dc.contributor.author | Findikli, Ebru | |
dc.contributor.author | Camkurt, Mehmet Akif | |
dc.contributor.author | Karaaslan, Mehmet Fatih | |
dc.contributor.author | Kurutas, Ergul Belge | |
dc.contributor.author | Altun, Hatice | |
dc.contributor.author | Izci, Filiz | |
dc.contributor.author | Kardas, Selcuk | |
dc.date.accessioned | 2019-08-13T12:10:23Z | |
dc.date.accessioned | 2019-08-13T15:56:54Z | |
dc.date.available | 2019-08-13T12:10:23Z | |
dc.date.available | 2019-08-13T15:56:54Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0165-1781 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.psychres.2016.04.098 | |
dc.identifier.uri | http://hdl.handle.net/11446/2410 | |
dc.description | WOS: 000384776700048 | en_US |
dc.description | PubMed ID: 27512921 | en_US |
dc.description.abstract | Sex hormones, particularly estrogen, are suggested to play a role in the physiopathology of generalized anxiety disorder (GAD). Estrogen functions through the estrogen receptors alpha and beta and the recently discovered G protein-coupled estrogen receptor 1 (GPER1). This study aimed, for the first time, to evaluate serum GPER1 levels in drug-naive patients with GAD. This study included 40 newly diagnosed drug -naive patients with GAD aged between 18 and 50 years and 40 age- and gender-matched healthy controls. Medical histories were obtained, and physical examinations and laboratory tests were conducted; the Hamilton Anxiety Rating Scale (HAM-A) was also used for all participants. Serum GPER1 levels were measured. The serum GPER1 level was significantly higher in the patients with GAD than in the controls. A positive significant correlation was observed between the GPER1 level and the HAM-A score. The receiver operating characteristic analysis revealed a sensitivity, specificity, positive predictive value, and negative predictive value of 85.0%, 82.5%, 82.9%, and 84.6%, respectively, for the presence of anxiety when the serum GPER1 value was >= 0.14 (the area under the curve was 0.904.). In conclusion, this study demonstrated that GPER1 levels were associated with the anxiety levels of patients, and that the serum GPER1 level was a valuable predictor of the presence of anxiety independent of gender. (C) 2016 Elsevier Ireland Ltd. All rights reserved. | en_US |
dc.description.sponsorship | Kahramanmaras Sutcuimam University [2014/3-46 M] | en_US |
dc.description.sponsorship | This study was supported financially by the Kahramanmaras Sutcuimam University Scientific research project unit (Project no. 2014/3-46 M). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ELSEVIER IRELAND LTD | en_US |
dc.identifier.doi | 10.1016/j.psychres.2016.04.098 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Estrogen | en_US |
dc.subject | Receptor | en_US |
dc.subject | GPER1 | en_US |
dc.subject | Sex hormones | en_US |
dc.subject | Anxiety | en_US |
dc.title | Serum levels of G protein-coupled estrogen receptor 1 (GPER1) in drug-naive patients with generalized anxiety disorder | en_US |
dc.type | article | en_US |
dc.relation.journal | PSYCHIATRY RESEARCH | en_US |
dc.department | DBÜ | en_US |
dc.identifier.volume | 244 | en_US |
dc.identifier.startpage | 312 | en_US |
dc.identifier.endpage | 316 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Findikli, Ebru -- Karaaslan, Mehmet Fatih -- Kardas, Selcuk] Kahramanmaras Sutcu Imam Univ, Dept Psychiat, Kahramanmaras, Turkey -- [Camkurt, Mehmet Akif] Afsin State Hosp, Dept Psychiat, Kahramanmaras, Turkey -- [Kurutas, Ergul Belge] Kahramanmaras Sutcu Imam Univ, Dept Biochem, Kahramanmaras, Turkey -- [Altun, Hatice] Kahramanmaras Sutcu Imam Univ, Dept Child & Adolescent Psychiat, Kahramanmaras, Turkey -- [Izci, Filiz] Bilim Univ, Dept Psychiat, Istanbul, Turkey -- [Findikli, Huseyin Avni] Adiyaman Univ, Dept Internal Med, Adiyaman, Turkey | en_US |