Yazar "0000-0001-8463-5561" için Scopus İndeksli Yayınlar Koleksiyonu listeleme
-
Biochemical and immunohistochemical changes in delta-9-tetrahydrocannabinol-treated type 2 diabetic rats
Coskun, Zeynep Mine; Bolkent, Sema (ELSEVIER GMBH, URBAN & FISCHER VERLAG, 2014)The regulation of glucose, lipid metabolism and immunoreactivities of insulin and glucagon peptides by delta-9-tetrahydrocannabinol (Delta(9)-THC) in diabetes were examined in an experimental rat model. Male Sprague-Dawley ... -
CB-1R and GLP-1R gene expressions and oxidative stress in the liver of diabetic rats treated with sitagliptin
Coskun, Zeynep Mine; Koyuturk, Meral; Karabulut, Sezin; Bolkent, Sema (POLISH ACAD SCIENCES INST PHARMACOLOGY, 2017)Background: Type 2 diabetes is a major health problem affecting millions of people.Controlled eating and regular physical activity are important for the management of type 2 diabetes. Dipeptidyl peptidase-4 enzyme (DPP-4) ... -
Delta(9)-tetrahydrocannabinol treatment improved endothelium-dependent relaxation on streptozotocin/nicotinamide-induced diabetic rat aorta
Altinok, A.; Coskun, Z. M.; Karaoglu, K.; Bolkent, S.; Akkan, A. G.; Ozyazgan, S. (AKADEMIAI KIADO RT, 2015)Objective: In this study, we investigated the possible effect of Delta(9)-tetrahydrocannabinol (THC), a peroxisome proliferator-activated receptor gamma (PPAR.) agonist, on metabolic control and vascular complications of ... -
Dipeptidyl peptidase-4 inhibition prevents cell death via extrinsic and intrinsic apoptotic pathways in rat pancreas with insulin resistance
Nephan, Gulay; Coskun, Zeynep Mine; Bolkent, Sema (WILEY, 2018)The study aims to evaluate the effect of saxagliptin, a specific inhibitor of dipeptidyl peptidase-4 enzymes, on body weight gain, lipid profiles, and cell death through apoptosis in rats with insulin resistance (IR). Male ... -
Immunohistochemical, apoptotic and biochemical changes by dipeptidyl peptidase-4 inhibitor-sitagliptin in type-2 diabetic rats
Karabulut, Sezin; Coskun, Zeynep Mine; Bolkent, Sema (POLISH ACAD SCIENCES INST PHARMACOLOGY, 2015)Background: Diabetes is a major public health problem that is rapidly increasing in prevalence. In this study, the effects of sitagliptin, a dipeptidyl peptidase-4 inhibitor, were examined on newborn diabetic rat model. ... -
The protective effects of Delta(9)-tetrahydrocannabinol against inflammation and oxidative stress in rat liver with fructose-induced hyperinsulinemia
Beydogan, Alisa Bahar; Coskun, Zeynep Mine; Bolkent, Sema (WILEY, 2019)Objectives A large amount of fructose is metabolized in the liver and causes hepatic functional damage. Delta(9)-tetrahydrocannabinol (THC) is known as a therapeutic agent for clinical and experimental applications. The ... -
Regulation of gene expression and biochemical changes in small intestine of newborn diabetic rats by exogenous ghrelin
Karatug, Ayse; Sacan, Ozlem; Coskun, Zeynep Mine; Bolkent, Sehnaz; Yanardag, Refiye; Turk, Neslihan; Bolkent, Sema (ELSEVIER SCIENCE INC, 2012)The aim of this study was to investigate (i) the cholecystokinin, somatostatin and apelin mRNA levels, (ii) the changes in levels and localization of these peptides, (iii) relation between these peptides, (iv) anti-apoptotic ... -
The Role of Delta(9)-Tetrahydrocannabinol in Diabetes Mellitus
Coskun, Z. M.; Bolkent, S. (ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD, 2017)…