Changes in serum paraoxonase activity, calcium and lipid profiles in pre-eclampsia, a preliminary study

Abstract

Amaç: Preeklamptik ve normotansif gebelerde serum paraoxonaz (PON1) aktivitesi, serum kalsiyumu ve lipid profillerinin incelenmesi. Gereç ve yöntemler: 34 preeklamptik ve 11 normotansif gebede serum PON1 aktivitesi, kalsiyum ve lipid profillerinin incelenmesi. Bulgular: Preeklamptik gebelerde serum trigliserid, total kolesterol, LDL kolesterol sevyeleri, normotansif gebelerle kıyaslandığında anlamlı olarak daha yüksek bulunmuştur. Serum HDL kolesterol, PON1, ve kalsiyum sevyeleri ise normal gebelere kıyasla preeklamptik kadınlarda daha düşük olarak tespit edilmiştir. Sonuç: Preeklamptik hastalarda PON1 aktivitesindeki anlamlı düşüş, lipid profili ve kalsiyum seviyesi ile ilişkilidir.

Objective: To investigate serum paraoxonase (PON1) activity, serum calcium, and lipid profiles in pre-eclampsia. Material and methods: Serum PON1 activity, calcium, and lipid profiles were measured in a cohort of 45 women with normal pregnancies (11 patients) and pre-eclampsia (34 patients).Results: Triglyceride, total cholesterol, and LDL cholesterol concentrations were significantly increased in women with pre-eclampsia, compared with women with normal pregnancies. Serum HDL cholesterol, PON1, and calcium levels in pre-eclamptic patients were significantly lower than those in healthy pregnant women. Conclusion: The significant decrease of PON1 activity in pre-eclampsia is related to lipid profiles and calcium.