dc.contributor.author | Sahin, Deniz Goren | |
dc.contributor.author | Arat, Mutlu | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T15:56:06Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T15:56:06Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1473-0502 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.transci.2017.11.009 | |
dc.identifier.uri | http://hdl.handle.net/11446/2218 | |
dc.description | WOS: 000423246100008 | en_US |
dc.description.abstract | Background: Proper stem cell mobilization is one of the most important steps in hematopoietic stem cell transplantation (HSCT). The aim of this paper is to share our 6 years' experience and provide practical clinical approaches particularly for stem cell mobilization and collection within the series of more than 200 successive allogeneic HSCT at our transplant center. Subjects & Methods: Two hundred and seven consecutive patients who underwent allogeneic peripheral blood stem cell transplantation were included in this study. Age, sex, weight, complete blood counts, CD34(+) cell counts, total collected amount of CD34(+) cells, CD34(+) cells per 101 processed, mobilization failure and adverse events were reviewed. Results: Median age was 40.2 +/- 12.9 (21-68) years and 46.4 +/- 13.4 (17-67) years for donors and patients, respectively. The number of donors who had undergone adequate CD34(+) cell harvesting and completed the procedure on the fourth day was 67 (32.8% of all patients). Only 12 patients required cell apheresis both on day 5 and 6. Apheresis was completed on day 4 and/or day 5 in 94.2% of all our donors. There was no significant association between CD34(+) stem cell volume and age, gender and weight values of donors. Mobilization failure was not seen in our series. Conclusions: G-CSF is highly effective in 1/3 of the donors on the 4th day in order to collect enough number of stem cells. We propose that peripheral stem cell collection might start on day 4th of G-CSF treatment for avoiding G-CSF related side effects and complications. (C) 2017 Elsevier Ltd. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | en_US |
dc.identifier.doi | 10.1016/j.transci.2017.11.009 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Allogeneic stem cell transplantation | en_US |
dc.subject | Peripheral bood stem cell | en_US |
dc.subject | Stem cell mobilization | en_US |
dc.title | Peripheral blood stem cell collection for allogeneic hematopoietic stern cell transplantation: Practical implications after 200 consequent transplants | en_US |
dc.type | article | en_US |
dc.relation.journal | TRANSFUSION AND APHERESIS SCIENCE | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.volume | 56 | en_US |
dc.identifier.startpage | 800 | en_US |
dc.identifier.endpage | 803 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Sahin, Deniz Goren] Istanbul Bilim Univ, Sch Med, Dept Hematol, Istanbul, Turkey -- [Sahin, Deniz Goren -- Arat, Mutlu] Sisli Florence Nightingale Hosp, Stem Cell Transplantat Unit, Istanbul, Turkey | en_US |