dc.contributor.author | Sengul, Elvan Alper | |
dc.contributor.author | Artunay, Ozgur | |
dc.contributor.author | Rasier, Rifat | |
dc.contributor.author | Kockar, Alev | |
dc.contributor.author | Afacan, Ceyda | |
dc.contributor.author | Hancer, Veysel Sabri | |
dc.contributor.author | Yuzbasioglu, Erdal | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T15:56:02Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T15:56:02Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0927-3948 | |
dc.identifier.issn | 1744-5078 | |
dc.identifier.uri | https://dx.doi.org/10.1080/09273948.2017.1311925 | |
dc.identifier.uri | http://hdl.handle.net/11446/2198 | |
dc.description | WOS: 000440751300024 | en_US |
dc.description | PubMed ID: 28471284 | en_US |
dc.description.abstract | Purpose: This study aims to evaluate the role of complement factor H (CFH) in response to intravitreal ranibizumab (IVR) treatment, which is administered to patients with neovascular age-related macular degeneration (nAMD).Methods: In this retrospective study, 90 nAMD patients' 90 eyes were evaluated. IVR was injected once a month for three consecutive months, and then, patients were followed up for five years by using pro re nata method.Results: Average visual acuity (BCVA) values in TT group for the third, fourth and fifth years were found to be significantly higher than those in TC and CC groups, while average BCVA values in TC group were significantly higher than those in CC group (all p = .000 < .0167).Conclusion: Patients with CFH TT genotype responded significantly better to treatment after third year, while patients with CC genotype had a poorer response to IVR. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TAYLOR & FRANCIS INC | en_US |
dc.identifier.doi | 10.1080/09273948.2017.1311925 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Age-related macular degeneration | en_US |
dc.subject | complement factor H polymorphism | en_US |
dc.subject | genetics | en_US |
dc.subject | inflammation | en_US |
dc.subject | intravitreal ranibizumab | en_US |
dc.title | Pharmacogenetic Aspect of Intravitreal Ranibizumab Treatment in Neovascular Age-Related Macular Degeneration: A Five-Year Follow-Up | en_US |
dc.type | article | en_US |
dc.relation.journal | OCULAR IMMUNOLOGY AND INFLAMMATION | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.volume | 26 | en_US |
dc.identifier.startpage | 971 | en_US |
dc.identifier.endpage | 977 | en_US |
dc.contributor.authorID | 0000-0003-2994-1077 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Sengul, Elvan Alper -- Rasier, Rifat -- Kockar, Alev -- Yuzbasioglu, Erdal] TC Istanbul Bilim Univ, Med Fac, Ophthalmol Dept, Istanbul, Turkey -- [Artunay, Ozgur] Haydarpasa Numune Training & Res Hosp, Ophthalmol Dept, Istanbul, Turkey -- [Afacan, Ceyda] Mimar Sinan Fine Arts Univ, Dept Stat, Istanbul, Turkey -- [Hancer, Veysel Sabri] Istinye Univ, Med Fac, Med Genet Dept, Istanbul, Turkey | en_US |