dc.contributor.author | Akbal, Erdem | |
dc.contributor.author | Kocak, Erdem | |
dc.contributor.author | Koklu, Seyfettin | |
dc.contributor.author | Ergul, Bilal | |
dc.contributor.author | Akyurek, Omer | |
dc.contributor.author | Yilmaz, Fatma Meric | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T15:56:26Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T15:56:26Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0882-8245 | |
dc.identifier.issn | 1557-8976 | |
dc.identifier.uri | https://dx.doi.org/10.1089/vim.2016.0131 | |
dc.identifier.uri | http://hdl.handle.net/11446/2304 | |
dc.description | WOS: 000400644400006 | en_US |
dc.description | PubMed ID: 28414577 | en_US |
dc.description.abstract | Toll-like receptors (TLRs) may play an important role in hepatitis-B pathogenesis. However, serum TLR-2 and TLR-4 levels and their association with serum liver enzymes, hepatitis B virus (HBV) DNA, quantitative HBsAg levels, and liver biopsy findings, are unknown. A total of naive 40 HBeAg (-) chronic hepatitis B (CHB) patients and 20 healthy control subjects were recruited in this study. Liver tests, HBV DNA, serum TLR2 and TLR-4, and quantitative HBsAg levels were evaluated among all groups. The relationship among TLR-2, TLR-4, quantitative HBsAg levels and liver tests, and liver histological findings were investigated with correlation analysis. Serum TLR-2 and TLR-4 levels in HBeAg (-) CHB patients were higher than in the control group. There was a positive correlation between serum TLR-2, TLR-4, and HBV DNA and ALT levels. We have further demonstrated that serum TLR-2 levels are correlated with AST and quantitative HBsAg levels. However, TLRs levels were not linked to the liver biopsy findings. TLR can have an important role in hepatitis B pathogenesis. Liver injury in CHB may cause elevated TLR-2 and TLR-4 levels. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MARY ANN LIEBERT, INC | en_US |
dc.identifier.doi | 10.1089/vim.2016.0131 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | chronic hepatitis B | en_US |
dc.subject | TLR-2 | en_US |
dc.subject | TLR-4 | en_US |
dc.subject | quantitative HBsAg | en_US |
dc.title | Serum Toll-Like Receptor-2, Toll-Like Receptor-4 Levels in Patients with HBeAg-Negative Chronic Viral Hepatitis B | en_US |
dc.type | article | en_US |
dc.relation.journal | VIRAL IMMUNOLOGY | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.volume | 30 | en_US |
dc.identifier.startpage | 278 | en_US |
dc.identifier.endpage | 282 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Akbal, Erdem -- Kocak, Erdem] Istanbul Bilim Univ, Florence Nightingale Hosp, Dept Gastroenterol, Fac Med, TR-34387 Florence, Turkey -- [Koklu, Seyfettin] Hacettepe Univ, Dept Gastroenterol, Fac Med, Ankara, Turkey -- [Ergul, Bilal] Kirsehir State Hosp, Dept Gastroenterol, Kirsehir, Turkey -- [Akyurek, Omer] Medova Hosp, Dept Internal Med, Konya, Turkey -- [Yilmaz, Fatma Meric] Numune Educ & Res Hosp, Dept Med Biochem, Ankara, Turkey | en_US |