Demiroglu Bilim Universitesi
http://acikerisim.demiroglu.bilim.edu.tr:8080/xmlui
DSpace dijital arşiv sistemi toplar, depolar, dizinler, korur ve dijital araştırma materyallerini dağıtmaya aracılık eder.2024-03-29T07:46:39ZTriglyceride-Glucose Index Could be Used to Predict Severity of Coronary Artery Ectasia
http://hdl.handle.net/11446/4945
Triglyceride-Glucose Index Could be Used to Predict Severity of Coronary Artery Ectasia
Oflar, Ersan; Yıldız, Cennet; Bostancı, Gungor Ilayda; Mavi, Büşra; Turhan, Nihan; Sahin, Alparslan; Ungan, İsmail
Introduction: Coronary artery ectasia (CAE) refers to a 1.5 fold increase in coronary artery diameter compared to the normal segment. Although the underlying pathophysiological mechanism is not fully elucidated, coronary atherosclerosis is thought to play a role in more than half of the cases. Triglyceride glucose (TyG) index is an indicator of insulin resistance. In the present study, aimed to evaluated TyG index values in CAE cases and find if a predictive value of TyG index existed. Patients and Methods: Sixty-one patients with CAE (study group) and 64 patients with normal coronary arteries (control group) were included in the study. TyG index was calculated as ln (fasting triglyceride × fasting glucose/2). Results: There were no differences between the two groups with respect to age, sex, diabetes mellitus prevalence, and biochemical parameters including, white blood cell, platelet, lymphocyte, monocyte counts, hemoglobin, hematocrit, urea, glucose, total cholesterol, high density lipoprotein-cholesterol, triglyceride levels and TyG index value. Twenty-five patients (41.0%) had one-vessel involvement, 24 (39.3%) patients had twovessel involvement and 12 (19.7%) patients had three-vessel involvement. Right coronary artery was the most commonly affected vessel (11, 44%), followed by left anterior descending artery (8, 35%), left main coronary artery (4, 16%) and circumflex artery (1, 4%). TyG index was statistically significantly higher in patients who had two/three vessel involvement (8.80 ± 0.48 vs 9.14 ± 0.62, p= 0.027). TyG index had statistically significant correlation with the number of ectatic vessels (r= 0.275, p= 0.032). ROC curve analysis showed that TyG index was useful for the prediction of ectasia severity (AUC= 0.653, 95% CI= 0.515-0.792, p= 0.043). TyG index value of 9.16 had 41.7% sensitivity and 84% specificity for prediction of CAE severity. Conclusion: TyG index, which is easily calculated from biochemical parameters, might be used for the assessment of CAE severity.
2023-01-01T00:00:00ZTYMPANIC MEMBRANE TEMPERATURES OF VERTIGINOUS PATIENTS
http://hdl.handle.net/11446/4946
TYMPANIC MEMBRANE TEMPERATURES OF VERTIGINOUS PATIENTS
Botanlıoğlu, Tuğçe Türker; Çelikoyar, M. Mazhar; Yürekli, Zeynep Serra
Objective: This study aimed to determine the differences between the right and left ear temperatures of patients with vertigo. It also aimed to correlate the results in order to develop definitions for the pathophysiology of the diseases based on the data. Thus, we designed a study to record bilateral tympanic membrane temperatures on 137 vertiginous patients who were seen at our vertigo clinic. Materials and Methods: The study was carried out in patients who applied to Istanbul Florence Nightingale Hospital Ear, Nose and Throat Diseases Clinic with the complaint of dizziness. After confirming that there was no abnormality in the otoscopic examination, the temperature of both ears were measured with a thermometer, prior to the vestibular examination being carried out in the vestibular laboratory with the presumptive diagnosis of true vertigo. The data recorded include the patient's demographic information, examination findings, and the results obtained from the vestibular laboratory. Mean, standard deviation, median, minimum, maximum value frequency, and percentage were used for descriptive statistics. Results: A total of 137 patients were included in the study. No significant (p > 0.05) difference was observed between pathologic Side and other Side measurements in the benign paroxysmal positional vertigo (BPPV) group, Ménière's disease group, or vestibulopathy group. Nystagmus at presentation in the group without otologic pathology, i.e. those patients without overt vestibular pathology, was significantly (p < 0.05) higher than in the BPPV, Meniere's, or vestibulopathy groups. Conclusion: Our study failed to disclose any significant difference of tympanic membrane temperatures in patients with vertiginous complaints.
2022-01-01T00:00:00ZEvaluation of Clinical, Radiological and Functional Outcomes of Surgically Treated Ankle Fractures
http://hdl.handle.net/11446/4947
Evaluation of Clinical, Radiological and Functional Outcomes of Surgically Treated Ankle Fractures
Orhan, Şafak; Karaduman, Zekeriya Okan; Orhan, Zafer; Güle, Cemal; Arıcan, Mehmet; Turhal, Ozan; Turhan, Yalcin
Objective: The ankle is an important joint in the walking function of the body. Surgical treatment is required in cases where displaced and unstable fractures and joint compatibility cannot be achieved by conservative methods. The main goal of surgical treatment is to restore the anatomical position of the talus within the ankle for a normal tibiotalar joint relationship. Methods: 73 patients who were admitted to our outpatient clinics between January 2006 and October 2015, who were diagnosed with ankle fracture and underwent surgical treatment, were retrospectively evaluated and compared with the intact ankle. Results: Of the patients who had surgery; Bimalleol fracture in 34 (46.58%), trimalleol fracture in 8 (10.96%), lateral malleolar fracture in 14 (19.18%), medial malleolar fracture in 13 (17.81%), with posterior malleolar fracture in 1 ankle dislocation (1.37%) and 1 had posterior malleolar fracture with medial malleolus fracture (1.37%). According to the Lauge Hansen classification, the most common type of SER (Supination External Rotation) fracture (14 cases) (19.18%), followed by the second most common PER (Pronation External Rotation) fracture type (14 cases) (19.18%). According to the Danis - Weber classification, Type C (21 cases) (52.50%) was the most common and Type B (14 cases) (35.00%) was the second most common. When the union time was analyzed according to the fracture type, no statistically significant difference was observed (p=0.064). Conclusions: If surgical treatment is applied in ankle fractures the length of the fibula should be ensured, rigid internal fixation should be made with the aim of anatomical reduction of the joint surface, and ankle movements should be started early.
2022-01-01T00:00:00ZThe Relationship Between KRAS Mutation and 18F-FDG Uptake Parameters in Colorectal Cancer
http://hdl.handle.net/11446/4948
The Relationship Between KRAS Mutation and 18F-FDG Uptake Parameters in Colorectal Cancer
Akkalp, Aslı Kahraman; Vartanoğlu, Talar; Çelebi, Fatih; Tokoçin, Merve; Ozen, Aynur; Menekse, Serkan; Namal, Esat
Objective: Our purpose in this study was to evaluate whether Kirsten rat sarcoma viral oncogene (KRAS) exon-2 mutation affected 18F-fluorodeoxyglucose (FDG) accumulation patterns, total lesion glycolysis and metabolic tumor volume in colorectal cancer. Method: This retrospective study included 52 colorectal cancer patients. Dual-time 18F-FDG positron emission tomography/computed tomography (PET/CT) parameters such as the maximum standardized uptake values (SUVmax), tumor-to-liver parenchyma SUVmax ratios (TLR), retention index (RI), metabolic tumor volumes (MTV), total lesion glycolysis (TLG) and glucose corrected-TLGs were measured. Results: There were no statistical differences in PET/CT imaging parameters between mutated and wild-type colon cancer, but RI and RI (TLR) values were statically higher in wild-type than in mutated-type. KRAS exon-2 wild-type rectal cancer patients had low MTV (p=0.044). KRAS mutation status was correlated with MTV (r=-0.277, p=0.048). ROC curves analysis showed that MTV and MTV (%) predicted KRAS exon-2 mutation status accurately. Conclusion: Although we did not find a relationship between KRAS exon-2 mutation status and increased 18F-FDG uptake in both colon and rectal cancer patients in our study, KRAS exon-2 wild-type colon cancer patients showed interestingly increased uptake of 18F-FDG in time. Even if we find a correlation between KRAS exon-2 mutation status and MTV, it was not very strong.
2022-01-01T00:00:00Z