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dc.contributor.authorCagatay P.
dc.contributor.authorSusleyici-Duman B.
dc.contributor.authorCiftci C.
dc.date.accessioned2019-08-13T12:10:23Z
dc.date.accessioned2019-08-13T15:53:42Z
dc.date.available2019-08-13T12:10:23Z
dc.date.available2019-08-13T15:53:42Z
dc.date.issued2007
dc.identifier.issn0278-0240
dc.identifier.urihttps://dx.doi.org/10.1155/2007/863712
dc.identifier.urihttp://hdl.handle.net/11446/2004
dc.descriptionPubMed ID: 17473385en_US
dc.description.abstractOur aim was to determine whether lipoprotein lipase gene PvuII polymorphism can be considered as an independent risk factor for coronary artery disease (CAD) by conducting a meta-analysis of all available published trials, including our own study. In 7 seperate studies, 3289 subjects were screened for this substitution; meta-analysis included only some of these individuals. Among the 7 studies, 6 were performed on white subjects, whereas 1 was on patients with Saudi Arabic descent.Subgroup analysis indicated that individuals with PvuII substitution does not have an increased risk for CAD. The LPL-PvuII genotype and allele frequency distributions did not differ significantly between CAD patients and healthy controls. There was no difference in the distribution of LPL-PvuII genotypes between the healthy subjects and the patients with CAD. However, no significant differences in lipid variables (triglyceride and HDL-cholesterol) were determined for the PvuII polymorphisms in the patients with CAD. No significant differences were found in serum triglyceride and HDL-cholesterol levels for LPL-PvuII genotypes when the control and CAD groups were pooled. In conclusion, LPL-Pvu II polymorphism cannot be used as independent genetic risk factor for CAD. © 2007 - IOS Press and the authors. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherIOS Pressen_US
dc.relation.isversionof10.1155/2007/863712en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectGenetic polymorphismen_US
dc.subjectLipoprotein lipaseen_US
dc.subjectMeta-analysisen_US
dc.titleLipoprotein lipase gene PvuII polymorphism serum lipids and risk for coronary artery disease: Meta-analysisen_US
dc.typearticleen_US
dc.relation.journalDisease Markersen_US
dc.contributor.departmentDBÜen_US
dc.identifier.issue3en_US
dc.identifier.volume23en_US
dc.identifier.startpage161en_US
dc.identifier.endpage166en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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