dc.contributor.author | Erkoc Kaya, Dudu | |
dc.contributor.author | Arikoglu, Hilal | |
dc.contributor.author | Kayis, Seyit Ali | |
dc.contributor.author | Ozturk, Onur | |
dc.contributor.author | Gonen, Mustafa Sait | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T15:56:44Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T15:56:44Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1300-0144 | |
dc.identifier.issn | 1303-6165 | |
dc.identifier.uri | https://dx.doi.org/10.3906/sag-1507-160 | |
dc.identifier.uri | http://hdl.handle.net/11446/2372 | |
dc.description | WOS: 000395632600003 | en_US |
dc.description | PubMed ID: 28263491 | en_US |
dc.description.abstract | Background/aim: Type 2 diabetes (T2D) is a multifactorial disease, determined by environmental and genetic factors. Currently, the transcription factor 7-like 2 (TCF7L2) gene shows the strongest association with T2D. In this study, we investigated whether TCF7L2 gene polymorphisms are associated with T2D in a Turkish population. Materials and methods: Using PCR-RFLP and PCR-SSCP, we genotyped six intronic polymorphisms in the TCF7L2 gene, commonly associated with T2D, in 169 individuals with diabetes and 119 healthy controls. Results: We found that rs7903146 C -> T substitution in intron 3 (OR: 1.9, P = 0.005) and rs12255372 G -> T substitution in intron 4 (OR: 2.1, P = 0.002) were significantly associated with T2D while other SNPs were not associated (P > 0.05). We determined no association between TCF7L2 gene polymorphisms and fasting glucose, fasting insulin, HbA1c, or HOMA-IR levels (P > 0.05), except for rs7903146 C -> T substitution, which was significantly associated with the fasting glucose level (P = 0.003). Conclusion: Our results indicate that, in the Turkish population, the T allele of the rs7903146 (C -> T) and rs12255372 (G -> T) polymorphisms in the TCF7L2 gene is an independent risk factor for the development of T2D. | en_US |
dc.description.sponsorship | Selcuk University Research Foundation [09202048] | en_US |
dc.description.sponsorship | We would like to thank Dr Hulya Ozdemir and Dr Suleyman Hilmi Ipekci for their assistance in this study. This study was supported by the Selcuk University Research Foundation (09202048). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY | en_US |
dc.identifier.doi | 10.3906/sag-1507-160 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Single nucleotide polymorphism | en_US |
dc.subject | TCF7L2 gene | en_US |
dc.subject | type 2 diabetes mellitus | en_US |
dc.subject | Wnt pathway | en_US |
dc.title | Transcription factor 7-like 2 (TCF7L2) gene polymorphisms are strong predictors of type 2 diabetes among nonobese diabetics in the Turkish population | en_US |
dc.type | article | en_US |
dc.relation.journal | TURKISH JOURNAL OF MEDICAL SCIENCES | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.volume | 47 | en_US |
dc.identifier.startpage | 22 | en_US |
dc.identifier.endpage | 28 | en_US |
dc.contributor.authorID | 0000-0003-3404-4135 | en_US |
dc.contributor.authorID | 0000-0002-1089-623X | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Erkoc Kaya, Dudu -- Arikoglu, Hilal] Selcuk Univ, Dept Med Biol, Fac Med, Konya, Turkey -- [Kayis, Seyit Ali] Karabuk Univ, Dept Med Informat & Biostat, Karabuk, Turkey -- [Ozturk, Onur] Inonu Univ, Dept Biophys, Fac Med, Malatya, Turkey -- [Gonen, Mustafa Sait] Istanbul Bilim Univ, Dept Endocrinol & Metab Dis, Fac Med, Istanbul, Turkey | en_US |