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dc.contributor.authorDuman B.S.
dc.contributor.authorCagatay P.
dc.contributor.authorHatemi H.
dc.contributor.authorÖztürk M.
dc.date.accessioned2019-08-13T12:10:23Z
dc.date.accessioned2019-08-13T15:53:41Z
dc.date.available2019-08-13T12:10:23Z
dc.date.available2019-08-13T15:53:41Z
dc.date.issued2007
dc.identifier.issn1613-6071
dc.identifier.urihttps://dx.doi.org/10.1900/RDS.2007.4.49
dc.identifier.urihttp://hdl.handle.net/11446/1999
dc.description.abstractResistin, an adipocyte-secreted hormone, has been associated with obesity, insulin resistance and type 2 diabetes mellitus (T2DM) in some, but not all, rodent models. In humans, the exact function of resistin is unkown. Because 3?-untranslated region (3?-UTR) single nucleotide substitutions (SNPs) have been shown to affect gene expression, we examined the EX4-44G?A SNP in the 3?-UTR of exon 3 within the resistin gene. The objective of this study was to investigate, for the first time in a Turkish study group, whether the 3?-UTR EX4-44G?A variation in the resistin gene influences the development of T2DM, obesity and insulin-related phenotypes. We analyzed the genotype frequencies of the EX4-44G?A polymorphism of the resistin gene in 116 type 2 diabetic and 102 normal subjects. Serum lipids, obesity-related and insulin-related phenotypes were analyzed. No significant difference for genotypic frequencies were observed for the BseRI restriction site in type 2 diabetic patients as compared to controls. Waist-to-hip ratio, BMI, body fat and apoAI levels were found to be affected by resistin genotype. In the control group, BMI (p < 0.01), HIS (p < 0.05) and BF (p < 0.05) levels were found to be elevated, whereas HOMA ?-cell index (p < 0.01) and apo AI (p < 0.05) levels were found to be decreased in GG genotype carriers. In the diabetic group, the GG genotype carriers were found to have higher BMI levels (p<0.001), waist-to-hip ratio (p < 0.05), body fat (p < 0.01), HOMA (p < 0.001) and fasting insulin (p < 0.05), but lower HbA1c levels in comparison to GC + AA carriers. These data suggest that, in the Turkish study group, the EX4-44G?A polymorphism of the resistin gene is associated with insulin and obesity-related phenotypes.en_US
dc.language.isoengen_US
dc.identifier.doi10.1900/RDS.2007.4.49en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBody faten_US
dc.subjectEX4-44G?A polymorphismen_US
dc.subjectInsulin resistanceen_US
dc.subjectObesityen_US
dc.subjectResistinen_US
dc.subjectType 2 diabetesen_US
dc.titleAssociation of resistin gene 3?-untranslated region EX4-44G?A polymorphism with obesity- and insulin-related phenotypes in Turkish type 2 diabetes patientsen_US
dc.typearticleen_US
dc.relation.journalReview of Diabetic Studiesen_US
dc.departmentDBÜen_US
dc.identifier.issue1en_US
dc.identifier.volume4en_US
dc.identifier.startpage49en_US
dc.identifier.endpage55en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-tempDBÜen_US


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