The prognostic impact of molecular subtypes and very young age on breast conserving surgery in early stage breast cancer
Pilancı, Kezban Nur
Köksal, Ülkühan I
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CitationOrdu C, McGuire K, Alco G, Nur Pilanci K, Koksal UI, Elbüken F, Erdogan Z, Agacayak F, Ilgun S, Sarsenov D, Öztürk A, İğdem Ş, Okkan S, Eralp Y, Dincer M, Ozmen V. The prognostic impact of molecular subtypes and very young age on breast conserving surgery in early stage breast cancer. Cureus. 2016; 8(6): e633. doi: 10.7759/cureus.633.
Background: Premenopausal breast cancer with a triple-negative phenotype (TNBC) has been associated with inferior locoregional recurrence free survival (LRFS) and overall survival (OS) after breast conserving surgery (BCS). The aim of this study is to analyze the association between age, subtype, and surgical treatment on survival in young women (≤40 years) with early breast cancer in a population with a high rate of breast cancer in young women. Methods: Three hundred thirty-two patients ≤40 years old with stage I-II invasive breast cancer who underwent surgery at a single institution between 1998 and 2012 were identified retrospectively. Uni- and multivariate analysis evaluated predictors of LRFS, OS, and disease free survival (DFS).