Demonstration of PTZ-induced convulsive-reducing effect of butamirate citrate

Abstract

Butamirate has the possible effects on epileptic seizures, which is thought to perform central antitussive effect via medulla oblongata and nucleus tractus solitarius. In our study, these effects have been investigated on electrophysiological and clinical basis. 48 Sprague-Dawley rats were divided randomly into two groups for EEG recordings and behavioral assesment then these two groups divided to four groups: 6 for control, 6 for saline injection, 6 for relatively-low dose butamirate (5 mg/kg) and 6 for relatively-high dose butamirate (10 mg/kg) for each. Evaluation of the behavioral analyses after giving 70 mg/kg pentylenetetrazol (PTZ) first myoclonic jerk time and racine convulsion scales were analyzed, then in different rats for EEG recordings 35 mg/kg PTZ were given and spike percentages were evaluated in same doses of butamirate. In both 5 mg/kg and 10 mg/kg butamirate groups the FMJ onset times were statistically higher then the saline group, similarly both 5 and 10 mg/kg butamirate groups RCS scores were significantly lower than the saline group. In terms of spike percentages, 5 and 10 mg/kg butamirate were significantly lower than the saline group. As a result in our study, we showed that 5 and 10 mg/kg doses of butamirate have anticonvulsant effects on PTZ induced rats. © 2018, Anka Publishers. All rights reserved.