in the neurobiology of social anxiety disorder. © 2022,Turk Psikiyatri Dergisi.All Rights Reserved
2022-01-01T00:00:00Z
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Investigation of Neuroprotective Effect of Shilajit Extract in Experimental Head Trauma Model Created in Rats
http://hdl.handle.net/11446/4908
Investigation of Neuroprotective Effect of Shilajit Extract in Experimental Head Trauma Model Created in Rats
Karaoglu A.C.; Atci I.B.; Demirel N.; Turk O.; Hurdag C.; Baran O.; Ozdemir N.G.
AIM: To investigate the neuroprotective effect of shilajit extract in experimental head trauma. MATERIAL and METHODS: Three groups of 33 Sprague Dawley Albino strain male rats were included in the study. Group 1 (n=11): trauma but not treated. Group 2 (n=11): trauma and treated with 0.5 mL / rat saline Group 3 (n=11): 150 mg / kg shilajit extract was administered intraperitoneally in the treatment of trauma. Following the head trauma, the indicated treatments were applied to the 2nd and 3rd groups at the first, twenty-four and forty-eighth hours. Brain tissues and blood samples were taken after the control animals were sacrificed at the 72nd hour in all groups after trauma. Sections prepared from cerebral cortex and ca1 region were examined with hematoxylin eosin and luxol fast blue staining. Total antioxidant capacity, total oxidant capacity and oxidative stress index were measured from blood samples taken after routine procedures. RESULTS: The number of red neurons and the severity of edema were significantly higher in both the cerebral cortex and the ca1 region in the group treated with trauma only and in the group administered saline after trauma compared to the group that received shilajit extract after trauma. The total antioxidant capacity increased significantly in blood samples taken only from the group treated with trauma and saline in post-trauma treatment compared to the group given post-traumatic shilajit extract, while shilajit extract given due to traumatic brain injury significantly decreased the total oxidant capacity and oxidative stress index values compared to the other groups. CONCLUSION: Shilajit extract has been shown to have a neuroprotective effect in the treatment of acute traumatic brain injury. Our study showed that shilajit may be a useful option in the treatment of secondary brain injury, in humans. © (2023), (Turkish Neurosurgical Society). All Rights Reserved.
2023-01-01T00:00:00Z
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Effect of Voltage-Gated Sodium Channel Inhibitors on the Metastatic Behavior of Prostate Cancer Cells: A Meta-Analysis
http://hdl.handle.net/11446/4900
Effect of Voltage-Gated Sodium Channel Inhibitors on the Metastatic Behavior of Prostate Cancer Cells: A Meta-Analysis
Yildirim-Kahriman S.
Background and Objective: Functional Voltage-Gated Sodium Channels (VGSCs) are expressed in metastatic prostate cancer (PCa) cells. A number of in vitro studies have evaluated the effect of functional VGSC expression on the metastatic cell behavior of PCa cells. This study aimed to evaluate the effect of VGSC inhibition on metastatic cell behavior in PCa cells by meta-analysis. Materials and Methods: Meta-analysis was performed on data taken from 13 publications that examined the effect of VGSC inhibitors on the metastatic cell behavior of metastatic PCa cells expressing functional VGSCs. The measure of effect was calculated according to the random effects model using mean differences and presented with a forest plot graph. Heterogeneity was checked using the Cochran’s Q Test (Chi-square statistic) and the I2 test statistic. In order to evaluate the objectivity, the funnels-plot graph was used. Results: The g value showing the effect size was calculated as 4.49 (95% CI = 5.35-3.62) in the experiments where Tetrodotoxin (TTX) was used, which has a very high specificity for VGSCs but is not licensed for clinical use. In experiments using licensed inhibitors Lamotrigine, Oxcarbazepine, Phenytoin, Ranolazine, Riluzole and Lidocaine, the g value was 1.37 (95 % CI = 2.02-0.71). Suppression of metastatic cell behavior in both subgroups is statistically significant (p<0.00001). Conclusion: Meta-analysis confirmed that VGSCs are an enhancing factor in the metastasis of PCa cells. The VGSCs appear to be an important target in the diagnosis and development of new treatment options in PCa. © 2023 Senay Yildirim-Kahriman.
2023-01-01T00:00:00Z