dc.contributor.author | Cagatay P. | |
dc.contributor.author | Susleyici-Duman B. | |
dc.contributor.author | Ciftci C. | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T15:53:42Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T15:53:42Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0278-0240 | |
dc.identifier.uri | https://dx.doi.org/10.1155/2007/863712 | |
dc.identifier.uri | http://hdl.handle.net/11446/2004 | |
dc.description | PubMed ID: 17473385 | en_US |
dc.description.abstract | Our aim was to determine whether lipoprotein lipase gene PvuII polymorphism can be considered as an independent risk factor for coronary artery disease (CAD) by conducting a meta-analysis of all available published trials, including our own study. In 7 seperate studies, 3289 subjects were screened for this substitution; meta-analysis included only some of these individuals. Among the 7 studies, 6 were performed on white subjects, whereas 1 was on patients with Saudi Arabic descent.Subgroup analysis indicated that individuals with PvuII substitution does not have an increased risk for CAD. The LPL-PvuII genotype and allele frequency distributions did not differ significantly between CAD patients and healthy controls. There was no difference in the distribution of LPL-PvuII genotypes between the healthy subjects and the patients with CAD. However, no significant differences in lipid variables (triglyceride and HDL-cholesterol) were determined for the PvuII polymorphisms in the patients with CAD. No significant differences were found in serum triglyceride and HDL-cholesterol levels for LPL-PvuII genotypes when the control and CAD groups were pooled. In conclusion, LPL-Pvu II polymorphism cannot be used as independent genetic risk factor for CAD. © 2007 - IOS Press and the authors. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | IOS Press | en_US |
dc.identifier.doi | 10.1155/2007/863712 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Coronary artery disease | en_US |
dc.subject | Genetic polymorphism | en_US |
dc.subject | Lipoprotein lipase | en_US |
dc.subject | Meta-analysis | en_US |
dc.title | Lipoprotein lipase gene PvuII polymorphism serum lipids and risk for coronary artery disease: Meta-analysis | en_US |
dc.type | article | en_US |
dc.relation.journal | Disease Markers | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.volume | 23 | en_US |
dc.identifier.startpage | 161 | en_US |
dc.identifier.endpage | 166 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | DBÜ | en_US |