dc.contributor.author | Sengul, Elvan Alper | |
dc.contributor.author | Artunay, Ozgur | |
dc.contributor.author | Kumral, Esra Turkseven | |
dc.contributor.author | Yenerel, Melda | |
dc.contributor.author | Rasier, Rifat | |
dc.contributor.author | Kockar, Alev | |
dc.contributor.author | Yuzbasioglu, Erdal | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T15:56:49Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T15:56:49Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1080-7683 | |
dc.identifier.issn | 1557-7732 | |
dc.identifier.uri | https://dx.doi.org/10.1089/jop.2016.0014 | |
dc.identifier.uri | http://hdl.handle.net/11446/2392 | |
dc.description | WOS: 000390408000006 | en_US |
dc.description | PubMed ID: 27860530 | en_US |
dc.description.abstract | Purpose: The objective of this study was to investigate the effect of multiple intravitreal ranibizumab (IVR) injections on the retinal nerve fiber layer (RNFL) in neovascular age-related macular degeneration (nAMD). Methods: One hundred sixty-eight eyes of 168 patients with nAMD who received an IVR at least 3 times were included in this prospective interventional case series. The RNFL thickness data on 80 healthy eyes, used as the control group, were obtained. The patients were grouped as follows: 3-10 injections (group 1, 62 eyes, 37%), 10-20 injections (group 2, 62 eyes, 37%), and 20 injections (group 3, 44 eyes, 26%). The RNFL thickness was measured by spectral domain optical coherence tomography. Results: The mean baseline measurement of the RNFL thickness was 97.46.4m in the control group, 96.4 +/- 5.6m in group 1, 93.8 +/- 4.6m in group 2, and 93.2 +/- 5.3m in group 3. At the last follow-up, it was 95.1 +/- 2.4m in the control group, 93.4 +/- 7.3m in group 1, 90.5 +/- 3.6m in group 2, and 89.2 +/- 4.9m in group 3 (all P values >0.050). A statistically significant difference was not found between the mean total RNFL thickness of the eyes that received injections and that of the eyes in the healthy control group (P value >0.050). A statistically significant difference was not found in all the treatment groups between the intraocular pressure level taken 1 day after the administration of the injections and that recorded preintervention (all P values >0.050). Conclusion: Repeated IVR did not lead to a significant change in RNFL thickness in patients with nAMD. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MARY ANN LIEBERT, INC | en_US |
dc.identifier.doi | 10.1089/jop.2016.0014 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | age-related macular degeneration | en_US |
dc.subject | intravitreal ranibizumab | en_US |
dc.subject | retinal nerve fiber layer | en_US |
dc.title | Retinal Nerve Fiber Layer Thickness Changes in Age-Related Macular Degeneration Treated with Multiple Intravitreal Ranibizumab | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.volume | 32 | en_US |
dc.identifier.startpage | 665 | en_US |
dc.identifier.endpage | 670 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Sengul, Elvan Alper -- Rasier, Rifat -- Kockar, Alev -- Yuzbasioglu, Erdal] TC Istanbul Bilim Univ, Fac Med, Dept Ophthalmol, Istanbul, Turkey -- [Artunay, Ozgur] Istanbul Med Hosp, Dept Ophthalmol, Istanbul, Turkey -- [Kumral, Esra Turkseven -- Yenerel, Melda] Haydarpasa Numune Training & Res Hosp, Dept Ophthalmol, Istanbul, Turkey | en_US |