dc.contributor.author | Al-Hayali, Mutaa Abdalmutaleb | |
dc.contributor.author | Sozer, Volkan | |
dc.contributor.author | Durmus, Sinem | |
dc.contributor.author | Erdenen, Fusun | |
dc.contributor.author | Altunoglu, Esma | |
dc.contributor.author | Gelisgen, Remise | |
dc.contributor.author | Uzun, Hafize | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T15:55:25Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T15:55:25Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 2218-273X | |
dc.identifier.uri | https://dx.doi.org/10.3390/biom9050193 | |
dc.identifier.uri | http://hdl.handle.net/11446/2017 | |
dc.description | WOS: 000472671400033 | en_US |
dc.description | PubMed ID: 31109008 | en_US |
dc.description.abstract | To investigate whether the circulating miR-1 (microRNA-1) and miR-21 expression might be used in the diagnosis of heart failure (HF) and silent coronary artery disease (SCAD) in asymptomatic type 2 diabetes mellitus (T2DM) patients and to explore the relationship of these miRs with N-terminal pro-brain natriuretic peptide (NT-proBNP) and galectin-3. One hundred thirty-five consecutive patients with T2DM and 45 matched control subjects were enrolled in the study. This study consisted of the following four groups: control group (mean age: 60.23 +/- 6.27 years, female/male (F/M): 23/22); diabetic group (DM) (mean age: 61.50 +/- 5.08, F/M: 23/22); DM + SCAD group (mean age: 61.61 +/- 6.02, F/M: 20/25); and DM + acute HF group (mean age: 62.07 +/- 5.26 years, F/M: 20/25). miR-1 was downregulated in the DM, CAD + DM and HF + DM groups by 0.54, 0.54, and 0.12 fold as compared with controls, respectively. The miR-1 levels were significantly lower in HF + DM than DM with 0.22 fold changes (p < 0.001); and in patients with CAD + DM group with 0.22 fold changes (p < 0.001). Similarly, miR-21 was overexpressed in patients with DM, CAD + DM, and HF + DM with 1.30, 1.79 and 2.21 fold changes as compared with controls, respectively. An interesting finding is that the miR-21 expression was significantly higher in the HF + DM group as compared with the CAD + DM group; miR-1 was negatively correlated with NT-proBNP (r = -0.891, p < 0.001) and galectin-3 (r = -0.886, p < 0.001) in the HF + DM group; and miR-21 showed a strongly positive correlation with (r = 0.734, p < 0.001) and galectin-3 (r = 0.764. p < 0.001) in the HF + DM group. These results suggest that the circulating decreased miR-1 and increased miR-21 expression are associated with NT-proBNP and galectin-3 levels in acute HF + DM. Especially the miR-21 expression might be useful in predicting the onset of acute HF in asymptomatic T2DM patients. The miR-21 expression is more valuable than the miR-1 expression in predicting cardiovascular events of acute HF and the combined analysis of miR-21 expression, galectin-3, and NT-proBNP can increase the predictive value of miR-21 expression. | en_US |
dc.description.sponsorship | Research Fund of Yildiz Technical University, Turkey [TDK-2018-3180] | en_US |
dc.description.sponsorship | This research was funded by the Research Fund of Yildiz Technical University, Turkey, grant number: TDK-2018-3180 | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.identifier.doi | 10.3390/biom9050193 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | asymptomatic type 2 diabetes mellitus | en_US |
dc.subject | acute heart failure | en_US |
dc.subject | silent coronary artery disease | en_US |
dc.subject | NT-proBNP | en_US |
dc.subject | galectin-3 | en_US |
dc.subject | miRNA-1 | en_US |
dc.subject | miRNA-21 | en_US |
dc.title | Clinical Value of Circulating Microribonucleic Acids miR-1 and miR-21 in Evaluating the Diagnosis of Acute Heart Failure in Asymptomatic Type 2 Diabetic Patients | en_US |
dc.type | article | en_US |
dc.relation.journal | BIOMOLECULES | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.volume | 9 | en_US |
dc.contributor.authorID | 0000-0002-2286-2416 | en_US |
dc.contributor.authorID | 0000-0003-1633-6409 | en_US |
dc.contributor.authorID | 0000-0002-9272-9098 | en_US |
dc.contributor.authorID | 0000-0002-1347-8498 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Al-Hayali, Mutaa Abdalmutaleb -- Sozer, Volkan] Yildiz Tech Univ, Dept Biochem, TR-34220 Istanbul, Turkey -- [Al-Hayali, Mutaa Abdalmutaleb] Univ Mosul, Dept Physiol Biochem & Pharmacol, Coll Vet Med, Mosul 09334, Iraq -- [Durmus, Sinem -- Gelisgen, Remise -- Atukeren, Pinar -- Uzun, Hafize] Istanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Dept Biochem, TR-34098 Istanbul, Turkey -- [Erdenen, Fusun -- Altunoglu, Esma] Istanbul Training & Res Hosp, Dept Internal Med, TR-34098 Istanbul, Turkey -- [Atak, Palmet Gun] Istanbul Bilim Univ, Fac Med, Dept Biochem, TR-34394 Istanbul, Turkey | en_US |