dc.contributor.author | Kahraman, S. | |
dc.contributor.author | Erdim, R. | |
dc.contributor.author | Helvacioglu, F. | |
dc.contributor.author | Dogan, A. | |
dc.contributor.author | Sozer, V | |
dc.contributor.author | Gunay, D. | |
dc.contributor.author | Aytekin, V | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T15:56:03Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T15:56:03Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0006-9248 | |
dc.identifier.issn | 1336-0345 | |
dc.identifier.uri | https://dx.doi.org/10.4149/BLL_2018_071 | |
dc.identifier.uri | http://hdl.handle.net/11446/2203 | |
dc.description | WOS: 000436626500011 | en_US |
dc.description | PubMed ID: 29947240 | en_US |
dc.description.abstract | OBJECTIVES: We aimed to associate a coronary artery disease (CAD) presence and severity with endothelial dysfunction (ED), carotid intima media thickness (CIMT) and Tissue Factor Pathway Inhibitor (TFPI). BACKGROUND: ED has a central role in atherosclerosis. CIMT and TFPI activity are also related with atherosclerosis and CAD. METHODS: In our prospective observational study, 50 patients had CAD and 30 had normal coronary arteries. Endothelial function was evaluated by endothelium-dependent flow-mediated dilatation (FMD) and nitroglycerinemediated dilatation (NMD) measurements. CIMT and Serum TFPI levels were also measured. RESULTS: TFPI was a statistically significant determinant between the two groups with an increased level in CAD (+) group (84.9 +/- 19.3 vs 70.2 +/- 14.7, p = 0.001). There was a positive correlation between CIMT and Gensini (r = 0.34, p = 0.014). There was a strong negative correlation between Gensini and FMD-NMD, statistically significant (FMD: r =-0.715, p < 0.001; NMD: r = -0.718, p < 0.001). CONCLUSION: We observed that ED, increased CIMT and TFPI levels were associated with CAD. Additionally, increased CIMT measurements and decreased FMD and NMD values had a positive correlation with GSS (Tab. 4, Fig. 6, Ref. 50). Text in PDF www.elis.sk. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | COMENIUS UNIV | en_US |
dc.identifier.doi | 10.4149/BLL_2018_071 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | coronary artery disease | en_US |
dc.subject | endothelial dysfunction | en_US |
dc.subject | tissue factor pathway inhibitor | en_US |
dc.title | The impact of TFPI on coronary atherosclerotic burden | en_US |
dc.type | article | en_US |
dc.relation.journal | BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.volume | 119 | en_US |
dc.identifier.startpage | 385 | en_US |
dc.identifier.endpage | 390 | en_US |
dc.contributor.authorID | 0000-0002-4996-8165 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Kahraman, S. -- Erdim, R. -- Helvacioglu, F. -- Dogan, A. -- Sozer, V -- Gunay, D. -- Aytekin, S. -- Aytekin, V] Istanbul Bilim Univ, Fac Med, Dept Cardiol, Istanbul, Turkey -- [Erdim, R. -- Aytekin, S. -- Aytekin, V] Sisli Florence Nightingale Hosp, Dept Cardiol, Istanbul, Turkey -- [Sozer, V] Yildiz Tech Univ, Dept Biochem, Istanbul, Turkey -- [Gunay, D.] Sisli Florence Nightingale Hosp, Dept Biochem, Istanbul, Turkey | en_US |