dc.contributor.author | Sogut, Ibrahim | |
dc.contributor.author | Paltun, Sila Ozlem | |
dc.contributor.author | Tuncdemir, Matem | |
dc.contributor.author | Ersoz, Melike | |
dc.contributor.author | Hurdag, Canan | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T15:55:55Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T15:55:55Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0008-4212 | |
dc.identifier.issn | 1205-7541 | |
dc.identifier.uri | https://dx.doi.org/10.1139/cjpp-2017-0487 | |
dc.identifier.uri | http://hdl.handle.net/11446/2167 | |
dc.description | WOS: 000428569300012 | en_US |
dc.description | PubMed ID: 28898587 | en_US |
dc.description.abstract | The harmful use of alcohol is a worldwide problem involving all ages. This study aims to investigate chronic alcohol exposure related hepatotoxicity on the rat liver and possible hepatoprotective effects of boric acid. Rats were separated into 4 different groups: control, ethanol, ethanol+boric acid, and boric acid. We measured (i) malondialdehyde (MDA), total sialic acid (TSA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) levels, which are known to be the markers of alcohol damage; and also (ii) caspase-3, tumor necrosis factor-alpha (TNF-alpha), and the terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) as the markers of apoptosis. In the ethanol group, MDA, TSA, and TNF-alpha levels increased whereas SOD and CAT levels decreased compared with the control group. Ethanol+boric acid group MDA, TSA, caspase-3, and TNF-alpha levels decreased whereas SOD and CAT levels increased compared with the ethanol group. Using histopathological evaluation of light microscope images, immunohistochemical caspase-3 and TNF-alpha activity in the ethanol+boric acid group were shown to be decreased compared with that in the ethanol group. Our results revealed that ethanol is capable of triggering oxidative stress and apoptosis in the rat liver. We propose that boric acid is an effective compound in protecting the rat liver against ethanol. | en_US |
dc.description.sponsorship | Scientific and Technological Research Council of Turkey [113S546] | en_US |
dc.description.sponsorship | This work was supported by the Scientific and Technological Research Council of Turkey (Project No. 113S546). The authors thank Esra Cikler Dulger, Melis Savasan Sogut, Albena Gayef, Aysegul Oglakci, and Sakir Sekmen for their efforts in this study. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS | en_US |
dc.identifier.doi | 10.1139/cjpp-2017-0487 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | apoptosis | en_US |
dc.subject | boric acid | en_US |
dc.subject | chronic alcohol consumption | en_US |
dc.subject | hepatotoxicity | en_US |
dc.subject | oxidative stress | en_US |
dc.title | The antioxidant and antiapoptotic effect of boric acid on hepatoxicity in chronic alcohol-fed rats | en_US |
dc.type | article | en_US |
dc.relation.journal | CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.volume | 96 | en_US |
dc.identifier.startpage | 404 | en_US |
dc.identifier.endpage | 411 | en_US |
dc.contributor.authorID | 0000-0002-5300-4449 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Sogut, Ibrahim] Istanbul Bilim Univ, Vocat Sch Hlth Serv, Istanbul, Turkey -- [Paltun, Sila Ozlem -- Hurdag, Canan] Istanbul Bilim Univ, Fac Med, Dept Histol & Embryol, Istanbul, Turkey -- [Tuncdemir, Matem] Istanbul Univ, Dept Med Biol, Fac Med, Istanbul, Turkey -- [Ersoz, Melike] Istanbul Bilim Univ, Fac Arts & Sci, Dept Mol Biol & Genet, Istanbul, Turkey -- [Sogut, Ibrahim] Otto Von Guericke Univ, Dept Clin Chem & Pathochem, Magdeburg, Germany | en_US |