C-reactive protein and lipoprotein-a as markers of coronary heart disease in polycystic ovary syndrome [Polikistik over sendromlu hastalarda koroner kalp hastali{dotless}klari{dotless}ni{dotless}n belirteci olarak c-reaktif protein ve lipoprotein-a baki{dotless}lmasi{dotless}]

Abstract

Objective: The aim of this study was to investigate the risk factors of coronary heart disease, CRP and Lipoprotein-a in polycystic ovary syndrome patients. Material and Methods: Prospectively collected data of polycystic ovary syndrome patients (n=62) and control group (n=40) were compared. Results: PCOS patients had higher HOMA-IR, CRP, DHEAS, free testosterone, FAI, LH and prolactin levels when compared to the control group. Lipoprotein-a levels did not differ between the groups. The obese PCOS group had statistically significantly higher fasting blood glucose, total cholesterol, triglyceride, free testosterone, insulin, CRP and HOMA-IR and statistically significantly lower HDL and SHBG when compared to normal weight PCOS persons. Fasting blood glucose, total cholesterol, LDL, SHBG, CRP, Lipoprotein-a, FSH, LH, TSH, DHEAS and prolactin levels did not differ between the normal weight and obese control groups. Conclusion: CRP levels increase in polycystic ovary syndrome patients and can be used as a marker of coronary heart disease. Future studies can be directed at treatments to decrease CRP levels, including antiinflammatory treatments. ©Copyright 2012 by the Turkish-German Gynecological Education and Research Foundation.