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dc.contributor.authorKahraman, Serkan
dc.contributor.authorDogan, Ali
dc.contributor.authorZiyrek, Murat
dc.contributor.authorUsta, Emrah
dc.contributor.authorDemiroz, Onder
dc.contributor.authorCiftci, Cavlan
dc.date.accessioned2019-08-13T12:10:23Z
dc.date.accessioned2019-08-13T15:56:00Z
dc.date.available2019-08-13T12:10:23Z
dc.date.available2019-08-13T15:56:00Z
dc.date.issued2018
dc.identifier.issn2148-4902
dc.identifier.urihttps://dx.doi.org/10.14744/nci.2017.26779
dc.identifier.urihttp://hdl.handle.net/11446/2191
dc.descriptionWOS: 000453318400008en_US
dc.descriptionPubMed ID: 30859163en_US
dc.description.abstractOBJECTIVE: Uncontrolled inflammatory responses could contribute to the pathogenesis of many leading causes of human morbidity and mortality. Aspirin is an anti-inflammatory and antithrombotic drug that is used in the primary and secondary protection in atherothrombotic diseases and complications. The aim of the present study was to analyze the effect of aspirin resistance on the extent and severity of atherosclerosis. METHODS: One hundred patients who underwent coronary angiography with suspected or known coronary artery disease and were using aspirin were enrolled in the study. RESULTS: Of these 100 patients, 30 (8 female and 22 male) formed the aspirin-resistant group (ARG), and 70 (22 female and 48 male) formed the control group. Gensini scoring system (GSS) was significantly higher in the ARG than in the control group (80.5 (36-166) vs. 45 (2-209); p<0.001). The number of percutaneous coronary intervention (PCI) patients was significantly higher in the ARG (13 of 30 (43.3%) ARG vs. 13 of 70 (18.6%) control group; p=0.01). Furthermore, when we evaluate the 16 reintervention patients, stent restenosis was significantly higher in the ARG (11 of 16 (68.75%) ARG vs. 5 of 16 (31.25%) control group; p=0.016). Multivariate logistic regression analysis revealed that GSS (p=0.038; 95% CI: 1.001-1.026) and PCI history (p=0.017; 95% CI: 1.182-89.804) were independent risk factors for aspirin resistance. CONCLUSION: In conclusion, atherosclerotic burden as calculated by the GSS is significantly higher in aspirin-resistant patients. According to this result, we suggest that aspirin treatment can be prescribed in higher doses in aspirin resistance patients with coronary events. Furthermore, GSS and PCI history could be independent predictors of aspirin resistance.en_US
dc.language.isoengen_US
dc.publisherKARE PUBLen_US
dc.relation.isversionof10.14744/nci.2017.26779en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAspirin resistanceen_US
dc.subjectatherosclerosisen_US
dc.subjectcoronary artery diseaseen_US
dc.titleThe association between aspirin resistance and extent and severity of coronary atherosclerosisen_US
dc.typearticleen_US
dc.relation.journalNORTHERN CLINICS OF ISTANBULen_US
dc.contributor.departmentDBÜen_US
dc.identifier.issue4en_US
dc.identifier.volume5en_US
dc.identifier.startpage323en_US
dc.identifier.endpage328en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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