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dc.contributor.authorSolmaz, Volkan
dc.contributor.authorCinar, Bilge Piri
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorOzlece, Hatice Kose
dc.contributor.authorEroglu, Huseyin Avni
dc.contributor.authorTekatas, Aslan
dc.contributor.authorTaskiran, Dilek
dc.date.accessioned2019-08-13T12:10:23Z
dc.date.accessioned2019-08-13T15:56:26Z
dc.date.available2019-08-13T12:10:23Z
dc.date.available2019-08-13T15:56:26Z
dc.date.issued2017
dc.identifier.issn0753-3322
dc.identifier.issn1950-6007
dc.identifier.urihttps://dx.doi.org/10.1016/j.biopha.2017.02.027
dc.identifier.urihttp://hdl.handle.net/11446/2305
dc.descriptionWOS: 000402468200054en_US
dc.descriptionPubMed ID: 28249248en_US
dc.description.abstractThe purpose of the present study is to investigate the possible healing effects of octreotide (OCT) on motor performance, electrophysiological and histopathological findings of diabetic neuropathy in a rat model of diabetes mellitus (DM). To induce diabetes, rats were administered a single dose (60 mg/kg) of streptozotocin (STZ). Diabetic rats were treated either with saline (1 ml/kg/day, n = 7) or OCT (0.1 mg/kg/ day, n = 7) for four weeks. Seven rats served as control group and received no treatment. At the end of the study, electromyography (EMG), gross motor function (inclined plate test), general histology and the perineural thickness of sciatic nerve were evaluated. At the end of study, weight loss was significantly lower in OCT treated rats than that of saline treated ones (p < 0.001). Electrophysiologically, compound muscle action potential (CMAP) amplitudes of the saline treated DM group were significantly reduced than those of controls (p < 0.0001). Also, distal latency and CMAP durations were significantly prolonged in saline treated DM group (p < 0.05) compared to control. However, treatment of diabetic rats with OCT significantly counteracted these alterations in EMG. Furthermore, OCT significantly improved the motor performance scores in diabetic rats (p < 0.05). Histomorphometric assessment of the sciatic nerve demonstrated a significant reduction in perineural thickness in OCT treated group compared to saline group. In conclusion, OCT possesses beneficial effects against STZ-induced diabetic neuropathy, which promisingly support the use of OCT as a neuroprotective agent in patients with diabetic neuropathy. (C) 2017 Elsevier Masson SAS. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIERen_US
dc.identifier.doi10.1016/j.biopha.2017.02.027en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectDiabetic neuropathyen_US
dc.subjectOctreotideen_US
dc.subjectElectromyographyen_US
dc.titleNeuroprotective effects of octreotide on diabetic neuropathy in ratsen_US
dc.typearticleen_US
dc.relation.journalBIOMEDICINE & PHARMACOTHERAPYen_US
dc.departmentDBÜen_US
dc.identifier.volume89en_US
dc.identifier.startpage468en_US
dc.identifier.endpage472en_US
dc.contributor.authorID0000-0002-9045-2347en_US
dc.contributor.authorID0000-0002-4505-0939en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-temp[Solmaz, Volkan -- Ozlece, Hatice Kose -- Tekatas, Aslan] Trakya Univ, Fac Med, Dept Neurol, Edirne, Turkey -- [Cinar, Bilge Piri] Samsun Training & Reseach Hosp, Dept Neurol, Samsun, Turkey -- [Yigitturk, Gurkan] Ege Univ, Dept Histol & Embryol, Fac Med, Izmir, Turkey -- [Eroglu, Huseyin Avni] Kafkas Univ, Fac Med, Dept Physiol, Kars, Turkey -- [Erbas, Oytun] Istanbul Bilim Univ, Dept Physiol, Fac Med, Istanbul, Turkey -- [Taskiran, Dilek] Ege Univ, Fac Med, Dept Physiol, Izmir, Turkeyen_US


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