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dc.contributor.authorBora, Saylav
dc.contributor.authorErdogan, Mumin Alper
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorErbas, Oytun
dc.contributor.authorParlak, Ismet
dc.date.accessioned2019-08-13T12:10:23Z
dc.date.accessioned2019-08-13T15:55:35Z
dc.date.available2019-08-13T12:10:23Z
dc.date.available2019-08-13T15:55:35Z
dc.date.issued2018
dc.identifier.issn1530-7905
dc.identifier.issn1559-0259
dc.identifier.urihttps://dx.doi.org/10.1007/s12012-018-9466-y
dc.identifier.urihttp://hdl.handle.net/11446/2071
dc.descriptionWOS: 000447648400006en_US
dc.descriptionPubMed ID: 29873021en_US
dc.description.abstractThe aim of this study was to evaluate the effects of metoprolol, lipid emulsion and MgSO4 which can be recommended for prevention of long QT that is one of the lethal consequences of amitriptyline intoxication. Thirty Sprague-Dawley male rats were included. Five groups respectively received the following: saline intraperitoneally (i.p.); amitriptyline (AMT) 100mg/kg per os (p.o.) and saline i.p.; AMT 100mg/kg p.o. and 5mg/kg metoprolol i.p.; AMT 100mg/kg p.o. and 20ml/kg lipid emulsion i.p.; AMT 100mg/kg p.o. and 75mg/kg MgSO4 i.p. After 1h, all groups were analysed by ECG recordings in DII lead; their blood was taken for biochemical examination and euthanasia was performed. For histological examination, cardiac tissues were removed and sections were prepared. QTc was significantly reduced in treatment groups compared to the AMT+saline group. When compared with the AMT+saline, lipid emulsion did not affect pro-BNP and troponin levels in biochemical analysis, but it significantly reduced Caspase 3 expression in histological examination. In the group treated with AMT and metoprolol, there was no significant effect on Caspase 3 expression. In MgSO4-treated group, there was a significant decrease in troponin, pro-BNP and urea levels biochemically and significant decrease in Caspase 3 expression histologically when compared with the control group. With further studies including clinical studies, MgSO4, lipid emulsion or metoprolol may be used to improve AMT-induced cardiotoxicity. They can possibly become alternative approaches in the future for suicidal or accidental intoxication of tricyclic antidepressant in emergency departments.en_US
dc.language.isoengen_US
dc.publisherHUMANA PRESS INCen_US
dc.relation.isversionof10.1007/s12012-018-9466-yen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDrug toxicityen_US
dc.subjectQTcen_US
dc.subjectAmitriptylineen_US
dc.subjectArrhythmiaen_US
dc.subjectElectrocardiogramen_US
dc.titleThe Effects of Lipid Emulsion, Magnesium Sulphate and Metoprolol in Amitriptyline-Induced Cardiovascular Toxicity in Ratsen_US
dc.typearticleen_US
dc.relation.journalCARDIOVASCULAR TOXICOLOGYen_US
dc.contributor.departmentDBÜen_US
dc.identifier.issue6en_US
dc.identifier.volume18en_US
dc.identifier.startpage547en_US
dc.identifier.endpage556en_US
dc.contributor.authorID0000-0002-2448-2337en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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