dc.contributor.author | Akun E. | |
dc.contributor.author | Okutur K. | |
dc.contributor.author | Seber S. | |
dc.contributor.author | Korkmaz T. | |
dc.contributor.author | Aydin K. | |
dc.contributor.author | Bozkurt M. | |
dc.contributor.author | Demir G. | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T15:53:21Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T15:53:21Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1107-0625 | |
dc.identifier.uri | http://hdl.handle.net/11446/1905 | |
dc.description | PubMed ID: 23335523 | en_US |
dc.description.abstract | Purpose: To determine the clinical features of bevacizumab-associated toxicities in metastatic colorectal cancer (MCRC) patients. Methods: The medical records of 60 patients with MCRC who were treated with chemotherapy including bevacizumab in the first-line setting were retrospectively evaluated. Results: Bevacizumab was administered along with irinotecan plus 5-fluorouracil/ leucovorin (5-FU/LV) to 44 patients, 5-FU/LV+oxaliplatin to 8 patients, capecitabine+oxaliplatin to 6 patients and 5-FU/LV to 2 patients. The total number of the cycles received was 381 (median 6, range 1-13). The most common bevacizumab-related toxicity was grade 1-2 bleeding (28%) followed by hypertension (17%). Grade 1-2 proteinuria was seen in 8% of the patients (no grade 3-4 proteinuria). Arterial thromboembolic events (ATE) were not observed, however 3 patients (5%) had experienced grade 3-4 venous thromboembolic events. In 3 patients (5%) grade 1-2 wound complications were seen (delayed wound healing in the place of the venous access device in 2, and wound infection in 1). In addition, gastrointestinal perforation (GIP) was seen in 3 (5%) patients. Two of the patients were treated by surgical intervention and one patient died of sepsis. Conclusion: Bevacizumab is well tolerated when combined with various chemotherapy regimens. As bevacizumab is becoming widely used in the routine oncology practice, further studies which investigate the mechanism of bevacizumab-associated toxicities are warranted to develop effective management strategies for these adverse events. | en_US |
dc.language.iso | eng | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Bevacizumab | en_US |
dc.subject | Bleeding | en_US |
dc.subject | Colorectal cancer | en_US |
dc.subject | Gastrointestinal perforation | en_US |
dc.subject | Hypertension | en_US |
dc.subject | Thromboembolism | en_US |
dc.title | Safety and tolerability of first-line bevacizumab in metastatic colorectal cancer | en_US |
dc.type | article | en_US |
dc.relation.journal | Journal of B.U.ON. | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.startpage | 669 | en_US |
dc.identifier.endpage | 676 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | DBÜ | en_US |