dc.contributor.author | Poyraz, Muruvvet | |
dc.contributor.author | Matur, Zeliha | |
dc.contributor.author | Aysal, Fikret | |
dc.contributor.author | Tuzun, Erdem | |
dc.contributor.author | Hanoglu, Lutfu | |
dc.contributor.author | Oge, A. Emre | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T15:56:23Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T15:56:23Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1300-0667 | |
dc.identifier.issn | 1309-4866 | |
dc.identifier.uri | https://dx.doi.org/10.5152/npa.2016.14816 | |
dc.identifier.uri | http://hdl.handle.net/11446/2292 | |
dc.description | WOS: 000404296300015 | en_US |
dc.description | PubMed ID: 28680318 | en_US |
dc.description.abstract | Introduction: Cramp-fasciculation syndrome (CFS) is a rare peripheral nerve hyperexcitability syndrome. There are only a few reports on clinical and serological profile of a CFS cohort that was followed up by a single outpatient clinic. Methods: Clinical, electrophysiological, and serological features of 6 CFS patients (5 men, 1 woman; 27-65 years old) were investigated. Results: All patients presented with cramps, fasciculations, muscle pain, and autonomic symptoms, and 2 also reported numbness and burning sensation in limbs, suggestive of neuropathic pain. Antibodies to uncharacterized voltage-gated potassium channel (VGKC)-complex proteins were found in 2 patients and to contactin-associated protein-like 2 (CASPR2) in 1 patient. None of the patients had a tumor. Most of the patients revealed prolonged after-discharges following tibial nerve stimulation. Nerve conduction studies and R-R interval variability tests were normal, whereas sympathetic skin responses were increased in amplitude in 3 seronegative patients. Five patients showed favorable response to carbamazepine or pregabalin treatment, whereas 1 VGKC-antibody- positive patient was resistant to carbamazepine and immunosuppressant treatment. Conclusion: Neuropathic pain and VGKC-complex antibodies may be encountered in CFS patients. Although autonomic symptoms are commonly found in CFS, routine autonomic system tests which are done in electrophysiology laboratories might yield normal results. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | AVES | en_US |
dc.identifier.doi | 10.5152/npa.2016.14816 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Cramp-fasciculation syndrome (CFS) | en_US |
dc.subject | peripheral nerve hyperexcitability | en_US |
dc.subject | voltage-gated potassium channel (VGKC)-complex proteins | en_US |
dc.subject | neuropathic pain | en_US |
dc.title | Clinical, Electrophysiological, and Serological Evaluation of Patients with Cramp-Fasciculation Syndrome | en_US |
dc.type | article | en_US |
dc.relation.journal | NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.volume | 54 | en_US |
dc.identifier.startpage | 183 | en_US |
dc.identifier.endpage | 186 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Poyraz, Muruvvet -- Aysal, Fikret -- Hanoglu, Lutfu] Istanbul Medipol Univ, Sch Med, Dept Neurol, Istanbul, Turkey -- [Matur, Zeliha] Istanbul Bilim Univ, Sch Med, Dept Neurol, Istanbul, Turkey -- [Tuzun, Erdem -- Oge, A. Emre] Istanbul Univ, Istanbul Sch Med, Dept Neurol, Istanbul, Turkey | en_US |