The evaluation of the therapeutic effect of memantine in sepsis induced critical illness polyneuropathy

Abstract

Objectives: The purpose of our study is to investigate the effects of the different dosage of memantine for the treatment of Critical Illness Polyneuropathy (CIP) in rats that have surgically induced sepsis, by using electromyography (EMG) signs, such as amplitude and duration of compound muscle action potentials (CMAP), distal latency, and by using levels of plasma tumor necrosis factor (TNF)-α and lipid peroxides (malondialdehyde, (MDA)).

Çalışmamızın amacı, sıçanlarda cerrahi olarak geliştirilen sepsis indükte kritik hastalık polinöropatisindeki memantinin farklı dozdaki etkilerini, elektromiyografi (EMG) bulgularından birleşik kas aksiyon potansiyelleri (BKAP), distal latans gibi EMG bulguları ve plazma tümör nekrotizan faktör –α (TNF-α) ve malonedialdehit (MDA, plazma lipit peroksidaz göstergesi) seviyeleri eşliğinde incelemektir.