dc.contributor.author | Ciftci, H. S. | |
dc.contributor.author | Tefik, T. | |
dc.contributor.author | Savran, M. K. | |
dc.contributor.author | Demir, E. | |
dc.contributor.author | Caliskan, Y. | |
dc.contributor.author | Ogret, Y. D. | |
dc.contributor.author | Nane, I | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T15:55:30Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T15:55:30Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 2008-6490 | |
dc.identifier.issn | 2008-6482 | |
dc.identifier.uri | http://hdl.handle.net/11446/2045 | |
dc.description | WOS: 000468209600001 | en_US |
dc.description.abstract | Background: Monitoring of chemokines, CXCL9 and CXCL10, in serum may present a non-invasive detection method for rejection. Objective: To investigate the relationship between urinary levels of CXCL9 and CXCL10 and graft function following renal transplantation. Methods: 75 living-related donor renal transplant recipients were studied. Urinary levels of chemokines were collected pre-operatively, on post-operative 1st day, 7th day, 1st month, 3rd month, and at the time of rejection. Chemokines levels were assayed using and enzyme-linked immunosorbent assay. Results: Clinical variables were monitored. 10 (15%) patients had biopsy-proven rejection during the follow-up period. The urinary CXCL9 level in those with rejection was significantly higher than that in those with non-rejection group at the 1st day (p<0.001), 7th day (p<0.001), and at the time of rejection (p=0.002). The urinary CXCL10 level was also significantly higher in those with rejection compared with non-rejection group at 1st day (p<0.001), 7th day (p<0.001), and at the time of rejection (p=0.001). Serum creatinine level was strongly correlated with the urinary CXCL9 and CXCL10 levels at the time of rejection (r=0.615, p=0.002; and r=0.519, p=0.022, respectively). Among those with T cell-mediated rejections the mean urinary CXCL10 level increased to as high as 258.12 ng/mL. Conclusion: Urinary CXCL9 and CXCL10 levels might have a predictive value for T cell-mediated rejection in early post-transplantation period. Measurement of urinary CXCL9 and CXCL10 levels could provide an additional tool for the diagnosis of rejection. | en_US |
dc.description.sponsorship | Scientific Research Projects Coordination Unit (BAP) of Istanbul University [47549] | en_US |
dc.description.sponsorship | The study was supported by the Scientific Research Projects Coordination Unit (BAP) of Istanbul University (project number 47549). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | AVICENNA ORGAN TRANSPLANT CENTER | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Chemokines | en_US |
dc.subject | Renal transplantation | en_US |
dc.subject | Rejection | en_US |
dc.subject | Biomarker | en_US |
dc.subject | Graft function | en_US |
dc.title | Urinary CXCL9 and CXCL10 Levels and Acute Renal Graft Rejection | en_US |
dc.type | article | en_US |
dc.relation.journal | INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.volume | 10 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Ciftci, H. S. -- Ogret, Y. D. -- Oguz, F. S.] Istanbul Univ, Istanbul Fac Med, Dept Med Biol, Istanbul, Turkey -- [Tefik, T. -- Oktar, T. -- Sanli, O. -- Kocak, T. -- Nane, I] Istanbul Univ, Istanbul Fac Med, Dept Urol, Istanbul, Turkey -- [Savran, M. K.] Istanbul Univ, Istanbul Fac Med, Dept Anesthesia, Istanbul, Turkey -- [Demir, E. -- Caliskan, Y. -- Turkmen, A.] Istanbul Univ, Istanbul Fac Med, Dept Nephrol, Istanbul, Turkey -- [Ozluk, Y. -- Kilicaslan, I] Istanbul Univ, Dept Pathol, Istanbul Fac Med, Istanbul, Turkey -- [Aydin, F.] Istanbul Bilim Univ, Fac Med, Dept Med Biol & Genet, Istanbul, Turkey | en_US |