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How Safe is the Use of Intrathecal Fluorescein? An Experimental Study

Date

2019

Author

Camlar, Mahmut
Turk, Caglar
Oltulu, Fatih
Oren, Merve
Buhur, Aylin
Yigitturk, Gurkan
Gazioglu, Nurperi

Metadata

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Abstract

AIM: To investigate the effects of fluorescein-sodium on neural tissues. MATERIAL and METHODS: Twenty-one Wistar rats were randomly divided into three experimental groups: control (group 1) and fluorescein-sodium groups with different doses (groups 2 and 3). In the control group, craniectomy following with durotomy was performed with the help of a loupe microscope, and a dry sponge was overlayed to the brain tissue. In the study groups, the open dura was covered with a sponge soaked with 0.02 mg (group 2) and with 0.2 mg (group 3) fluorescein sodium following craniectomy. Three weeks postoperatively, rats were sacrificed for the histopathologic evaluations. RESULTS: Fluorescein-induced apoptosis occurs in a dose-dependent manner in rats' neurons. It was determined that neuron and neuroglial cell TUNEL staining was statistically different among the three groups (p<0.001). Our results indicated that fluorescein induces apoptosis, resulting in increased nuclear factor kappa beta (NF-kappa beta) expression in a dose-dependent manner. CONCLUSION: Fluorescein sodium is used frequently during surgery for CSF fistulas. However, information in the literature about its safety is insufficient. Our study holds promise for the development of new studies on the reliability of this agent.

Source

TURKISH NEUROSURGERY

Volume

29

Issue

4

URI

https://dx.doi.org/10.5137/1019-5149.JTN.24085-18.3
http://hdl.handle.net/11446/2044

Collections

  • PubMed İndeksli Yayınlar Koleksiyonu [1178]
  • TR-Dizin İndeksli Yayınlar Koleksiyonu [877]
  • WoS İndeksli Yayınlar Koleksiyonu [1717]



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